A further study of the cytotoxic constituents of a milnamide-producing sponge

Rachel N. Sonnenschein, Jarrett J. Farias, Karen Tenney, Susan L. Mooberry, Emil Lobkovsky, Jon Clardy, Phillip Crews

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Abstract

A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here.

Original languageEnglish (US)
Pages (from-to)779-782
Number of pages4
JournalOrganic Letters
Volume6
Issue number5
DOIs
Publication statusPublished - Mar 4 2004

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ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

Cite this

Sonnenschein, R. N., Farias, J. J., Tenney, K., Mooberry, S. L., Lobkovsky, E., Clardy, J., & Crews, P. (2004). A further study of the cytotoxic constituents of a milnamide-producing sponge. Organic Letters, 6(5), 779-782. https://doi.org/10.1021/ol036446c