A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)

Alan Y. Sakaguchi; T. Mohandas; Susan L. Naylor

doi:10.1016/0165-4608(85)90062-7

A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131)

Alan Y. Sakaguchi, T. Mohandas, Susan L. Naylor

Cell Systems & Anatomy

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4 Scopus citations

Abstract

A molecular clone of v-src, the oncogene of Rous sarcoma virus, was used to detect and regionally localize a human c-src proto-oncogene on chromosome #20. The human c-src gene, detected as either a 28-kbp EcoRI DNA fragment or as a 15.4-kbp BglII DNA fragment, was localized to 20 cen→q131 by filter hybridization analysis of DNAs from human-rodent somatic cell hybrids. The results indicate that c-src is on the same chromosome arm as aberrations associated with myeloproliferative disease, although the possible involvement of c-src in these aberrations is unknown.

Original language	English (US)
Pages (from-to)	123-129
Number of pages	7
Journal	Cancer Genetics and Cytogenetics
Volume	18
Issue number	2
DOIs	https://doi.org/10.1016/0165-4608(85)90062-7
Publication status	Published - Oct 1985

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ASJC Scopus subject areas

Molecular Biology
Genetics
Cancer Research

Cite this

Sakaguchi, A. Y., Mohandas, T., & Naylor, S. L. (1985). A human c-src gene resides on the proximal long arm of chromosome 20 (cen→q131). Cancer Genetics and Cytogenetics, 18(2), 123-129. https://doi.org/10.1016/0165-4608(85)90062-7

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10.1016/0165-4608(85)90062-7