A bioadhesive hydrogel for sealing and treatment of corneal lacerations

Ehsan Shirzaei Sani, Clotilde Jumelle, Ahmad Kheirkhah, Yukako Taketani, Zhongmou_sun, Reza Dana, Nasim Annabi

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Abstract

Statement of Purpose: Corneal defects are one of the major corneal wounds which generally accounts for nearly 5% of blindness in the world [1]. Conventional standards of care for sealing corneal defects, including the use of cyanoacrylate glue, suturing, or other types of bioadhesives., have significant drawbacks. For instance, cyanoacrylate glue is associated with cytotoxicity, lack of transparency, rough and irregular surface, difficult handling, and lack of biointegration with the corneal stromal tissue. In addition, sutures can result in regular and irregular astigmatism, neovascularization, or infection [2]. To overcome these challenges, here we engineered a highly biocompatible and transparent composite adhesive for sealing full-thickness corneal defects using a naturally derived polymer, gelatin which is a partially hydrolyzed form of collagen with similar bioactivity combined with a synthetic biopolymer, poly(ethylene glycol) diacrylate (PEGDA).

Original languageEnglish (US)
Title of host publicationSociety for Biomaterials Annual Meeting and Exposition 2019
Subtitle of host publicationThe Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting
PublisherSociety for Biomaterials
Number of pages1
ISBN (Electronic)9781510883901
StatePublished - Jan 1 2019
Externally publishedYes
Event42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Seattle, United States
Duration: Apr 3 2019Apr 6 2019

Publication series

NameTransactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
Volume40
ISSN (Print)1526-7547

Conference

Conference42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
CountryUnited States
CitySeattle
Period4/3/194/6/19

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Biotechnology
  • Biomaterials
  • Materials Chemistry

Fingerprint Dive into the research topics of 'A bioadhesive hydrogel for sealing and treatment of corneal lacerations'. Together they form a unique fingerprint.

  • Cite this

    Sani, E. S., Jumelle, C., Kheirkhah, A., Taketani, Y., Zhongmou_sun, Dana, R., & Annabi, N. (2019). A bioadhesive hydrogel for sealing and treatment of corneal lacerations. In Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence - Transactions of the 42nd Annual Meeting (Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium; Vol. 40). Society for Biomaterials.