A hyperosmolar oxygen yielding blood substitute for cardiopulmonary bypass

T. M. Runge; J. W. McGinity; S. E. Frisbee; Y. M. Laurel; J. H. Calhoon; J. R. Ybarra; S. E. Ottmers; J. C. Briceno

A hyperosmolar oxygen yielding blood substitute for cardiopulmonary bypass

T. M. Runge, J. W. McGinity, S. E. Frisbee, Y. M. Laurel, J. H. Calhoon, J. R. Ybarra, S. E. Ottmers, J. C. Briceno

Department of Cardiothoracic Surgery

Research output: Contribution to journal › Conference article › peer-review

4 Scopus citations

Abstract

Conventional cardiopulmonary bypass (CPB) is associated with progressive anasarca and hypoxic acidosis. The former is reduced by hetastarch, mannitol, furosemide, albumin and blood. Thirty six large nubian cross ungulates were subjected to CPB to test their capacity to act as oxygen yielding blood substitutes capable of reducing anasarca. A hyperosmolar oxygen-yielding blood substitute is feasible for CPB to enhance brain oxygenation and diminish anasarca. It decreases anasarca more than normo-osmolar crystalloid prime combined with hetastarch, mannitol, and furosemide. A large portion of the perfluorocarbon can be retrieved post-operatively.

Original language	English (US)
Pages (from-to)	A154
Journal	Artificial Cells, Blood Substitutes, and Immobilization Biotechnology
Volume	22
Issue number	5
State	Published - Nov 1994
Event	Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) - Boston, MA, USA Duration: Jul 24 1994 → Jul 27 1994

ASJC Scopus subject areas

Biotechnology
Biomedical Engineering

Cite this

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title = "A hyperosmolar oxygen yielding blood substitute for cardiopulmonary bypass",

abstract = "Conventional cardiopulmonary bypass (CPB) is associated with progressive anasarca and hypoxic acidosis. The former is reduced by hetastarch, mannitol, furosemide, albumin and blood. Thirty six large nubian cross ungulates were subjected to CPB to test their capacity to act as oxygen yielding blood substitutes capable of reducing anasarca. A hyperosmolar oxygen-yielding blood substitute is feasible for CPB to enhance brain oxygenation and diminish anasarca. It decreases anasarca more than normo-osmolar crystalloid prime combined with hetastarch, mannitol, and furosemide. A large portion of the perfluorocarbon can be retrieved post-operatively.",

author = "Runge, {T. M.} and McGinity, {J. W.} and Frisbee, {S. E.} and Laurel, {Y. M.} and Calhoon, {J. H.} and Ybarra, {J. R.} and Ottmers, {S. E.} and Briceno, {J. C.}",

year = "1994",

month = nov,

language = "English (US)",

volume = "22",

pages = "A154",

journal = "Artificial Cells, Blood Substitutes, and Immobilization Biotechnology",

issn = "1073-1199",

publisher = "Informa Healthcare",

number = "5",

note = "Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI) ; Conference date: 24-07-1994 Through 27-07-1994",

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TY - JOUR

T1 - A hyperosmolar oxygen yielding blood substitute for cardiopulmonary bypass

AU - Runge, T. M.

AU - McGinity, J. W.

AU - Frisbee, S. E.

AU - Laurel, Y. M.

AU - Calhoon, J. H.

AU - Ybarra, J. R.

AU - Ottmers, S. E.

AU - Briceno, J. C.

PY - 1994/11

Y1 - 1994/11

N2 - Conventional cardiopulmonary bypass (CPB) is associated with progressive anasarca and hypoxic acidosis. The former is reduced by hetastarch, mannitol, furosemide, albumin and blood. Thirty six large nubian cross ungulates were subjected to CPB to test their capacity to act as oxygen yielding blood substitutes capable of reducing anasarca. A hyperosmolar oxygen-yielding blood substitute is feasible for CPB to enhance brain oxygenation and diminish anasarca. It decreases anasarca more than normo-osmolar crystalloid prime combined with hetastarch, mannitol, and furosemide. A large portion of the perfluorocarbon can be retrieved post-operatively.

AB - Conventional cardiopulmonary bypass (CPB) is associated with progressive anasarca and hypoxic acidosis. The former is reduced by hetastarch, mannitol, furosemide, albumin and blood. Thirty six large nubian cross ungulates were subjected to CPB to test their capacity to act as oxygen yielding blood substitutes capable of reducing anasarca. A hyperosmolar oxygen-yielding blood substitute is feasible for CPB to enhance brain oxygenation and diminish anasarca. It decreases anasarca more than normo-osmolar crystalloid prime combined with hetastarch, mannitol, and furosemide. A large portion of the perfluorocarbon can be retrieved post-operatively.

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M3 - Conference article

AN - SCOPUS:0028533391

SN - 1073-1199

VL - 22

SP - A154

JO - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

JF - Artificial Cells, Blood Substitutes, and Immobilization Biotechnology

IS - 5

T2 - Proceedings of the 11th Congress of the International Society for Artificial Cells, Blood Substitutes and Immobilization Biotechnology, (ISABI)

Y2 - 24 July 1994 through 27 July 1994

ER -

A hyperosmolar oxygen yielding blood substitute for cardiopulmonary bypass

Abstract

ASJC Scopus subject areas

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