A graphic user interface toolkit for specification, report and comparison of dose-response relations and treatment plans using the biologically effective uniform dose

Fan Chi Su, Panayiotis Mavroidis, Chengyu Shi, Brigida Costa Ferreira, Niko Papanikolaou

Research output: Contribution to journalArticle

8 Scopus citations

Abstract

A toolkit (BEUDcal) has been developed for evaluating the effectiveness and for predicting the outcome of treatment plans by calculating the biologically effective uniform dose (BEUD) and complication-free tumor control probability. The input for the BEUDcal is the differential dose-volume histograms of organs exported from the treatment planning system. A clinical database is built for the dose-response parameters of different tumors and normal tissues. Dose-response probabilities of all the examined organs are illustrated together with the corresponding BEUDs and the P+ values. Furthermore, BEUDcal is able to generate a report that simultaneously presents the radiobiological evaluation together with the physical dose indices, showing the complementary relation between the physical and radiobiological treatment plan analysis performed by BEUDcal. Comparisons between treatment plans for helical tomotherapy and multileaf collimator-based intensity modulated radiotherapy of a lung patient were demonstrated to show the versatility of BEUDcal in the assessment and report of dose-response relations.

Original languageEnglish (US)
Pages (from-to)69-78
Number of pages10
JournalComputer Methods and Programs in Biomedicine
Volume100
Issue number1
DOIs
StatePublished - Oct 1 2010

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Keywords

  • Biologically effective uniform dose
  • Helical tomotherapy
  • Radiobiological objectives
  • Treatment planning

ASJC Scopus subject areas

  • Software
  • Computer Science Applications
  • Health Informatics

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