A further study of the cytotoxic constituents of a milnamide-producing sponge

Rachel N. Sonnenschein; Jarrett J. Farias; Karen Tenney; Susan L. Mooberry; Emil Lobkovsky; Jon Clardy; Phillip Crews

doi:10.1021/ol036446c

A further study of the cytotoxic constituents of a milnamide-producing sponge

Rachel N. Sonnenschein, Jarrett J. Farias, Karen Tenney, Susan L. Mooberry, Emil Lobkovsky, Jon Clardy, Phillip Crews

Research output: Contribution to journal › Article › peer-review

35 Scopus citations

Abstract

A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here.

Original language	English (US)
Pages (from-to)	779-782
Number of pages	4
Journal	Organic Letters
Volume	6
Issue number	5
DOIs	https://doi.org/10.1021/ol036446c
State	Published - Mar 4 2004
Externally published	Yes

ASJC Scopus subject areas

Biochemistry
Physical and Theoretical Chemistry
Organic Chemistry

Access to Document

10.1021/ol036446c

Fingerprint Dive into the research topics of 'A further study of the cytotoxic constituents of a milnamide-producing sponge'. Together they form a unique fingerprint.

Cite this

@article{99b551d8b53d42e892b833d99bb1496d,

title = "A further study of the cytotoxic constituents of a milnamide-producing sponge",

abstract = "A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here.",

author = "Sonnenschein, {Rachel N.} and Farias, {Jarrett J.} and Karen Tenney and Mooberry, {Susan L.} and Emil Lobkovsky and Jon Clardy and Phillip Crews",

year = "2004",

month = mar,

day = "4",

doi = "10.1021/ol036446c",

language = "English (US)",

volume = "6",

pages = "779--782",

journal = "Organic Letters",

issn = "1523-7060",

publisher = "American Chemical Society",

number = "5",

}

TY - JOUR

T1 - A further study of the cytotoxic constituents of a milnamide-producing sponge

AU - Sonnenschein, Rachel N.

AU - Farias, Jarrett J.

AU - Tenney, Karen

AU - Mooberry, Susan L.

AU - Lobkovsky, Emil

AU - Clardy, Jon

AU - Crews, Phillip

PY - 2004/3/4

Y1 - 2004/3/4

N2 - A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here.

AB - A reinvestigation of Auletta sp. yielded the novel compound milnamide C (3) plus the known compounds milnamide A (1), milnamide B (hemiasterlin) (2), jasplakinolide (5), and geodiamolides A (6), D (7), E (8), and G (9). The isolation work was guided by cytoskeletal bioactivity data. Compounds 2 and 3 were shown to cause microtubule depolymerization, and 6-9 were shown to cause microfilament disruption. This biological activity and the structural elucidation of 3, including X-ray analysis, are reported here.

UR - http://www.scopus.com/inward/record.url?scp=1642333001&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=1642333001&partnerID=8YFLogxK

U2 - 10.1021/ol036446c

DO - 10.1021/ol036446c

M3 - Article

C2 - 14986973

AN - SCOPUS:1642333001

VL - 6

SP - 779

EP - 782

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 5

ER -