A counter antigonadotrophic effect of melatonin in male rats

R. J. Reiter, D. E. Blask, Mary K. Vaughan

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Blinding and anosmia in male rats is followed by retarded bodily development, reduced weights of the gonads and adnexa, and depressed levels of pituitary luteinizing hormone and prolactin. The effects of dual sensory deprivation are negated, for the most part, by either pinealectomy or the weekly subcutaneous implantation of melatonin (in beeswax). This is the first report that melatonin negates the antigonadotrophic influence of the rat pineal gland.

Original languageEnglish (US)
Pages (from-to)72-80
Number of pages9
Issue number1
StatePublished - 1975


  • Anosmia
  • Blinding
  • Luteinizing hormone
  • Melatonin
  • Pineal gland
  • Prolactin
  • Rat

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology
  • Endocrine and Autonomic Systems
  • Cellular and Molecular Neuroscience


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