A common allele on chromosome 9 associated with coronary heart disease

Ruth McPherson; Alexander Pertsemlidis; Nihan Kavaslar; Alexandre Stewart; Robert Roberts; David R. Cox; David A. Hinds; Len A. Pennacchio; Anne Tybjaerg-Hansen; Aaron R. Folsom; Eric Boerwinkle; Helen H. Hobbs; Jonathan C. Cohen

doi:10.1126/science.1142447

A common allele on chromosome 9 associated with coronary heart disease

Ruth McPherson, Alexander Pertsemlidis, Nihan Kavaslar, Alexandre Stewart, Robert Roberts, David R. Cox, David A. Hinds, Len A. Pennacchio, Anne Tybjaerg-Hansen, Aaron R. Folsom, Eric Boerwinkle, Helen H. Hobbs, Jonathan C. Cohen

Research output: Contribution to journal › Article › peer-review

1490 Scopus citations

Abstract

Coronary heart disease (CHD) is a major cause of death in Western countries. We used genomewide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a ∼30 to 40% increased risk of CHD.

Original language	English (US)
Pages (from-to)	1488-1491
Number of pages	4
Journal	Science
Volume	316
Issue number	5830
DOIs	https://doi.org/10.1126/science.1142447
State	Published - Jun 8 2007
Externally published	Yes

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title = "A common allele on chromosome 9 associated with coronary heart disease",

abstract = "Coronary heart disease (CHD) is a major cause of death in Western countries. We used genomewide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a ∼30 to 40% increased risk of CHD.",

author = "Ruth McPherson and Alexander Pertsemlidis and Nihan Kavaslar and Alexandre Stewart and Robert Roberts and Cox, {David R.} and Hinds, {David A.} and Pennacchio, {Len A.} and Anne Tybjaerg-Hansen and Folsom, {Aaron R.} and Eric Boerwinkle and Hobbs, {Helen H.} and Cohen, {Jonathan C.}",

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doi = "10.1126/science.1142447",

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T1 - A common allele on chromosome 9 associated with coronary heart disease

AU - McPherson, Ruth

AU - Pertsemlidis, Alexander

AU - Kavaslar, Nihan

AU - Stewart, Alexandre

AU - Roberts, Robert

AU - Cox, David R.

AU - Hinds, David A.

AU - Pennacchio, Len A.

AU - Tybjaerg-Hansen, Anne

AU - Folsom, Aaron R.

AU - Boerwinkle, Eric

AU - Hobbs, Helen H.

AU - Cohen, Jonathan C.

PY - 2007/6/8

Y1 - 2007/6/8

N2 - Coronary heart disease (CHD) is a major cause of death in Western countries. We used genomewide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a ∼30 to 40% increased risk of CHD.

AB - Coronary heart disease (CHD) is a major cause of death in Western countries. We used genomewide association scanning to identify a 58-kilobase interval on chromosome 9p21 that was consistently associated with CHD in six independent samples (more than 23,000 participants) from four Caucasian populations. This interval, which is located near the CDKN2A and CDKN2B genes, contains no annotated genes and is not associated with established CHD risk factors such as plasma lipoproteins, hypertension, or diabetes. Homozygotes for the risk allele make up 20 to 25% of Caucasians and have a ∼30 to 40% increased risk of CHD.

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A common allele on chromosome 9 associated with coronary heart disease

Abstract

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