A high-throughput chemical screen with FDA approved drugs reveals that the antihypertensive drug Spironolactone impairs cancer cell survival by inhibiting homology directed repair

Or David Shahar, Alkmini Kalousi, Lital Eini, Benoit Fisher, Amelie Weiss, Jonatan Darr, Olga Mazina, Shay Bramson, Martin Kupiec, Amir Eden, Eran Meshorer, Alexander V. Mazin, Laurent Brino, Michal Goldberg, Evi Soutoglou

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Pharmacology, Toxicology and Pharmaceutical Science

Biochemistry, Genetics and Molecular Biology