A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2)

L. T. Roten, M. H. Fenstad, S. Forsmo, M. P. Johnson, E. K. Moses, R. Austgulen, F. Skorpen

Research output: Contribution to journalArticlepeer-review

37 Scopus citations

Abstract

The etiology of preeclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Although many candidate genes for preeclampsia have been suggested and studied, the specific causative genes still remain to be identified. Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine and estrogen degradation and has recently been ascribed a role in development of preeclampsia. In the present study, we have examined the COMT gene by genotyping the functional Val108/158Met polymorphism (rs4680) and an additional single-nucleotide polymorphism, rs6269, predicting COMT activity haplotypes in a large Norwegian case/control cohort (ncases = 1135, ncontrols= 2262). A low COMT activity haplotype is associated with recurrent preeclampsia in our cohort. This may support the role of redox-regulated signaling and oxidative stress in preeclampsia pathogenesis as suggested by recent studies in a genetic mouse model. The COMT gene might be a genetic risk factor shared between preeclampsia and cardiovascular diseases.

Original languageEnglish (US)
Article numbergar014
Pages (from-to)439-446
Number of pages8
JournalMolecular Human Reproduction
Volume17
Issue number7
DOIs
StatePublished - Jul 2011
Externally publishedYes

Keywords

  • 158Met
  • COMT
  • Catechol-O-methyltransferase
  • Haplotypes
  • Preeclampsia
  • Val108

ASJC Scopus subject areas

  • Reproductive Medicine
  • Embryology
  • Molecular Biology
  • Genetics
  • Obstetrics and Gynecology
  • Developmental Biology
  • Cell Biology

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