A Comprehensive Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

Srinivas Karra, Brian Sager, M. Nazmul Karim

Research output: Contribution to journalArticlepeer-review

Abstract

A population balance model that describes the inter cellular variations in metabolism with respect to cell cycle apportioning is combined with an unstructured average cell model and an intrinsic culture state model to quantify various intra and inter cellular phenomena in Chinese Hamster Ovary (CHO) cell cultures at laboratory scale. Model validation is performed on three sets of batch cultures of CHO cells in spinner flasks.

Original languageEnglish (US)
Pages (from-to)1311-1315
Number of pages5
JournalComputer Aided Chemical Engineering
Volume29
DOIs
StatePublished - 2011
Externally publishedYes

Keywords

  • Cell Cycle
  • Population Balance Model

ASJC Scopus subject areas

  • Chemical Engineering(all)
  • Computer Science Applications

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