A hierarchy of T cell receptor motifs determines responsiveness to the immunodominant epitope in experimental autoimmune myasthenia gravis

Nathan E. Standifer, Ellen Kraig, Anthony J. Infante

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

The predominant murine T lymphocyte population responding to Tα146-162, the immunodominant epitope in EAMG, expresses the TCRBV 6 gene segment. However, cells expressing other TCRBV gene segments also react with this peptide. In order to more precisely characterize the Tα146-162- specific TCR repertoire, we isolated CD4high cells from peptide-immunized mice. The majority of CD4high cells utilized an acidic TCR β chain CDR3 motif regardless of TCRBV gene usage. Analysis of T cell clones demonstrated a fourfold higher avidity of Vβ6+ than non-Vβ6 cells for Tα146-162 indicating that a hierarchy of TCR motifs determines T cell responsiveness in EAMG.

Original languageEnglish (US)
Pages (from-to)68-76
Number of pages9
JournalJournal of Neuroimmunology
Volume145
Issue number1-2
DOIs
StatePublished - Dec 2003

Keywords

  • Avidity
  • Myasthenia gravis
  • T cell receptor
  • T lymphocytes

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Neurology
  • Clinical Neurology

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