A four-dimensional probabilistic atlas of the human brain

J. Mazziotta, A. Toga, A. Evans, P. Fox, J. Lancaster, K. Zilles, R. Woods, T. Paus, G. Simpson, B. Pike, C. Holmes, L. Collins, P. Thompson, D. MacDonald, M. Iacoboni, T. Schormann, K. Amunts, N. Palomero-Gallagher, S. Geyer, L. ParsonsK. Narr, N. Kabani, G. Le Goualher, J. Feidler, K. Smith, D. Boomsma, H. H. Pol, T. Cannon, R. Kawashima, B. Mazoyer

Research output: Contribution to journalReview articlepeer-review

218 Scopus citations

Abstract

The authors describe the development of a four-dimensional atlas and reference system that includes both macroscopic and microscopic information on structure and function of the human brain in persons between the ages of 18 and 90 years. Given the presumed large but previously unquantified degree of structural and functional variance among normal persons in the human population, the basis for this atlas and reference system is probabilistic. Through the efforts of the International Consortium for Brain Mapping (ICBM), 7,000 subjects will be included in the initial phase of database and atlas development. For each subject, detailed demographic, clinical, behavioral, and imaging information is being collected. In addition, 5,800 subjects will contribute DNA for the purpose of determining genotype-phenotype-behavioral correlations. The process of developing the strategies, algorithms, data collection methods, validation approaches, database structures, and distribution of results is described in this report. Examples of applications of the approach are described for the normal brain in both adults and children as well as in patients with schizophrenia. This project should provide new insights into the relationship between microscopic and macroscopic structure and function in the human brain and should have important implications in basic neuroscience, clinical diagnostics, and cerebral disorders.

Original languageEnglish (US)
Pages (from-to)401-430
Number of pages30
JournalJournal of the American Medical Informatics Association
Volume8
Issue number5
DOIs
StatePublished - 2001

ASJC Scopus subject areas

  • Health Informatics

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