A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)

Alan Y. Sakaguchi, T. Mohandas, Susan L. Naylor

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.

Original languageEnglish (US)
Pages (from-to)123-129
Number of pages7
JournalCancer Genetics and Cytogenetics
Volume18
Issue number2
DOIs
StatePublished - Oct 1985

ASJC Scopus subject areas

  • Molecular Biology
  • Genetics
  • Cancer Research

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