A comparison of cocaine vs. lidocaine with oxymetazoline for use in nasal procedures

C. P. Tarver, A. D. Noorily, C. S. Sakai

Research output: Contribution to journalArticlepeer-review

31 Scopus citations


This study compared the degree of vasoconstriction and anesthesia obtained with cocaine vs. that obtained with a mixture of lidocaine and oxymetazoline (lido/oxy) in healthy, male volunteers. Blood flow was evaluated by laser Doppler flowmetry. Anesthesia was measured with Semmes-Weinstein monofilaments, testing both sensation threshold and pain perception. A greater decrease in blood flow was seen after the administration of lido/oxy than after the administration of cocaine. Pain perception change was not significantly different between treatment groups at 10 minutes after removal of the medication-soaked pledget, but lido/oxy caused a greater decrease in pain perception than cocaine after 50 minutes. No significant difference in sensation threshold change was seen between treatment groups. Lidocaine with oxymetazoline is, therefore, believed to be an effective alternative to cocaine for nasal procedures.

Original languageEnglish (US)
Pages (from-to)653-659
Number of pages7
JournalOtolaryngology - Head and Neck Surgery
Issue number4
StatePublished - 1993

ASJC Scopus subject areas

  • Surgery
  • Otorhinolaryngology


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