A genetic and epidemiologic study of cardiovascular disease in Alaska natives (GOCADAN): design and methods.

Barbara V. Howard, Richard B. Devereux, Shelley A. Cole, Michael Davidson, Bennett Dyke, Sven O.E. Ebbesson, Stephen E. Epstein, David R. Robinson, Betty Jarvis, David J. Kaufman, Sandra Laston, Jean W. MacCluer, Peter M. Okin, Mary J. Roman, Terry Romenesko, Giacomo Ruotolo, Michael Swenson, Charlotte R. Wenger, Sarah Williams-Blangero, Jianhui ZhuClarence Saccheus, Richard R. Fabsitz, David C. Robbins

    Research output: Contribution to journalArticlepeer-review

    45 Scopus citations


    This article is a report of the design and methods of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study. This longitudinal, population-based study was initiated to investigate the genetic determinants of cardiovascular disease and its risk factors. Between October 2000 and April 2004, this family study enrolled 1,214 Eskimos from several coastal villages in the Norton Sound region of Western Alaska. Examinations included a physical, laboratory determinations, and measures of subclinical disease. This study will generate a genome-wide scan for loci influencing cardiovascular disease-related traits. Relations between subclinical atherosclerosis and markers of inflammation will be examined using historic and newly drawn samples. The study will provide data on CVD prevalence, risk factors and the relative contribution of genetic and environmental determinants in Alaska Native peoples. Data from this study will contribute to the delivery of health-care and prevention of CVD in Alaska Eskimos and other populations.

    Original languageEnglish (US)
    Pages (from-to)206-221
    Number of pages16
    JournalInternational journal of circumpolar health
    Issue number3
    StatePublished - Jun 2005

    ASJC Scopus subject areas

    • Epidemiology
    • Health(social science)
    • Public Health, Environmental and Occupational Health


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