A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions

S. E. Piwinski, J. Jankovic, M. A. McElligott

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

After space-flights of less than ten days, orthostatic hypotension upon reentry is characterized by plasma volume depletion that may lead to activation of the Bezold-Jarisch reflex which is also considered to be the mechanism of vasovagal (neurocardiogenic) syncope. For space-flight of longer duration, loss of cardiovascular reflex control may take precedence over volume depletion and thus may have similarities to the orthostatic hypotension seen in patients with autonomic failure secondary to basal ganglial disease and peripheral neuropathies. Midodrine is an alpha-one agonist that produces arterial and venous constriction and leads to a decrease in heart rate by baroreceptor reflexes. The efficacy of Midodrine in successfully treating orthostatic hypotension secondary to autonomic failure has been shown in clinical trials. Midodrine's ability to vasoconstrict without increasing heart rate suggests that it might be a useful treatment for vasovagal syncope since stimulation of the Bezold-Jarisch reflex would be less likely. For post-space flight orthostatic hypotension, midodrine may be a useful adjunctive treatment to the measures currently being used.

Original languageEnglish (US)
Pages (from-to)466-471
Number of pages6
JournalJournal of Clinical Pharmacology
Volume34
Issue number5
StatePublished - 1994
Externally publishedYes

Fingerprint

Midodrine
Orthostatic Intolerance
Vasovagal Syncope
Orthostatic Hypotension
Space Flight
Reflex
Heart Rate
Aptitude
Baroreflex
Plasma Volume
Peripheral Nervous System Diseases
Constriction
Clinical Trials
Therapeutics

ASJC Scopus subject areas

  • Pharmacology (medical)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

A comparison of postspace-flight orthostatic intolerance to vasovagal syncope and autonomic failure and the potential use of the alpha agonist midodrine for these conditions. / Piwinski, S. E.; Jankovic, J.; McElligott, M. A.

In: Journal of Clinical Pharmacology, Vol. 34, No. 5, 1994, p. 466-471.

Research output: Contribution to journalArticle

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