A gonadotrophin-releasing hormone (GnRH) antagonist inhibits GnRH-but not LH-induced meiosis in follicle-enclosed rat oocytes in vitro

C. Ekholm, T. Hillensjo, W. J. Le Maire, C. Magnusson, C. S. Sheela Rani

Research output: Contribution to journalArticle

13 Scopus citations

Abstract

Previous studies have shown that gonadotrophin-releasing hormone (GnRH) can induce resumption of meiosis in follicle-enclosed rat oocytes. In the present study a GnRH antagonistic analogue ([D-pGlul,D-Phe2,-D-Trp3,6]LRF) was found to effectively abolish the stimulatory effect of a GnRH agonist upon resumption of meiosis and lactate accumulation in isolated pre-ovulatory rat follicles but they have no effect on LH stimulation of these parameters. It is concluded that although LH and GnRH can evoke a similar response they act through separate receptor sites and that it is unlikely that GnRH mediates the effect of LH on meiosis or glycolysis.

Original languageEnglish (US)
Pages (from-to)264-267
Number of pages4
JournalUnknown Journal
Volume101
Issue number2
DOIs
StatePublished - 1982
Externally publishedYes

ASJC Scopus subject areas

  • Endocrinology

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