A limited role for antibody in protective immunity induced by rCPAF and CpG vaccination against primary genital Chlamydia muridarum challenge

Ashlesh K. Murthy, Bharat K.R. Chaganty, Weidang Li, M. Neal Guentzel, James P. Chambers, J. Seshu, Guangming Zhong, Bernard P. Arulanandam

Research output: Contribution to journalArticle

20 Scopus citations

Abstract

Mice deficient in B cells (μmT mice) were used to evaluate the role of antibody in enhanced chlamydial clearance and reduction of pathology afforded by vaccination with recombinant chlamydial protease-like activity factor (rCPAF). Enhanced, but comparable, chlamydial clearance was observed in μmT and wild-type (WT) mice after rCPAF+CpG vaccination. Chlamydia-induced pathology was present in mock-immunized animals, but at significantly greater levels in μmT than WT mice, whereas vaccinated μmT and WT mice exhibited similar reductions in pathology. Thus, antibodies may play a role in protection against chlamydial pathology after primary infection, but were largely dispensable in rCPAF+CpG-induced chlamydial clearance and reduction in pathology.

Original languageEnglish (US)
Pages (from-to)271-279
Number of pages9
JournalFEMS Immunology and Medical Microbiology
Volume55
Issue number2
DOIs
StatePublished - Mar 2009

ASJC Scopus subject areas

  • Immunology and Allergy
  • Microbiology
  • Immunology
  • Microbiology (medical)
  • Infectious Diseases

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