A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex

Peter Kochunov; William Rogers; Jean Francois Mangin; Jack Lancaster

doi:10.1007/s12021-011-9127-9

A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex

Peter Kochunov, William Rogers, Jean Francois Mangin, Jack Lancaster

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

Sharing of analysis techniques and tools is among the main driving forces of modern neuroscience. We describe a library of tools developed to quantify global and regional differences in cortical anatomy in high resolution structural MR images. This library is distributed as a plug-in application for popular structural analysis software, BrainVisa (BV). It contains tools to measure global and regional gyrification, gray matter thickness and sulcal and gyral white matter spans. We provide a description of each tool and examples for several case studies to demonstrate their use. These examples show how the BV library was used to study cortical folding process during antenatal development and recapitulation of this process during cerebral aging. Further, the BV library was used to perform translation research in humans and nonhuman primates on the genetics of cerebral gyrification. This library, including source code and self-contained binaries for popular computer platforms, is available from the NIH-Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) resource (http://www.nitrc.org/ projects/brainvisa-ext).

Original language	English (US)
Pages (from-to)	81-96
Number of pages	16
Journal	Neuroinformatics
Volume	10
Issue number	1
DOIs	https://doi.org/10.1007/s12021-011-9127-9
State	Published - Jan 2012
Externally published	Yes

Keywords

BrainVisa
Cortical analysis tools
Gray matter thickness
Object based morphometry
Sulcal span

ASJC Scopus subject areas

Software
Neuroscience(all)
Information Systems

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10.1007/s12021-011-9127-9

Cite this

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title = "A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex",

abstract = "Sharing of analysis techniques and tools is among the main driving forces of modern neuroscience. We describe a library of tools developed to quantify global and regional differences in cortical anatomy in high resolution structural MR images. This library is distributed as a plug-in application for popular structural analysis software, BrainVisa (BV). It contains tools to measure global and regional gyrification, gray matter thickness and sulcal and gyral white matter spans. We provide a description of each tool and examples for several case studies to demonstrate their use. These examples show how the BV library was used to study cortical folding process during antenatal development and recapitulation of this process during cerebral aging. Further, the BV library was used to perform translation research in humans and nonhuman primates on the genetics of cerebral gyrification. This library, including source code and self-contained binaries for popular computer platforms, is available from the NIH-Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) resource (http://www.nitrc.org/ projects/brainvisa-ext).",

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author = "Peter Kochunov and William Rogers and Mangin, {Jean Francois} and Jack Lancaster",

note = "Funding Information: Acknowledgment This research was supported by the National Institute of Biomedical Imaging and Bioengineering (K01 EB006395) grant to P.K.",

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doi = "10.1007/s12021-011-9127-9",

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AU - Lancaster, Jack

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AB - Sharing of analysis techniques and tools is among the main driving forces of modern neuroscience. We describe a library of tools developed to quantify global and regional differences in cortical anatomy in high resolution structural MR images. This library is distributed as a plug-in application for popular structural analysis software, BrainVisa (BV). It contains tools to measure global and regional gyrification, gray matter thickness and sulcal and gyral white matter spans. We provide a description of each tool and examples for several case studies to demonstrate their use. These examples show how the BV library was used to study cortical folding process during antenatal development and recapitulation of this process during cerebral aging. Further, the BV library was used to perform translation research in humans and nonhuman primates on the genetics of cerebral gyrification. This library, including source code and self-contained binaries for popular computer platforms, is available from the NIH-Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) resource (http://www.nitrc.org/ projects/brainvisa-ext).

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A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex

Abstract

Keywords

ASJC Scopus subject areas

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