A dark strain in the Fusarium solani species complex isolated from primary subcutaneous sporotrichioid lesions associated with traumatic inoculation via a rose bush thorn

A. Serda Kantarcioglu, Richard C. Summerbell, Deanna A. Sutton, Ayhan Yücell, Ebru Sarikaya, Gültekin Kaner, Aydin Iscimen, Kemal Altas

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Fusarium species are hyaline hyphomycetes widely distributed in nature and documented agents of both superficial and systemic infections in humans. In this paper, we report a darkly-pigmented and initially non-sporulating isolate in the Fusarium solani species complex (FSSC) causing a post-traumatic sporotrichoid infection in an otherwise healthy, male patient. Sequencing of multiple loci showed that the isolate represented an otherwise unknown lineage, possibly corresponding to a separate species, within the multi-species F. solani complex. In prolonged culture, the non-sporulating isolate produced revertant wild-type subcultures with typical Fusarium conidiation. This suggests that the original dense, dark, non-sporulating isolate was a host-adapted form selected in vivo for characters compatible with human pathogenicity. The production of such forms by Fusarium species is increasingly recognized now that sequencing has allowed the identification of highly atypical isolates. In vitro antifungal susceptibility of the isolate was investigated against seven conventional and two newly approved antifungal agents. The isolate showed in vitro resistance to amphotericin B, but appeared susceptible to itraconazole and terbinafine. A cure was ultimately achieved with combined terbinafine/itraconazole therapy with prolonged itraconazole follow-up therapy.

Original languageEnglish (US)
Pages (from-to)103-109
Number of pages7
JournalMedical Mycology
Volume48
Issue number1
DOIs
StatePublished - 2010
Externally publishedYes

Fingerprint

lesions (plant)
itraconazole
plant spines
terbinafine
Fusarium solani
Fusarium
Itraconazole
Rosa
vaccination
therapeutics
antifungal agents
amphotericin B
Hyphomycetes
Mitosporic Fungi
infection
Hyalin
Antifungal Agents
Amphotericin B
pathogenicity
Infection

Keywords

  • Acid fast fungal cells
  • Chlamydospores
  • Fusarium solani species complex
  • Primary subcutaneous fusariosis
  • Sporotrichoid infection

ASJC Scopus subject areas

  • veterinary(all)
  • Infectious Diseases

Cite this

A dark strain in the Fusarium solani species complex isolated from primary subcutaneous sporotrichioid lesions associated with traumatic inoculation via a rose bush thorn. / Kantarcioglu, A. Serda; Summerbell, Richard C.; Sutton, Deanna A.; Yücell, Ayhan; Sarikaya, Ebru; Kaner, Gültekin; Iscimen, Aydin; Altas, Kemal.

In: Medical Mycology, Vol. 48, No. 1, 2010, p. 103-109.

Research output: Contribution to journalArticle

Kantarcioglu, A. Serda ; Summerbell, Richard C. ; Sutton, Deanna A. ; Yücell, Ayhan ; Sarikaya, Ebru ; Kaner, Gültekin ; Iscimen, Aydin ; Altas, Kemal. / A dark strain in the Fusarium solani species complex isolated from primary subcutaneous sporotrichioid lesions associated with traumatic inoculation via a rose bush thorn. In: Medical Mycology. 2010 ; Vol. 48, No. 1. pp. 103-109.
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