A locus on chromosome 10 influences C-reactive protein levels in two independent populations

Ulrich Broeckel, Christian Hengstenberg, Bjoern Mayer, Karen Maresso, Daniel Gaudet, Ondrej Seda, Johanne Tremblay, Stephan Holmer, Jeanette Erdmann, Christian Glöckner, Michael Harrison, Lisa J. Martin, Jeff T. Williams, Gerd Schmitz, Guenter A.J. Riegger, Howard J. Jacob, Pavel Hamet, Heribert Schunkert

    Research output: Contribution to journalArticlepeer-review

    8 Scopus citations

    Abstract

    High sensitivity C-reactive protein (hsCRP) is an independent risk factor for cardiovascular disease, such as stroke or coronary artery disease. Genetic factors influence significantly the inter-individual variability of hsCRP. The aim of this study was to identify genomic regions influencing hsCRP levels. A genome scan was performed in two independent studies of Caucasian populations, namely 513 Western-European families ascertained for myocardial infarction (n = 1,406) and 120 French-Canadian families diagnosed with hypertension (n = 758). In the myocardial infarction families, 31% of the inter-individual variation of hsCRP levels was explained by genetic factors (P = 0.0000015) and loci influencing hsCRP were identified on chromosomes 10 (at 141 cM) and 5 (at 150 cM) with multipoint LOD scores of 3.15 and 2.23, respectively. An additional suggestive signal was detected on chromosome 2 in subset analyses. A similar degree of heritability has been observed in a second independent population of French-Canadian hypertensive families for hsCRP (30%) and linkage results for chromosome 10 were confirmed with maximum LOD score of 2.7. We identified a chromosomal region in two independent populations which influences hsCRP in addition to several unique regions. This provides targets for the identification of genes involved in the regulation of hsCRP and the development and progression of vascular disease, including stroke.

    Original languageEnglish (US)
    Pages (from-to)95-102
    Number of pages8
    JournalHuman Genetics
    Volume122
    Issue number1
    DOIs
    StatePublished - Aug 2007

    ASJC Scopus subject areas

    • Genetics
    • Genetics(clinical)

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