A Degenerative Form of Mixed Transcortical Aphasia

Leila Saadatpour, Usama Tariq, Alicia Parker, Leilani Doty, Kenneth M. Heilman

Research output: Contribution to journalArticlepeer-review


Mixed transcortical aphasia (MTA) is characterized by decreased spontaneous speech, impaired naming, and poor comprehension, but with intact repetition. MTA has been reported to be the sequela of left hemisphere watershed infarction that isolates Wernicke's perisylvian arc. We report a 55-year-old right-handed woman who began having word-finding difficulty and then gradually developed impaired spontaneous speech, comprehension, and naming, but with intact repetition. Magnetic resonance imaging showed atrophy in the left frontal, parietal, and temporal lobes. This patient demonstrates that MTA can occur as a result of neurodegenerative disease. Further research is needed to learn whether progressive MTA is a late stage of primary progressive aphasia, examine the neuropathology associated with this syndrome, and identify treatment strategies.

Original languageEnglish (US)
Pages (from-to)18-22
Number of pages5
JournalCognitive and Behavioral Neurology
Issue number1
StatePublished - 2018


  • aphasia
  • dementia
  • mixed transcortical aphasia
  • neurodegenerative disease
  • primary progressive aphasia

ASJC Scopus subject areas

  • Neuropsychology and Physiological Psychology
  • Cognitive Neuroscience
  • Psychiatry and Mental health


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