Conventional cardiopulmonary bypass (CPB) is associated with progressive anasarca and hypoxic acidosis. The former is reduced by hetastarch, mannitol, furosemide, albumin and blood. Thirty six large nubian cross ungulates were subjected to CPB to test their capacity to act as oxygen yielding blood substitutes capable of reducing anasarca. A hyperosmolar oxygen-yielding blood substitute is feasible for CPB to enhance brain oxygenation and diminish anasarca. It decreases anasarca more than normo-osmolar crystalloid prime combined with hetastarch, mannitol, and furosemide. A large portion of the perfluorocarbon can be retrieved post-operatively.
|Original language||English (US)|
|Journal||Artificial Cells, Blood Substitutes, and Immobilization Biotechnology|
|State||Published - Nov 1 1994|
|Event||Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA|
Duration: Jul 24 1994 → Jul 27 1994
ASJC Scopus subject areas
- Biomedical Engineering