A follow-up study of colonic epithelial proliferation as a biomarker in a native-American family with hereditary nonpolyposis colon cancer

P. M. Lynch, Michael J Wargovich, H. T. Lynch, C. Palmer, S. Lanspa, T. Drouhard, J. Lynch

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

A 7-year follow-up study of colonic mucosa proliferation markers was conducted on members of a Native-American family with hereditary nonpoly posis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7-year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and followup values for epithelial proliferation were within the accepted normal range. The presence of essentially normal labeling indexes among colon cancer patients and their high-risk off-spring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterizes the Native-American population in the American Southwest.

Original languageEnglish (US)
Pages (from-to)951-954
Number of pages4
JournalJournal of the National Cancer Institute
Volume83
Issue number13
StatePublished - Jul 3 1991
Externally publishedYes

Fingerprint

Hereditary Nonpolyposis Colorectal Neoplasms
North American Indians
Biomarkers
Proliferation
Colonic Neoplasms
Labeling
Cancer
Thymidine
Assays
Confounding
Reproducibility
Bromodeoxyuridine
Autoradiography
Immunoenzyme Techniques
Baseline
Preparation
Colon
Reference Values
Mucous Membrane
Staining and Labeling

ASJC Scopus subject areas

  • Cancer Research
  • Oncology
  • Statistics, Probability and Uncertainty
  • Applied Mathematics
  • Physiology (medical)
  • Radiology Nuclear Medicine and imaging

Cite this

A follow-up study of colonic epithelial proliferation as a biomarker in a native-American family with hereditary nonpolyposis colon cancer. / Lynch, P. M.; Wargovich, Michael J; Lynch, H. T.; Palmer, C.; Lanspa, S.; Drouhard, T.; Lynch, J.

In: Journal of the National Cancer Institute, Vol. 83, No. 13, 03.07.1991, p. 951-954.

Research output: Contribution to journalArticle

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