Abstract
A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 123-129 |
| Number of pages | 7 |
| Journal | Cancer Genetics and Cytogenetics |
| Volume | 18 |
| Issue number | 2 |
| DOIs | |
| State | Published - Oct 1985 |
ASJC Scopus subject areas
- Molecular Biology
- Genetics
- Cancer Research
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Sakaguchi, A. Y., Mohandas, T., & Naylor, S. L. (1985). A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131). Cancer Genetics and Cytogenetics, 18(2), 123-129. https://doi.org/10.1016/0165-4608(85)90062-7