A geropathology approach for identifying therapeutic targets to prevent pathological complications of COVID-19

Warren Ladiges, Yuji Ikeno, Liang Wang, Feng Liu

Research output: Contribution to journalComment/debatepeer-review

1 Scopus citations

Abstract

Vitally important aspects of dealing with the COVID-19 pandemic include the development of effective treatments for acute illness and prevention of infection. However, severe complications including mortality occur primarily in older adults, so a long-term approach of covering all aspects of infection and disease complications in older people is equally essential in preventing the alarming morbidity and mortality. Since severe pathological consequences of SARS-CoV-2 infection are age-related, a geropathology based platform of identifying age-related anatomic and molecular lesions aligned with processes of aging will be able to identify multiple targets for combinations of anti-aging drugs. A comprehensive geropathology-driven therapeutic approach of covering complications and vaccine effectiveness by enhancing resilience to aging will therefore play a critical role in preventing the alarming medical complications of disease not only with SARS-CoV-2 but also serve as a model for successfully controlling and preventing future world-wide pandemics.

Original languageEnglish (US)
Pages (from-to)106-108
Number of pages3
JournalAging Pathobiology and Therapeutics
Volume2
Issue number2
DOIs
StatePublished - 2020

Keywords

  • COVID-19 complications
  • geropathology
  • Resilience to aging
  • SARS-CoV-2 pathology

ASJC Scopus subject areas

  • Geriatrics and Gerontology
  • Cellular and Molecular Neuroscience
  • Pharmacology, Toxicology and Pharmaceutics (miscellaneous)
  • Drug Discovery

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