A follow-up study of colonic epithelial proliferation as a biomarker in a native-american family with hereditary nonpolyposis colon cancer

P. M. Lynch, M. J. Wargovich, H. T. Lynch, C. Palmer, S. Lanspa, T. Drouhard, J. Lynch

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18 Scopus citations


A 7-year follow-up study of colonic mucosa proliferation markers was conducted on members of a Native-American family with hereditary non-polyposis colon cancer. Reproducibility of a tritiated thymidine autoradiography assay for labeling indexes during this 7-year biologically significant time frame was established. A good correlation between tritiated thymidine and a newer technique, bromodeoxyuridine immunoperoxidase staining, was seen. No confounding effect could be attributed to standard colon preparation. On average, both baseline and follow-up values for epithelial proliferation were within the accepted normalrange. The presence of essentially normal labeling indexes among colon cancer patients and their high-risk offspring suggests the possibility of the significant effect of dietary factors in reducing proliferation. Such factors may account for the low risk of colon cancer that characterzies the Native-American population in the American Southwest. [J Natl Cancer Inst 83: 951-954, 1991].

Original languageEnglish (US)
Pages (from-to)951-954
Number of pages4
JournalJournal of the National Cancer Institute
Issue number13
StatePublished - Jul 3 1991
Externally publishedYes


ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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