A genetic epidemiologic perspective on comorbidity of depression and anxiety

Douglas E. Williamson, Erika E. Forbes, Ronald E. Dahl, Neal D. Ryan

Research output: Contribution to journalReview article

29 Scopus citations

Abstract

Current research indicates that there is a strong relationship between the depression and anxiety that first appear during childhood. Both depression and anxiety co-segregate in families, indicating that the familial risk for the two disorders is shared. Epidemiologic and clinical evidence has shown that anxiety often precedes the onset of depression and the two disorders share a common genetic pathway that may be expressed differentially across development. From a preventive health perspective, children with depressed or anxious relatives are at increased risk for developing anxiety or depression. In addition, anxious children are at increased risk for developing depression particularly during adolescence.

Original languageEnglish (US)
Pages (from-to)707-726
Number of pages20
JournalChild and Adolescent Psychiatric Clinics of North America
Volume14
Issue number4
DOIs
StatePublished - Oct 1 2005

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Psychiatry and Mental health

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