Abstract
Background - Fibrinogen levels are a widely accepted risk factor for cardiovascular disease, but the extent of the genetic component is unknown. Materials and Results - To search for these genes, we conducted a genome-wide scan using 21 Spanish families from the Genetic Analysis of Idiopathic Thrombophila (GAIT) Project. Two loci were detected: 1 on chromosome 12 and another on chromosome 14. There are no cardiovascular-related candidate genes on chromosome 14, which implies that this locus represents a novel cardiovascular risk factor. Importantly, the locus on chromosome 12 contains the hepatocyte nuclear factors (TCF1), a candidate gene involved in the hepatocyte-specific transcription of the fibrinogen α-chain and β-chain genes. Three polymorphisms in TCF1 showed significant association with fibrinogen levels, supporting the implication of TCF1 in the determination of this phenotype. Conclusions - Two loci, 1 on chromosome 12 (most likely the TCF1) and another on chromosome 14, are important determinants of fibrinogen levels in Spanish families. These data should help define the relationship between fibrinogen levels and the risk of cardiovascular disease.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 1287-1292 |
| Number of pages | 6 |
| Journal | Arteriosclerosis, Thrombosis, and Vascular Biology |
| Volume | 25 |
| Issue number | 6 |
| DOIs | |
| State | Published - Jun 2005 |
| Externally published | Yes |
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Keywords
- Fibrinogen and TCF1 gene
- GAIT Project
- Quantitative trait locus
- Thrombosis
ASJC Scopus subject areas
- Cardiology and Cardiovascular Medicine
Cite this
A genome search for genetic determinants that influence plasma fibrinogen levels. / Soria, José Manuel; Almasy, Laura; Souto, Juan Carlos; Buil, Alfonso; Lathrop, Mark; Blangero, John; Fontcuberta, Jordi.
In: Arteriosclerosis, Thrombosis, and Vascular Biology, Vol. 25, No. 6, 06.2005, p. 1287-1292.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - A genome search for genetic determinants that influence plasma fibrinogen levels
AU - Soria, José Manuel
AU - Almasy, Laura
AU - Souto, Juan Carlos
AU - Buil, Alfonso
AU - Lathrop, Mark
AU - Blangero, John
AU - Fontcuberta, Jordi
PY - 2005/6
Y1 - 2005/6
N2 - Background - Fibrinogen levels are a widely accepted risk factor for cardiovascular disease, but the extent of the genetic component is unknown. Materials and Results - To search for these genes, we conducted a genome-wide scan using 21 Spanish families from the Genetic Analysis of Idiopathic Thrombophila (GAIT) Project. Two loci were detected: 1 on chromosome 12 and another on chromosome 14. There are no cardiovascular-related candidate genes on chromosome 14, which implies that this locus represents a novel cardiovascular risk factor. Importantly, the locus on chromosome 12 contains the hepatocyte nuclear factors (TCF1), a candidate gene involved in the hepatocyte-specific transcription of the fibrinogen α-chain and β-chain genes. Three polymorphisms in TCF1 showed significant association with fibrinogen levels, supporting the implication of TCF1 in the determination of this phenotype. Conclusions - Two loci, 1 on chromosome 12 (most likely the TCF1) and another on chromosome 14, are important determinants of fibrinogen levels in Spanish families. These data should help define the relationship between fibrinogen levels and the risk of cardiovascular disease.
AB - Background - Fibrinogen levels are a widely accepted risk factor for cardiovascular disease, but the extent of the genetic component is unknown. Materials and Results - To search for these genes, we conducted a genome-wide scan using 21 Spanish families from the Genetic Analysis of Idiopathic Thrombophila (GAIT) Project. Two loci were detected: 1 on chromosome 12 and another on chromosome 14. There are no cardiovascular-related candidate genes on chromosome 14, which implies that this locus represents a novel cardiovascular risk factor. Importantly, the locus on chromosome 12 contains the hepatocyte nuclear factors (TCF1), a candidate gene involved in the hepatocyte-specific transcription of the fibrinogen α-chain and β-chain genes. Three polymorphisms in TCF1 showed significant association with fibrinogen levels, supporting the implication of TCF1 in the determination of this phenotype. Conclusions - Two loci, 1 on chromosome 12 (most likely the TCF1) and another on chromosome 14, are important determinants of fibrinogen levels in Spanish families. These data should help define the relationship between fibrinogen levels and the risk of cardiovascular disease.
KW - Fibrinogen and TCF1 gene
KW - GAIT Project
KW - Quantitative trait locus
KW - Thrombosis
UR - http://www.scopus.com/inward/record.url?scp=20144367081&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=20144367081&partnerID=8YFLogxK
U2 - 10.1161/01.ATV.0000161927.38739.6f
DO - 10.1161/01.ATV.0000161927.38739.6f
M3 - Article
C2 - 15761192
AN - SCOPUS:20144367081
VL - 25
SP - 1287
EP - 1292
JO - Arteriosclerosis, Thrombosis, and Vascular Biology
JF - Arteriosclerosis, Thrombosis, and Vascular Biology
SN - 1079-5642
IS - 6
ER -