A further study of the cytotoxic constituents of a milnamide-producing sponge

Rachel N. Sonnenschein; Jarrett J. Farias; Karen Tenney; Susan L. Mooberry; Emil Lobkovsky; Jon Clardy; Phillip Crews

doi:10.1021/ol036446c

A further study of the cytotoxic constituents of a milnamide-producing sponge

Rachel N. Sonnenschein, Jarrett J. Farias, Karen Tenney, Susan L. Mooberry, Emil Lobkovsky, Jon Clardy, Phillip Crews

Research output: Contribution to journal › Article › peer-review

37 Scopus citations

Abstract

A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here.

Original language	English (US)
Pages (from-to)	779-782
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	5
DOIs	https://doi.org/10.1021/ol036446c
State	Published - Mar 4 2004
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

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10.1021/ol036446c

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abstract = "A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here.",

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T1 - A further study of the cytotoxic constituents of a milnamide-producing sponge

AU - Sonnenschein, Rachel N.

AU - Farias, Jarrett J.

AU - Tenney, Karen

AU - Mooberry, Susan L.

AU - Lobkovsky, Emil

AU - Clardy, Jon

AU - Crews, Phillip

PY - 2004/3/4

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AB - A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here.

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A further study of the cytotoxic constituents of a milnamide-producing sponge

Abstract

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