A biochemical study of optic nerve myelin isolated by a micromethod from different aged rats

A. S. Jacks; A. R. Richardson; M. A. Jones

doi:10.1016/0531-5565(89)90013-2

A biochemical study of optic nerve myelin isolated by a micromethod from different aged rats

A. S. Jacks, A. R. Richardson, M. A. Jones

Barshop Institute

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2′,3′-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at advanced age. Galactolipid content increased significantly at 28 months while CNPase activity decreased. The ratios of protein to galactolipid and CNPase to galactolipid changed with changing age. These data suggest that, unlike the central nervous system, specific biochemical parameters of the optic nerve change with age.

Original language	English (US)
Pages (from-to)	219-225
Number of pages	7
Journal	Experimental Gerontology
Volume	24
Issue number	3
DOIs	https://doi.org/10.1016/0531-5565(89)90013-2
State	Published - 1989

Keywords

CNPase
aging rats
lipid
myelin
nerves
protein

ASJC Scopus subject areas

Biochemistry
Aging
Molecular Biology
Genetics
Endocrinology
Cell Biology

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title = "A biochemical study of optic nerve myelin isolated by a micromethod from different aged rats",

abstract = "A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2′,3′-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at advanced age. Galactolipid content increased significantly at 28 months while CNPase activity decreased. The ratios of protein to galactolipid and CNPase to galactolipid changed with changing age. These data suggest that, unlike the central nervous system, specific biochemical parameters of the optic nerve change with age.",

keywords = "CNPase, aging rats, lipid, myelin, nerves, protein",

author = "Jacks, {A. S.} and Richardson, {A. R.} and Jones, {M. A.}",

note = "Funding Information: Acknowledgment -- The authors wish to thank Ms. Carol Wismer and Mr. Ahmad Heydari for their assistance with the optic nerve dissections. This research was supported, in part, by an ISU University Research Grant and NIH AG06819.",

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doi = "10.1016/0531-5565(89)90013-2",

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AU - Jacks, A. S.

AU - Richardson, A. R.

AU - Jones, M. A.

N1 - Funding Information: Acknowledgment -- The authors wish to thank Ms. Carol Wismer and Mr. Ahmad Heydari for their assistance with the optic nerve dissections. This research was supported, in part, by an ISU University Research Grant and NIH AG06819.

PY - 1989

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N2 - A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2′,3′-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at advanced age. Galactolipid content increased significantly at 28 months while CNPase activity decreased. The ratios of protein to galactolipid and CNPase to galactolipid changed with changing age. These data suggest that, unlike the central nervous system, specific biochemical parameters of the optic nerve change with age.

AB - A micromethod was used to study myelin from individual rat optic nerves as a function of age. Protein and galactolipid content as well as 2′,3′-cyclic nucleotide phosphohydrolase (CNPase) activity at ages 2, 4, 22, and 28 months were determined. Protein content increased significantly at 22 months and decreased at advanced age. Galactolipid content increased significantly at 28 months while CNPase activity decreased. The ratios of protein to galactolipid and CNPase to galactolipid changed with changing age. These data suggest that, unlike the central nervous system, specific biochemical parameters of the optic nerve change with age.

KW - CNPase

KW - aging rats

KW - lipid

KW - myelin

KW - nerves

KW - protein

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A biochemical study of optic nerve myelin isolated by a micromethod from different aged rats

Abstract

Keywords

ASJC Scopus subject areas

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