A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex

Peter Kochunov, William E Rogers, Jean Francois Mangin, Jack L Lancaster

Research output: Contribution to journalArticle

29 Citations (Scopus)

Abstract

Sharing of analysis techniques and tools is among the main driving forces of modern neuroscience. We describe a library of tools developed to quantify global and regional differences in cortical anatomy in high resolution structural MR images. This library is distributed as a plug-in application for popular structural analysis software, BrainVisa (BV). It contains tools to measure global and regional gyrification, gray matter thickness and sulcal and gyral white matter spans. We provide a description of each tool and examples for several case studies to demonstrate their use. These examples show how the BV library was used to study cortical folding process during antenatal development and recapitulation of this process during cerebral aging. Further, the BV library was used to perform translation research in humans and nonhuman primates on the genetics of cerebral gyrification. This library, including source code and self-contained binaries for popular computer platforms, is available from the NIH-Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) resource (http://www.nitrc.org/ projects/brainvisa-ext).

Original languageEnglish (US)
Pages (from-to)81-96
Number of pages16
JournalNeuroinformatics
Volume10
Issue number1
DOIs
StatePublished - Jan 2012
Externally publishedYes

Fingerprint

Cerebral Cortex
Libraries
Aging of materials
Neuroimaging
Informatics
Neurosciences
Structural analysis
Primates
Anatomy
Software
Genetics
Research

Keywords

  • BrainVisa
  • Cortical analysis tools
  • Gray matter thickness
  • Object based morphometry
  • Sulcal span

ASJC Scopus subject areas

  • Neuroscience(all)
  • Information Systems
  • Software

Cite this

A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex. / Kochunov, Peter; Rogers, William E; Mangin, Jean Francois; Lancaster, Jack L.

In: Neuroinformatics, Vol. 10, No. 1, 01.2012, p. 81-96.

Research output: Contribution to journalArticle

Kochunov, Peter ; Rogers, William E ; Mangin, Jean Francois ; Lancaster, Jack L. / A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex. In: Neuroinformatics. 2012 ; Vol. 10, No. 1. pp. 81-96.
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