A green approach toward quinoxalines and bis-quinoxalines and their biological evaluation against A431, human skin cancer cell lines

Debasish Bandyopadhyay, Jessica Cruz, Liza D. Morales, Hadi D. Arman, Erica Cuate, Young S. Lee, Bimal K. Banik, Dae J. Kim

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

Background: The objective of this study was to develop a practical green procedure to synthesize quinoxalines and bis-quinoxalines and evaluate their inhibitory effects on the viability of A431 human epidermoid carcinoma cells. Method: A series of quinoxaline and bis-quinoxaline derivatives have been designed and synthesized following a microwave-assisted and bismuth nitrate-catalyzed eco-friendly route. A detailed comparison has been made between microwave-induced protocol with the reactions occurred at room temperature. The structure of the compounds have been elucidated by various spectroscopic methods and finally confirmed by x-ray crystallographic analyses. Results: Two quinoxaline derivatives, compounds 6 and 12 have demonstrated inhibitory effects on the viability of A431 human epidermoid carcinoma cells when compared with HaCaT nontumorigenic human keratinocyte cells. Conclusion: Notably, compound 6 inhibits Stat3 phosphorylation/activation in A431 skin cancer cells.

Original languageEnglish (US)
Pages (from-to)1377-1390
Number of pages14
JournalFuture Medicinal Chemistry
Volume5
Issue number12
DOIs
StatePublished - Aug 2013

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology
  • Drug Discovery

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