TY - JOUR
T1 - A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)
AU - Sakaguchi, Alan Y.
AU - Mohandas, T.
AU - Naylor, Susan L.
PY - 1985/10
Y1 - 1985/10
N2 - A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.
AB - A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.
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U2 - 10.1016/0165-4608(85)90062-7
DO - 10.1016/0165-4608(85)90062-7
M3 - Article
C2 - 2996754
AN - SCOPUS:0022238246
VL - 18
SP - 123
EP - 129
JO - Cancer Genetics and Cytogenetics
JF - Cancer Genetics and Cytogenetics
SN - 0165-4608
IS - 2
ER -