A detailed experimental and Monte Carlo analysis of gold nanoparticle dose enhancement using 6 MV and 18 MV external beam energies in a macroscopic scale

Tara Gray, Nema Bassiri, Shaquan David, Devanshi Yogeshkumar Patel, Sotirios Stathakis, Neil Kirby, Kathryn M. Mayer

Research output: Contribution to journalArticlepeer-review

Abstract

Dose enhancement due to gold nanoparticles (GNPs) has been quantified experimentally and through Monte Carlo simulations for external beam radiation therapy energies of 6 and 18 MV. The highest enhancement was observed for the 18 MV beam at the highest GNP concentration tested, amounting to a DEF of 1.02. DEF is shown to increase with increasing concentration of gold and increasing energy in the megavoltage energy range. The largest difference in measured vs. simulated DEF across all data sets was 0.3%, showing good agreement.

Original languageEnglish (US)
Article number109638
JournalApplied Radiation and Isotopes
Volume171
DOIs
StatePublished - May 2021

Keywords

  • Dose enhancement factor
  • Gold nanoparticles
  • Monte Carlo simulations
  • Radiation therapy

ASJC Scopus subject areas

  • Radiation

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