A Comprehensive Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

Srinivas Karra; Brian Sager; M. Nazmul Karim

doi:10.1016/B978-0-444-54298-4.50041-6

A Comprehensive Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

Srinivas Karra, Brian Sager, M. Nazmul Karim

Research output: Contribution to journal › Article › peer-review

Abstract

A population balance model that describes the inter cellular variations in metabolism with respect to cell cycle apportioning is combined with an unstructured average cell model and an intrinsic culture state model to quantify various intra and inter cellular phenomena in Chinese Hamster Ovary (CHO) cell cultures at laboratory scale. Model validation is performed on three sets of batch cultures of CHO cells in spinner flasks.

Original language	English (US)
Pages (from-to)	1311-1315
Number of pages	5
Journal	Computer Aided Chemical Engineering
Volume	29
DOIs	https://doi.org/10.1016/B978-0-444-54298-4.50041-6
State	Published - 2011
Externally published	Yes

Keywords

Cell Cycle
Population Balance Model

ASJC Scopus subject areas

General Chemical Engineering
Computer Science Applications

Access to Document

10.1016/B978-0-444-54298-4.50041-6

Cite this

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title = "A Comprehensive Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes",

abstract = "A population balance model that describes the inter cellular variations in metabolism with respect to cell cycle apportioning is combined with an unstructured average cell model and an intrinsic culture state model to quantify various intra and inter cellular phenomena in Chinese Hamster Ovary (CHO) cell cultures at laboratory scale. Model validation is performed on three sets of batch cultures of CHO cells in spinner flasks.",

keywords = "Cell Cycle, Population Balance Model",

author = "Srinivas Karra and Brian Sager and {Nazmul Karim}, M.",

year = "2011",

doi = "10.1016/B978-0-444-54298-4.50041-6",

language = "English (US)",

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pages = "1311--1315",

journal = "Computer Aided Chemical Engineering",

issn = "1570-7946",

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T1 - A Comprehensive Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

AU - Karra, Srinivas

AU - Sager, Brian

AU - Nazmul Karim, M.

PY - 2011

Y1 - 2011

N2 - A population balance model that describes the inter cellular variations in metabolism with respect to cell cycle apportioning is combined with an unstructured average cell model and an intrinsic culture state model to quantify various intra and inter cellular phenomena in Chinese Hamster Ovary (CHO) cell cultures at laboratory scale. Model validation is performed on three sets of batch cultures of CHO cells in spinner flasks.

AB - A population balance model that describes the inter cellular variations in metabolism with respect to cell cycle apportioning is combined with an unstructured average cell model and an intrinsic culture state model to quantify various intra and inter cellular phenomena in Chinese Hamster Ovary (CHO) cell cultures at laboratory scale. Model validation is performed on three sets of batch cultures of CHO cells in spinner flasks.

KW - Cell Cycle

KW - Population Balance Model

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UR - http://www.scopus.com/inward/citedby.url?scp=79958826644&partnerID=8YFLogxK

U2 - 10.1016/B978-0-444-54298-4.50041-6

DO - 10.1016/B978-0-444-54298-4.50041-6

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AN - SCOPUS:79958826644

SN - 1570-7946

VL - 29

SP - 1311

EP - 1315

JO - Computer Aided Chemical Engineering

JF - Computer Aided Chemical Engineering

ER -

A Comprehensive Multi-Scale Modeling of Heterogeneities in Mammalian Cell Culture Processes

Abstract

Keywords

ASJC Scopus subject areas

Access to Document

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