A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)

Alan Y Sakaguchi, T. Mohandas, Susan L. Naylor

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Original languageEnglish
Pages (from-to)123-129
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume18
Issue number2
DOIs
StatePublished - 1985

Fingerprint

src Genes
Chromosomes, Human, Pair 20
DNA
Rous sarcoma virus
Hybrid Cells
Rodentia
Clone Cells
Chromosomes

ASJC Scopus subject areas

  • Cancer Research
  • Genetics
  • Molecular Biology

Cite this

A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131). / Sakaguchi, Alan Y; Mohandas, T.; Naylor, Susan L.

In: Cancer Genetics and Cytogenetics, Vol. 18, No. 2, 1985, p. 123-129.

Research output: Contribution to journalArticle

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title = "A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)",
abstract = "A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.",
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AU - Mohandas, T.

AU - Naylor, Susan L.

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N2 - A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.

AB - A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.

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