TY - JOUR
T1 - A baboon model of bronchopulmonary dysplasia. I. Clinical features
AU - Escobedo, Marilyn B.
AU - Leonard Hilliard, J.
AU - Smith, Franklin
AU - Meredith, Keith
AU - Walsh, William
AU - Johnson, David
AU - Coalson, Jacqueline J.
AU - Kuehl, Thomas J.
AU - Null, Donald M.
AU - Robotham, James L.
N1 - Funding Information:
* Supported by Ladies Forum of the Southwest Foundation for Research and Education and presented in part at the Southern Society for Pediatric Research, January 1981. 2 To whom requests for reprints should be addressed: Department of Pediatrics, The University of Texas Health Science Center, 7703 Floyd Curl Drive, San Antonio, Tex. 78284.
PY - 1982/12
Y1 - 1982/12
N2 - Investigation in bronchopulmonary dysplasia (BPD) has been seriously hampered by the lack of a suitable animal model. The consistent development of BPD in preterm baboons (Papio cynocephalus) with hyaline membrane disease (HMD) who were treated with 95-100% inspired oxygen and supported with mechanical ventilation for more than 1 week is reported. One term (173 days) and nine preterm (134-147 days) pregnancies were delivered by cesarean section with birth weights 495-988 g. Amniotic fluid lecithin: sphingomyelin (L/S) ratios ranged from 0.47 to 1.00. The six animals with L/S ratios ≤ 0.62 developed HMD. The clinical and radiologic course was indistinguishable from HMD in preterm humans. HMD was confirmed pathologically in two animals dying acutely. One of the remaining four was supported with supplemental oxygen as needed and remains a long-term survivor of HMD. The other three were maintained in 95-100% oxygen. A clinical and radiographic picture similar to that of human BPD developed in each and was pathologically confirmed. The preterm baboon appears to be a suitable animal model for investigation of the etiology, pathophysiology, prevention, therapy, and long-term sequelae of HMD and BPD.
AB - Investigation in bronchopulmonary dysplasia (BPD) has been seriously hampered by the lack of a suitable animal model. The consistent development of BPD in preterm baboons (Papio cynocephalus) with hyaline membrane disease (HMD) who were treated with 95-100% inspired oxygen and supported with mechanical ventilation for more than 1 week is reported. One term (173 days) and nine preterm (134-147 days) pregnancies were delivered by cesarean section with birth weights 495-988 g. Amniotic fluid lecithin: sphingomyelin (L/S) ratios ranged from 0.47 to 1.00. The six animals with L/S ratios ≤ 0.62 developed HMD. The clinical and radiologic course was indistinguishable from HMD in preterm humans. HMD was confirmed pathologically in two animals dying acutely. One of the remaining four was supported with supplemental oxygen as needed and remains a long-term survivor of HMD. The other three were maintained in 95-100% oxygen. A clinical and radiographic picture similar to that of human BPD developed in each and was pathologically confirmed. The preterm baboon appears to be a suitable animal model for investigation of the etiology, pathophysiology, prevention, therapy, and long-term sequelae of HMD and BPD.
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U2 - 10.1016/0014-4800(82)90045-4
DO - 10.1016/0014-4800(82)90045-4
M3 - Article
C2 - 6759157
AN - SCOPUS:84886610744
SN - 0014-4800
VL - 37
SP - 323
EP - 334
JO - Experimental and Molecular Pathology
JF - Experimental and Molecular Pathology
IS - 3
ER -