Abstract
Sharing of analysis techniques and tools is among the main driving forces of modern neuroscience. We describe a library of tools developed to quantify global and regional differences in cortical anatomy in high resolution structural MR images. This library is distributed as a plug-in application for popular structural analysis software, BrainVisa (BV). It contains tools to measure global and regional gyrification, gray matter thickness and sulcal and gyral white matter spans. We provide a description of each tool and examples for several case studies to demonstrate their use. These examples show how the BV library was used to study cortical folding process during antenatal development and recapitulation of this process during cerebral aging. Further, the BV library was used to perform translation research in humans and nonhuman primates on the genetics of cerebral gyrification. This library, including source code and self-contained binaries for popular computer platforms, is available from the NIH-Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) resource (http://www.nitrc.org/ projects/brainvisa-ext).
| Original language | English (US) |
|---|---|
| Pages (from-to) | 81-96 |
| Number of pages | 16 |
| Journal | Neuroinformatics |
| Volume | 10 |
| Issue number | 1 |
| DOIs | |
| State | Published - Jan 2012 |
| Externally published | Yes |
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Keywords
- BrainVisa
- Cortical analysis tools
- Gray matter thickness
- Object based morphometry
- Sulcal span
ASJC Scopus subject areas
- Neuroscience(all)
- Information Systems
- Software
Cite this
A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex. / Kochunov, Peter; Rogers, William E; Mangin, Jean Francois; Lancaster, Jack L.
In: Neuroinformatics, Vol. 10, No. 1, 01.2012, p. 81-96.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A library of cortical morphology analysis tools to study development, aging and genetics of cerebral cortex
AU - Kochunov, Peter
AU - Rogers, William E
AU - Mangin, Jean Francois
AU - Lancaster, Jack L
PY - 2012/1
Y1 - 2012/1
N2 - Sharing of analysis techniques and tools is among the main driving forces of modern neuroscience. We describe a library of tools developed to quantify global and regional differences in cortical anatomy in high resolution structural MR images. This library is distributed as a plug-in application for popular structural analysis software, BrainVisa (BV). It contains tools to measure global and regional gyrification, gray matter thickness and sulcal and gyral white matter spans. We provide a description of each tool and examples for several case studies to demonstrate their use. These examples show how the BV library was used to study cortical folding process during antenatal development and recapitulation of this process during cerebral aging. Further, the BV library was used to perform translation research in humans and nonhuman primates on the genetics of cerebral gyrification. This library, including source code and self-contained binaries for popular computer platforms, is available from the NIH-Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) resource (http://www.nitrc.org/ projects/brainvisa-ext).
AB - Sharing of analysis techniques and tools is among the main driving forces of modern neuroscience. We describe a library of tools developed to quantify global and regional differences in cortical anatomy in high resolution structural MR images. This library is distributed as a plug-in application for popular structural analysis software, BrainVisa (BV). It contains tools to measure global and regional gyrification, gray matter thickness and sulcal and gyral white matter spans. We provide a description of each tool and examples for several case studies to demonstrate their use. These examples show how the BV library was used to study cortical folding process during antenatal development and recapitulation of this process during cerebral aging. Further, the BV library was used to perform translation research in humans and nonhuman primates on the genetics of cerebral gyrification. This library, including source code and self-contained binaries for popular computer platforms, is available from the NIH-Neuroimaging Informatics Tools and Resources Clearinghouse (NITRC) resource (http://www.nitrc.org/ projects/brainvisa-ext).
KW - BrainVisa
KW - Cortical analysis tools
KW - Gray matter thickness
KW - Object based morphometry
KW - Sulcal span
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UR - http://www.scopus.com/inward/citedby.url?scp=84859383386&partnerID=8YFLogxK
U2 - 10.1007/s12021-011-9127-9
DO - 10.1007/s12021-011-9127-9
M3 - Article
C2 - 21698393
AN - SCOPUS:84859383386
VL - 10
SP - 81
EP - 96
JO - Neuroinformatics
JF - Neuroinformatics
SN - 1539-2791
IS - 1
ER -