A computational framework for predicting drug Mode-of-Action

Chifeng Ma, Yufei Huang, Hung I. Chen, Yidong Chen

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

The problem of large scale computational drug screening is considered in this paper. A computational framework is developed for microarray profile of drug treatment from the Connectivity Map (cMap) project. The framework is proposed to address the deficiency of cMap prediction. This scheme includes construction of drug Mode-of-Actions (MoA) and subsequently Mode-of-Action (MoA) network, or MoANet and a MoA prediction algorithm based on MoAs. The scheme is tested on the cMap data and an independent data set. The result shows significant improvement over cMap.

Original languageEnglish (US)
Title of host publication2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010
Pages374-379
Number of pages6
DOIs
StatePublished - 2010
Event2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010 - HongKong, China
Duration: Dec 18 2010Dec 21 2010

Other

Other2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010
CountryChina
CityHongKong
Period12/18/1012/21/10

Fingerprint

Preclinical Drug Evaluations
Pharmaceutical Preparations
Drug therapy
Microarrays
Screening
Datasets

Keywords

  • Drug activity prediction
  • Gene set selection
  • MoANet
  • Mode of Action

ASJC Scopus subject areas

  • Biomedical Engineering
  • Health Informatics

Cite this

Ma, C., Huang, Y., Chen, H. I., & Chen, Y. (2010). A computational framework for predicting drug Mode-of-Action. In 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010 (pp. 374-379). [5703831] https://doi.org/10.1109/BIBMW.2010.5703831

A computational framework for predicting drug Mode-of-Action. / Ma, Chifeng; Huang, Yufei; Chen, Hung I.; Chen, Yidong.

2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010. 2010. p. 374-379 5703831.

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Ma, C, Huang, Y, Chen, HI & Chen, Y 2010, A computational framework for predicting drug Mode-of-Action. in 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010., 5703831, pp. 374-379, 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010, HongKong, China, 12/18/10. https://doi.org/10.1109/BIBMW.2010.5703831
Ma C, Huang Y, Chen HI, Chen Y. A computational framework for predicting drug Mode-of-Action. In 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010. 2010. p. 374-379. 5703831 https://doi.org/10.1109/BIBMW.2010.5703831
Ma, Chifeng ; Huang, Yufei ; Chen, Hung I. ; Chen, Yidong. / A computational framework for predicting drug Mode-of-Action. 2010 IEEE International Conference on Bioinformatics and Biomedicine Workshops, BIBMW 2010. 2010. pp. 374-379
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