A brute force dichotomization approach to quantitative trait linkage analysis

Julia N. Bailey, Laura Almasy

    Research output: Contribution to journalArticle

    8 Scopus citations

    Abstract

    The effect of dichotomizing a continuous phenotype in linkage analysis of a simulated oligogenic trait is explored. We conclude that dichotomization does not in itself preclude the detection of loci which account for as little as 16% of the genetic variance of the disease. The effects of inclusion of known covariates and quantitative trait linkage analysis are also discussed. © 1995 Wiley‐Liss, Inc.

    Original languageEnglish (US)
    Pages (from-to)719-722
    Number of pages4
    JournalGenetic epidemiology
    Volume12
    Issue number6
    DOIs
    Publication statusPublished - 1995

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    Keywords

    • linkage analysis
    • quantitative trait
    • simulation

    ASJC Scopus subject areas

    • Epidemiology
    • Genetics(clinical)

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