A 6-items Questionnaire (6-QMD) captures a Mediterranean like dietary pattern and is associated with memory performance and hippocampal volume in elderly and persons at risk for Alzheimer's disease

Boris Stephan Rauchmann, Patrizia Gross, Ersin Ersoezlue, Michael Wagner, Tommaso Ballarini, Carolin Kurz, Maia Tatò, Julia Utecht, Boris Papazov, Selim Guersel, Marie Totzke, Lena Trappmann, Lena Burow, Gabriele Koller, Sophia Stöcklein, Daniel Keeser, Slawek Altenstein, Claudia Bartels, Katharina Buerger, Peter DechentLaura Dobisch, Michael Ewers, Klaus Fliessbach, Silka Dawn Freiesleben, Wenzel Glanz, Doreen Goeerss, Daria Gref, John Dylan Haynes, Daniel Janowitz, Ingo Kilimann, Okka Kimmich, Luca Kleineidam, Christoph Laske, Andrea Lohse, Franziska Maier, Coraline D. Metzger, Matthias H. Munk, Oliver Peters, Lukas Preis, Josef Priller, Sandra Roeske, Nina Roy, Carolin Sanzenbacher, Klaus Scheffler, Anja Schneider, Björn Hendrik Schott, Annika Spottke, Eike Jakob Spruth, Stefan Teipel, Debora Melo Van Lent, Jens Wiltfang, Steffen Wolfsgruber, Renat Yakupov, Emrah Düzel, Frank Jessen, Robert Perneczky

Research output: Contribution to journalArticlepeer-review

Abstract

BACKGROUND: There is evidence that adherence to Mediterranean-like diet reduces cognitive decline and brain atrophy in Alzheimer's disease (AD). However, lengthy dietary assessments, such as food frequency questionnaires (FFQs), discourage more frequent use. OBJECTIVE: Here we aimed to validate a 6-items short questionnaire for a Mediterranean-like diet (6-QMD) and explore its associations with memory performance and hippocampal atrophy in healthy elders and individuals at risk for AD. METHODS: We analyzed 938 participants (N = 234 healthy controls and N = 704 participants with an increased AD risk) from the DZNE-Longitudinal Cognitive Impairment and Dementia Study (DELCODE). The 6-QMD was validated against the Mediterranean Diet (MeDi) score and the Mediterranean-DASH Diet Intervention for Neurodegenerative Delay (MIND) score, both derived from a detailed FFQ. Furthermore, associations between the 6-QMD and memory function as well as hippocampal atrophy were evaluated using linear regressions. RESULTS: The 6-QMD was moderately associated with the FFQ-derived MeDi adherence score (ρ = 0.25, p < 0.001) and the MIND score (ρ = 0.37, p= < 0.001). Higher fish and olive oil consumption and lower meat and sausage consumption showed significant associations in a linear regression, adjusted for diagnosis, age, sex and education, with memory function (β = 0.1, p = 0.008) and bilateral hippocampal volumes (left: β = 0.15, p < 0.001); (right: β = 0.18, p < 0.001)). CONCLUSIONS: The 6-QMD is a useful and valid brief tool to assess the adherence to MeDi and MIND diets, capturing associations with memory function and brain atrophy in healthy elders and individuals at increased AD dementia risk, making it a valid alternative in settings with time constraints.

Original languageEnglish (US)
Pages (from-to)143-156
Number of pages14
JournalNutrition and Healthy Aging
Volume8
Issue number1
DOIs
StatePublished - Aug 24 2023

ASJC Scopus subject areas

  • Food Science
  • Medicine (miscellaneous)
  • Biochemistry
  • Nutrition and Dietetics

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