A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2)

L. T. Roten; M. H. Fenstad; S. Forsmo; M. P. Johnson; E. K. Moses; R. Austgulen; F. Skorpen

doi:10.1093/molehr/gar014

A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2)

L. T. Roten, M. H. Fenstad, S. Forsmo, M. P. Johnson, E. K. Moses, R. Austgulen, F. Skorpen

Research output: Contribution to journal › Article › peer-review

36 Scopus citations

Abstract

The etiology of preeclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Although many candidate genes for preeclampsia have been suggested and studied, the specific causative genes still remain to be identified. Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine and estrogen degradation and has recently been ascribed a role in development of preeclampsia. In the present study, we have examined the COMT gene by genotyping the functional Val108/158Met polymorphism (rs4680) and an additional single-nucleotide polymorphism, rs6269, predicting COMT activity haplotypes in a large Norwegian case/control cohort (n_cases = 1135, n_controls= 2262). A low COMT activity haplotype is associated with recurrent preeclampsia in our cohort. This may support the role of redox-regulated signaling and oxidative stress in preeclampsia pathogenesis as suggested by recent studies in a genetic mouse model. The COMT gene might be a genetic risk factor shared between preeclampsia and cardiovascular diseases.

Original language	English (US)
Article number	gar014
Pages (from-to)	439-446
Number of pages	8
Journal	Molecular Human Reproduction
Volume	17
Issue number	7
DOIs	https://doi.org/10.1093/molehr/gar014
State	Published - Jul 1 2011

Keywords

158Met
COMT
Catechol-O-methyltransferase
Haplotypes
Preeclampsia
Val108

ASJC Scopus subject areas

Reproductive Medicine
Embryology
Molecular Biology
Genetics
Obstetrics and Gynecology
Developmental Biology
Cell Biology

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title = "A low COMT activity haplotype is associated with recurrent preeclampsia in a Norwegian population cohort (HUNT2)",

abstract = "The etiology of preeclampsia is complex, with susceptibility being attributable to multiple environmental factors and a large genetic component. Although many candidate genes for preeclampsia have been suggested and studied, the specific causative genes still remain to be identified. Catechol-O-methyltransferase (COMT) is an enzyme involved in catecholamine and estrogen degradation and has recently been ascribed a role in development of preeclampsia. In the present study, we have examined the COMT gene by genotyping the functional Val108/158Met polymorphism (rs4680) and an additional single-nucleotide polymorphism, rs6269, predicting COMT activity haplotypes in a large Norwegian case/control cohort (ncases = 1135, ncontrols= 2262). A low COMT activity haplotype is associated with recurrent preeclampsia in our cohort. This may support the role of redox-regulated signaling and oxidative stress in preeclampsia pathogenesis as suggested by recent studies in a genetic mouse model. The COMT gene might be a genetic risk factor shared between preeclampsia and cardiovascular diseases.",

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AU - Johnson, M. P.

AU - Moses, E. K.

AU - Austgulen, R.

AU - Skorpen, F.

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