TY - GEN
T1 - A bioadhesive hydrogel for sealing and treatment of corneal lacerations
AU - Sani, Ehsan Shirzaei
AU - Jumelle, Clotilde
AU - Kheirkhah, Ahmad
AU - Taketani, Yukako
AU - Zhongmou_sun,
AU - Dana, Reza
AU - Annabi, Nasim
N1 - Funding Information:
Acknowledgment: Authors acknowledge the support from National Institutes of Health (NIH) (R01EB023052; R01HL140618).
Publisher Copyright:
© 2019 Omnipress - All rights reserved.
PY - 2019
Y1 - 2019
N2 - Statement of Purpose: Corneal defects are one of the major corneal wounds which generally accounts for nearly 5% of blindness in the world [1]. Conventional standards of care for sealing corneal defects, including the use of cyanoacrylate glue, suturing, or other types of bioadhesives., have significant drawbacks. For instance, cyanoacrylate glue is associated with cytotoxicity, lack of transparency, rough and irregular surface, difficult handling, and lack of biointegration with the corneal stromal tissue. In addition, sutures can result in regular and irregular astigmatism, neovascularization, or infection [2]. To overcome these challenges, here we engineered a highly biocompatible and transparent composite adhesive for sealing full-thickness corneal defects using a naturally derived polymer, gelatin which is a partially hydrolyzed form of collagen with similar bioactivity combined with a synthetic biopolymer, poly(ethylene glycol) diacrylate (PEGDA).
AB - Statement of Purpose: Corneal defects are one of the major corneal wounds which generally accounts for nearly 5% of blindness in the world [1]. Conventional standards of care for sealing corneal defects, including the use of cyanoacrylate glue, suturing, or other types of bioadhesives., have significant drawbacks. For instance, cyanoacrylate glue is associated with cytotoxicity, lack of transparency, rough and irregular surface, difficult handling, and lack of biointegration with the corneal stromal tissue. In addition, sutures can result in regular and irregular astigmatism, neovascularization, or infection [2]. To overcome these challenges, here we engineered a highly biocompatible and transparent composite adhesive for sealing full-thickness corneal defects using a naturally derived polymer, gelatin which is a partially hydrolyzed form of collagen with similar bioactivity combined with a synthetic biopolymer, poly(ethylene glycol) diacrylate (PEGDA).
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M3 - Conference contribution
AN - SCOPUS:85065427829
T3 - Transactions of the Annual Meeting of the Society for Biomaterials and the Annual International Biomaterials Symposium
SP - 958
BT - Society for Biomaterials Annual Meeting and Exposition 2019
PB - Society for Biomaterials
T2 - 42nd Society for Biomaterials Annual Meeting and Exposition 2019: The Pinnacle of Biomaterials Innovation and Excellence
Y2 - 3 April 2019 through 6 April 2019
ER -