A DNA polymorphism for lecithin: cholesterol acyltransferase (LCAT) is associated with high density lipoprotein cholesterol concentrations in baboons

Candace M. Kammerer, James E. Hixson, Glen E. Mott

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

We investigated the effects of a polymorphic PvuII site in the gene for lecithin:cholesterol acyltransferase (LCAT) on serum high density lipoprotein cholesterol (HDL-C) and apolipoprotein A-I (apo A-I) concentrations in a population of 750 pedigreed baboons. We also tested for genotype by diet interactions using data on HDL-C and apo A-I concentrations on two diets (chow and high-cholesterol, saturated fat). A significant (P < 0.001) association between the LCAT genotypes and HDL-C levels was observed. On both diets, animals homozygous for the less common allele had HDL-C levels that averaged 18-19% lower than animals homozygous for the more common allele. HDL-C levels of the heterozygotes were intermediate. The LCAT RFLP accounted for approximately 5% of the variation in HDL-C levels on the two diets. We observed no strong evidence for an LCAT genotype by diet interaction effect.

Original languageEnglish (US)
Pages (from-to)153-163
Number of pages11
JournalAtherosclerosis
Volume98
Issue number2
DOIs
StatePublished - Jan 25 1993

Keywords

  • Association study
  • HDL cholesterol
  • LCAT

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

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