A highly active gastric secretagogue extracted from a metastasis of a zollinger-ellison tumor - Report of a case

Basil I. Hirschowitz, S. Schenker, June D. Boyett

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

A highly potent gastric secretagogue has been extracted from a metastasis of a pancreatic tumor of the Zollinger-Ellison type using extraction procedures which were different from those reported by others. The response to various fractions of the tumor material in dogs with fistulas was characterized by prolonged secretion times, by output of acid which was greater than could be obtained with large single doses of histamine, and by a very marked stimulation of pepsin secretion which was in the range seen with insulin stimulation. The latter phenomenon distinguishes the active substance we tested from the gastrin or gastrin-like material extracted by others from either hog antrum or from Zollinger-Ellison tumors.

Original languageEnglish (US)
Pages (from-to)499-508
Number of pages10
JournalThe American Journal of Digestive Diseases
Volume8
Issue number6
DOIs
StatePublished - Jun 1963
Externally publishedYes

ASJC Scopus subject areas

  • Gastroenterology

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