A lateral ridge augmentation study to evaluate a synthetic membrane for guided bone regeneration: an experiment in the canine mandible

Matthew Vierra, Lian Ping Mau, Guy Huynh-ba, John Schoolfield, David L Cochran

Research output: Contribution to journalArticle

5 Scopus citations


OBJECTIVES: To evaluate guided bone regeneration outcomes in defects protected with an in situ formed polyethylene glycol (PEG) hydrogel membrane as compared to a non-cross-linked collagen membrane (CM).

MATERIAL AND METHODS: Four mandibular alveolar ridge defects were created in eight hound dogs. Regenerative procedures were randomly allocated to one of four groups consisting of freeze-dried bone allograft, which is referred to in this study as freeze-dried bone xenograft (FDBX) + PEG, autogenous bone (AB) + PEG, AB + CM, and AB alone. After 8 weeks, titanium dental implants were placed into augmented sites. After 8 weeks of allowed time for osseointegration, the animals were sacrificed to harvest block specimens for bone-to-implant contact (BIC) and ridge width histomorphometric analysis.

RESULTS: Polyethylene glycol membranes had an exposure rate of 50% as compared to 12.5% for sites grafted with CM. Regenerative outcomes with respect to implant placement were least favorable for FDBX + PEG which had implants placed in 37.5% of augmented sites compared to 100% implant placement for all other groups. No statistically significant differences were noted between groups for ridge width measurements in implant and non-implant histologic sections (P > 0.05). Buccal BIC (%) values between treatment groups also failed to reach statistical significant difference (FDBX + PEG [60.2 ± 9.4]; AB + PEG [58.8 ± 8.5]; AB + CM [57.9 ± 12.8]; AB [61.0 ± 10.2]).

CONCLUSION: When used in conjunction with FDBX, PEG had unpredictable bone formation and in most cases negatively impacted future implant placement.

Original languageEnglish (US)
Pages (from-to)73-82
Number of pages10
JournalClinical Oral Implants Research
Issue number1
StatePublished - Jan 1 2016



  • animal study
  • barrier membrane
  • defect
  • dental implants
  • guided bone regeneration

ASJC Scopus subject areas

  • Oral Surgery

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