A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)

Alan Y. Sakaguchi; T. Mohandas; Susan L. Naylor

doi:10.1016/0165-4608(85)90062-7

A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)

Alan Y. Sakaguchi, T. Mohandas, Susan L. Naylor

Department of Cell Systems & Anatomy

Research output: Contribution to journal › Article › peer-review

5 Scopus citations

Abstract

A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.

Original language	English (US)
Pages (from-to)	123-129
Number of pages	7
Journal	Cancer Genetics and Cytogenetics
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(85)90062-7
State	Published - Oct 1985

ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

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10.1016/0165-4608(85)90062-7

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@article{c3a55818e5dc45d79b5b3134fdd8f057,

title = "A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)",

abstract = "A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome \#20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.",

author = "Sakaguchi, \{Alan Y.\} and T. Mohandas and Naylor, \{Susan L.\}",

note = "Funding Information: Theses tudiesw erei nitiatedin the Departmenotf HumanG eneticsR, oswellP arkMemorial InstituteB, uffalo,N Y. We thankD rs.T . B. Showsa ndM. Woodworthfo r use of equipment and facilities.W e alsot hankJ. M. Bishopa ndc olleaguefso r the pSRA-2 clone,A nneMarie Bell for technicaals sistancae,n dC. Bell, J. Gilliam,a ndM icheleC lary for typingt hemanu-script. This work was supportebdy AmericanC ancerS ocietyI nstitutionaAlw ardI N54W-7a nd ResearchG rantR O1 CA39186fr omt heN ationaIln stituteosf Health( to A. Y. S.).",

year = "1985",

month = oct,

doi = "10.1016/0165-4608(85)90062-7",

language = "English (US)",

volume = "18",

pages = "123--129",

journal = "Cancer Genetics and Cytogenetics",

issn = "0165-4608",

publisher = "Elsevier Inc.",

number = "2",

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T1 - A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)

AU - Sakaguchi, Alan Y.

AU - Mohandas, T.

AU - Naylor, Susan L.

N1 - Funding Information: Theses tudiesw erei nitiatedin the Departmenotf HumanG eneticsR, oswellP arkMemorial InstituteB, uffalo,N Y. We thankD rs.T . B. Showsa ndM. Woodworthfo r use of equipment and facilities.W e alsot hankJ. M. Bishopa ndc olleaguefso r the pSRA-2 clone,A nneMarie Bell for technicaals sistancae,n dC. Bell, J. Gilliam,a ndM icheleC lary for typingt hemanu-script. This work was supportebdy AmericanC ancerS ocietyI nstitutionaAlw ardI N54W-7a nd ResearchG rantR O1 CA39186fr omt heN ationaIln stituteosf Health( to A. Y. S.).

PY - 1985/10

Y1 - 1985/10

N2 - A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.

AB - A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.

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AN - SCOPUS:0022238246

SN - 0165-4608

VL - 18

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JO - Cancer Genetics and Cytogenetics

JF - Cancer Genetics and Cytogenetics

IS - 2

ER -

A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)

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