A different depression

Clinical distinctions between bipolar and unipolar depression

Charles L. Bowden

Research output: Contribution to journalArticle

127 Citations (Scopus)

Abstract

Delayed diagnosis or misdiagnosis can prolong the suffering of patients with bipolar disorder. Accurate early diagnosis is sometimes difficult, however, particularly because patients often present in the depressive phase, which can easily be mistaken for unipolar depression. Unfortunately, therapy appropriate for unipolar depression can increase the risk of manic switch or cycle acceleration in bipolar disorder, especially in those with a family history of bipolarity and suicide, although some antidepressants may be useful in some bipolar patients. In addition, most currently available mood stabilizers, though effective in managing mania, do not effectively resolve depression. In contrast, lamotrigine has shown activity in bipolar depression and has a very low risk of manic switch. Bipolar depression, compared with unipolar depression, is more likely to be associated with hypersomnia, motor retardation, mood lability, early onset, and a family history of bipolar disorder. Awareness of these distinctions can greatly improve diagnosis of bipolar disorder and provide an opportunity for effective therapeutic intervention.

Original languageEnglish (US)
Pages (from-to)117-125
Number of pages9
JournalJournal of Affective Disorders
Volume84
Issue number2-3
DOIs
StatePublished - Feb 2005

Fingerprint

Depressive Disorder
Bipolar Disorder
Depression
Disorders of Excessive Somnolence
Delayed Diagnosis
Diagnostic Errors
Psychological Stress
Suicide
Antidepressive Agents
Early Diagnosis
Therapeutics

Keywords

  • Bipolar disorder
  • Depression
  • Diagnosis
  • Lamotrigine
  • Treatment

ASJC Scopus subject areas

  • Psychiatry and Mental health
  • Behavioral Neuroscience
  • Biological Psychiatry
  • Neurology
  • Psychology(all)

Cite this

A different depression : Clinical distinctions between bipolar and unipolar depression. / Bowden, Charles L.

In: Journal of Affective Disorders, Vol. 84, No. 2-3, 02.2005, p. 117-125.

Research output: Contribution to journalArticle

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