A four-hour topotecan infusion achieves cytotoxic exposure throughout the neuraxis in the nonhuman primate model: Implications for treatment of children with metastatic medulloblastoma

William C. Zamboni, Amar J. Gajjar, Timothy D. Mandrell, Stephanie L. Einhaus, Mary K. Danks, William P. Rogers, Richard L. Heideman, Peter J. Houghton, Clinton F. Stewart

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