A Brief Overview of Tauopathy: Causes, Consequences, and Therapeutic Strategies

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38 Scopus citations

Abstract

There are currently no disease-modifying therapies for the treatment of tauopathies, a group of progressive neurodegenerative disorders that are pathologically defined by the presence of tau protein aggregates in the brain. Current challenges for the treatment of tauopathies include the inability to diagnose early and to confidently discriminate between distinct tauopathies in patients, alongside an incomplete understanding of the cellular mechanisms involved in pathogenic tau-induced neuronal death and dysfunction. In this review, we describe current diagnostic and therapeutic strategies, known drivers of pathogenic tau formation, recent contributions to our current mechanistic understanding of how pathogenic tau induces neuronal death, and potential diagnostic and therapeutic approaches.

Original languageEnglish (US)
Pages (from-to)637-648
Number of pages12
JournalTrends in Pharmacological Sciences
Volume38
Issue number7
DOIs
StatePublished - Jul 2017

Keywords

  • Alzheimer's disease
  • metabolic syndrome
  • neurodegeneration
  • tau
  • tauopathy
  • traumatic brain injury

ASJC Scopus subject areas

  • Toxicology
  • Pharmacology

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