A comparative analysis of liver transcriptome suggests divergent liver function among human, mouse and rat

Yao Yu, Jie Ping, Hui Chen, Longxian Jiao, Siyuan Zheng, Ze Guang Han, Pei Hao, Jian Huang

Research output: Contribution to journalArticle

26 Scopus citations

Abstract

The human liver plays a vital role in meeting the body's metabolic needs and maintaining homeostasis. To address the molecular mechanisms of liver function, we integrated multiple gene expression datasets from microarray, MPSS, SAGE and EST platforms to generate a transcriptome atlas of the normal human liver. Our results show that 17396 genes are expressed in the human liver. 238 genes were identified as liver enrichment genes, involved in the functions of immune response and metabolic processes, from the MPSS and EST datasets. A comparative analysis of liver transcriptomes was performed in humans, mice and rats with microarray datasets shows that the expression profile of homologous genes remains significantly different between mouse/rat and human, suggesting a functional variance and regulation bias of genes expressed in the livers. The integrated liver transcriptome data should provide a valuable resource for the in-depth understanding of human liver biology and liver disease.

Original languageEnglish (US)
Pages (from-to)281-289
Number of pages9
JournalGenomics
Volume96
Issue number5
DOIs
Publication statusPublished - Nov 1 2010

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Keywords

  • EST
  • Human liver
  • MPSS
  • Microarray
  • SAGE
  • Transcriptome

ASJC Scopus subject areas

  • Genetics

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