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• 2020

  Correlation of neurological level and sweating level of injury in persons with spinal cord injury

  Trbovich, M., Ford, A., Wu, Y., Koek, W., Wecht, J. & Kellogg, D., 2020, (Accepted/In press) In: Journal of Spinal Cord Medicine.

  Research output: Contribution to journal › Article › peer-review

  • Sweating
  • Spinal Cord Injuries
  • Sweat
  • Wounds and Injuries
  • Hot Temperature
  1 Scopus citations

• Effect of concurrent organic cation transporter blockade on norepinephrine clearance inhibiting- and antidepressant-like actions of desipramine and venlafaxine

  Primary lab of origin LCD, Sep 15 2020, In: European Journal of Pharmacology. 883, 173285.

  Research output: Contribution to journal › Article › peer-review

  • Venlafaxine Hydrochloride
  • Desipramine
  • pseudoisocyanine
  • Cations
  • Antidepressive Agents

• Factors that prevent, prompt, and delay disclosures in female victims of child sexual abuse

  Kellogg, N. D., Koek, W. & Nienow, S. M., Mar 2020, In: Child Abuse and Neglect. 101, 104360.

  Research output: Contribution to journal › Article › peer-review

  • Sexual Child Abuse
  • Disclosure
  • Sex Offenses
  • Fear
  • Moral Development
  1 Scopus citations

• Impact of tetraplegia vs. paraplegia on venoarteriolar, myogenic and maximal cutaneous vasodilation responses of the microvasculature: Implications for cardiovascular disease

  Trbovich, M., Wu, Y., Koek, W., Zhao, J. & Kellogg, D., 2020, (Accepted/In press) In: Journal of Spinal Cord Medicine.

  Research output: Contribution to journal › Article › peer-review

  • Quadriplegia
  • Paraplegia
  • Microvessels
  • Vasodilation
  • Economic Inflation

• Serotonin transporter and plasma membrane monoamine transporter are necessary for the antidepressant-like effects of ketamine in mice

  Bowman, M. A., Vitela, M., Clarke, K. M., Koek, W. & Daws, L. C., Oct 2 2020, In: International journal of molecular sciences. 21, 20, p. 1-22 22 p., 7581.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • serotonin
  • transporter
  • Cell membranes
  • Serotonin Plasma Membrane Transport Proteins
  • Membrane Transport Proteins
  1 Scopus citations
• 2019

  Comparative analysis of novel decynium-22 analogs to inhibit transport by the low-affinity, high-capacity monoamine transporters, organic cation transporters 2 and 3, and plasma membrane monoamine transporter

  Fraser-Spears, R., Krause-Heuer, A. M., Basiouny, M., Mayer, F. P., Manishimwe, R., Wyatt, N. A., Dobrowolski, J. C., Roberts, M. P., Greguric, I., Kumar, N., Koek, W., Sitte, H. H., Callaghan, P. D., Fraser, B. H. & Daws, L. C., Jan 5 2019, In: European Journal of Pharmacology. 842, p. 351-364 14 p.

  Research output: Contribution to journal › Article › peer-review

  • pseudoisocyanine
  • Organic Cation Transporter 2
  • Membrane Transport Proteins
  • Cell Membrane
  • Antidepressive Agents
  8 Scopus citations

• Efficacy of water spray for evaporative cooling in athletes with spinal cord injury

  Trbovich, M., Koek, W. & Ortega, C., Dec 1 2019, In: Spinal Cord Series and Cases. 5, 1, 51.

  Research output: Contribution to journal › Article › peer-review

  • Quadriplegia
  • Spinal Cord Injuries
  • Athletes
  • Water
  • Paraplegia
  2 Scopus citations

• Prolactin receptor expression in mouse dorsal root ganglia neuronal subtypes is sex-dependent

  Patil, M., Hovhannisyan, A. H., Wangzhou, A., Mecklenburg, J., Koek, W., Goffin, V., Grattan, D., Boehm, U., Dussor, G., Price, T. J. & Akopian, A. N., 2019, In: Journal of Neuroendocrinology. 31, 8, e12759.

  Research output: Contribution to journal › Article › peer-review

  • Prolactin Receptors
  • Spinal Ganglia
  • Sensory Receptor Cells
  • Neurons
  • Calcitonin Gene-Related Peptide Receptors
  5 Scopus citations
• 2018

  An unsuspected role for organic cation transporter 3 in the actions of amphetamine

  Mayer, F. P., Schmid, D., Owens, W. A., Gould, G. G., Apuschkin, M., Kudlacek, O., Salzer, I., Boehm, S., Chiba, P., Williams, P. H., Wu, H. H., Gether, U., Koek, W., Daws, L. C. & Sitte, H. H., Nov 1 2018, In: Neuropsychopharmacology. 43, 12, p. 2408-2417 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Amphetamine
  • Cations
  • Cocaine
  • Amphetamine-Related Disorders
  • Amphetamines
  19 Scopus citations

• A randomized control trial to establish the feasibility and safety of rapamycin treatment in an older human cohort: Immunological, physical performance, and cognitive effects

  Kraig, E., Linehan, L. A., Liang, H., Romo, T. Q., Liu, Q., Wu, Y., Benavides, A. D., Curiel, T. J., Javors, M. A., Musi, N., Chiodo, L., Koek, W., Gelfond, J. A. L. & Kellogg, D. L., May 2018, In: Experimental Gerontology. 105, p. 53-69 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Physical Functional Performance
  • Sirolimus
  • Safety
  • Erythrocyte Indices
  • Clinical laboratories
  41 Scopus citations

• Biphasic effects of selective serotonin reuptake inhibitors on anxiety: Rapid reversal of escitalopram's anxiogenic effects in the novelty-induced hypophagia test in mice?

  Koek, W., Mitchell, N. C. & Daws, L. C., 2018, In: Behavioural pharmacology. 29, 4, p. 365-369 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Citalopram
  • Serotonin Uptake Inhibitors
  • Anxiety
  • Anti-Anxiety Agents
  • Survival Analysis
  2 Scopus citations

• Constitutive plasma membrane monoamine transporter (PMAT, Slc29a4) deficiency subtly affects anxiety-like and coping behaviours

  Gilman, T. L., George, C. M., Vitela, M., Herrera-Rosales, M., Basiouny, M. S., Koek, W. & Daws, L. C., Jul 2018, In: European Journal of Neuroscience. 48, 1, p. 1706-1716 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Membrane Transport Proteins
  • Psychological Adaptation
  • Cell Membrane
  • Anxiety
  • Knockout Mice
  5 Scopus citations

• Effects of the antidepressants desipramine and fluvoxamine on latency to immobility and duration of immobility in the forced swim test in adult male C57BL/6J mice

  Koek, W., Sandoval, T. L. & Daws, L. C., Aug 1 2018, In: Behavioural pharmacology. 29, 5, p. 453-456 4 p.

  Research output: Contribution to journal › Article › peer-review

  • Fluvoxamine
  • Desipramine
  • Inbred C57BL Mouse
  • Antidepressive Agents
  • Genetic Background
  4 Scopus citations

• NLX-112, a highly selective 5-HT_1A receptor agonist: Effects on body temperature and plasma corticosterone levels in rats

  Newman-Tancredi, A., Depoortère, R., Carilla-Durand, E., Tarayre, J. P., Kleven, M., Koek, W., Bardin, L. & Varney, M. A., Feb 2018, In: Pharmacology Biochemistry and Behavior. 165, p. 56-62 7 p.

  Research output: Contribution to journal › Article › peer-review

  • befiradol
  • Serotonin 5-HT1 Receptor Agonists
  • Receptor, Serotonin, 5-HT1A
  • Rats
  • Corticosterone
  2 Scopus citations

• Pharmacokinetics of Phosphatidylethanol 16:0/20:4 in Human Blood After Alcohol Intake

  Lopez-Cruzan, M., Roache, J. D., Hill-Kapturczak, N., Karns-Wright, T. E., Dougherty, D. M., Sanchez, J. J., Koek, W. & Javors, M. A., Nov 2018, In: Alcoholism: Clinical and Experimental Research. 42, 11, p. 2094-2099 6 p.

  Research output: Contribution to journal › Article › peer-review

  • phosphatidylethanol
  • Pharmacokinetics
  • Blood
  • Alcohols
  • Alcohol Drinking
  3 Scopus citations
• 2017

  Effects of local and spinal administrations of mu-opioids on postoperative pain in aged vs adult mice

  Mecklenburg, J., Patil, M. J., Koek, W. & Akopian, A. N., 2017, In: Pain Reports. 2, 1, e584.

  Research output: Contribution to journal › Article › peer-review

  • Postoperative Pain
  • Opioid Analgesics
  • Ala(2)-MePhe(4)-Gly(5)-enkephalin
  • Nociception
  • Hypersensitivity
  2 Scopus citations

• Evaluation of the antidepressant therapeutic potential of isocyanine and pseudoisocyanine analogues of the organic cation decynium-22

  Krause-Heuer, A. M., Fraser-Spears, R., Dobrowolski, J. C., Ashford, M. E., Wyatt, N. A., Roberts, M. P., Gould, G. G., Cheah, W. C., Ng, C. K. L., Bhadbhade, M., Zhang, B., Greguric, I., Wheate, N. J., Kumar, N., Koek, W., Callaghan, P. D., Daws, L. C. & Fraser, B. H., 2017, In: European Journal of Medicinal Chemistry. 137, p. 476-487 12 p.

  Research output: Contribution to journal › Article › peer-review

  • pseudoisocyanine
  • Cations
  • Iodides
  • Antidepressive Agents
  • Serotonin Uptake Inhibitors
  6 Scopus citations

• Ontogeny of norepinephrine transporter expression and antidepressant-like response to desipramine in wild-type and serotonin transporter mutant mice

  Mitchell, N. C., Bowman, M. A., Gould, G. G., Koek, W. & Daws, L. C., Jan 2017, In: Journal of Pharmacology and Experimental Therapeutics. 360, 1, p. 84-94 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Norepinephrine Plasma Membrane Transport Proteins
  • Desipramine
  • Serotonin Plasma Membrane Transport Proteins
  • Antidepressive Agents
  • Serotonin Uptake Inhibitors
  2 Scopus citations
• 2016

  Effects of nicotine in combination with drugs described as positive allosteric nicotinic acetylcholine receptor modulators in vitro: discriminative stimulus and hypothermic effects in mice

  Moerke, M. J., de Moura, F. B., Koek, W. & McMahon, L. R., 2016, In: European Journal of Pharmacology. 786, p. 169-178 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Nicotinic Receptors
  • Drug Combinations
  • Nicotine
  • desformylflustrabromine
  • 1-(5-chloro-2,4-dimethoxyphenyl)-3-(5-methylisoxazol-3-yl)urea
  11 Scopus citations

• Morphine-induced conditioned place preference and effects of morphine pre-exposure in adolescent and adult male C57BL/6J mice

  Koek, W., Jun 1 2016, In: Psychopharmacology. 233, 11, p. 2015-2024 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Inbred C57BL Mouse
  • Morphine
  • Conditioning (Psychology)
  • Opioid-Related Disorders
  • Injections
  7 Scopus citations

• Ontogeny of SERT expression and antidepressant-like response to escitalopram in wild-type and SERT mutant mice

  Mitchell, N. C., Gould, G. G., Koek, W. & Daws, L. C., Aug 2016, In: Journal of Pharmacology and Experimental Therapeutics. 358, 2, p. 271-281 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Citalopram
  • Serotonin Plasma Membrane Transport Proteins
  • Antidepressive Agents
  • Serotonin Uptake Inhibitors
  • Genotype
  9 Scopus citations
• 2015

  Antidepressant-like effects and basal immobility depend on age and serotonin transporter genotype

  Mitchell, N. C., Koek, W. & Daws, L. C., Sep 1 2015, In: Genes, Brain and Behavior. 14, 7, p. 543-549 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Serotonin Plasma Membrane Transport Proteins
  • Antidepressive Agents
  • Genotype
  • Hindlimb Suspension
  • Desipramine
  6 Scopus citations

• Cross-tolerance to cannabinoids in morphine-tolerant rhesus monkeys

  Gerak, L. R., Zanettini, C., Koek, W. & France, C. P., Oct 1 2015, In: Psychopharmacology. 232, 19, p. 3637-3647 11 p., 4023.

  Research output: Contribution to journal › Article › peer-review

  • Cannabinoids
  • Macaca mulatta
  • Morphine
  • Opioid Analgesics
  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
  11 Scopus citations

• Drinking sucrose or saccharin enhances sensitivity of rats to quinpirole-induced yawning

  Serafine, K. M., Bentley, T. A., Kilborn, D. J., Koek, W. & France, C. P., Jul 31 2015, In: European Journal of Pharmacology. 764, p. 529-536 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Yawning
  • Quinpirole
  • Saccharin
  • Sucrose
  • Drinking
  3 Scopus citations

• Eating high fat chow, but not drinking sucrose or saccharin, enhances the development of sensitization to the locomotor effects of cocaine in adolescent female rats

  Serafine, K. M., Bentley, T. A., Koek, W. & France, C. P., Apr 1 2015, In: Behavioural pharmacology. 26, 3, p. 321-325 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Saccharin
  • Cocaine
  • Sucrose
  • Drinking
  • Eating
  12 Scopus citations

• Effects of amphetamine, morphine, and CP 55, 940 on Go/No-Go task performance in rhesus monkeys

  Koek, W., Gerak, L. R. & France, C. P., Aug 8 2015, In: Behavioural pharmacology. 26, 5, p. 481-484 4 p.

  Research output: Contribution to journal › Article › peer-review

  • 3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol
  • Amphetamine
  • Task Performance and Analysis
  • Macaca mulatta
  • Morphine
  4 Scopus citations

• Effects of consuming a diet high in fat and/or sugar on the locomotor effects of acute and repeated cocaine in male and female C57BL/6J mice

  Collins, G. T., Chen, Y., Tschumi, C., Rush, E. L., Mensah, A., Koek, W. & France, C. P., Aug 1 2015, In: Experimental and Clinical Psychopharmacology. 23, 4, p. 228-237 10 p.

  Research output: Contribution to journal › Article › peer-review

  • High Fat Diet
  • Cocaine
  • Sugars
  • Inbred C57BL Mouse
  • Sucrose
  16 Scopus citations

• NLX-112, a novel 5-HT<inf>1A</inf> receptor agonist for the treatment of l-DOPA-induced dyskinesia: Behavioral and neurochemical profile in rat

  Iderberg, H., McCreary, A. C., Varney, M. A., Kleven, M. S., Koek, W., Bardin, L., Depoortère, R., Cenci, M. A. & Newman-Tancredi, A., Sep 1 2015, In: Experimental Neurology. 271, p. 335-350 16 p.

  Research output: Contribution to journal › Article › peer-review

  • befiradol
  • Serotonin 5-HT1 Receptor Agonists
  • Receptor, Serotonin, 5-HT1A
  • Dyskinesias
  • Posture
  38 Scopus citations

• Physiological and behavioral effects of amphetamine in BACE1^-/- mice

  Paredes, R. M., Piccart, E., Navaira, E., Cruz, D., Javors, M. A., Koek, W., Beckstead, M. J. & Walss-Bass, C., Jun 1 2015, In: Genes, Brain and Behavior. 14, 5, p. 411-418 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Amphetamine
  • Dopamine
  • Autoreceptors
  • Locomotion
  • Dopaminergic Neurons
  3 Scopus citations
• 2014

  Effects of dopamine D₂-like receptor agonists in mice trained to discriminate cocaine from saline: Influence of feeding condition

  Collins, G. T., Jackson, J. A., Koek, W. & France, C. P., Apr 15 2014, In: European Journal of Pharmacology. 729, 1, p. 123-131 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Dopamine D2 Receptors
  • Cocaine
  • Dopamine Agonists
  • Dopamine D3 Receptors
  • Food
  7 Scopus citations

• Effects of repeated exposure to morphine in adolescent and adult male C57BL/6J mice: Age-dependent differences in locomotor stimulation, sensitization, and body weight loss

  Koek, W., Apr 2014, In: Psychopharmacology. 231, 8, p. 1517-1529 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Inbred C57BL Mouse
  • Morphine
  • Weight Loss
  • Body Weight
  • Locomotion
  15 Scopus citations
• 2013

  Antidepressant-like drug effects in juvenile and adolescent mice in the tail suspension test: Relationship with hippocampal serotonin and norepinephrine transporter expression and function

  Mitchell, N. C., Gould, G. G., Smolik, C. M., Koek, W. & Daws, L. C., 2013, In: Frontiers in Pharmacology. 4, OCT, p. 1-9 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Norepinephrine Plasma Membrane Transport Proteins
  • Hindlimb Suspension
  • Serotonin Plasma Membrane Transport Proteins
  • Antidepressive Agents
  • Citalopram
  14 Scopus citations

• Catecholamine/serotonin interactions. Systems thinking for brain function and disease.

  Hensler, J. G., Artigas, F., Bortolozzi, A., Daws, L. C., De Deurwaerdère, P., Milan, L., Navailles, S. & Koek, W., 2013, Advances in Pharmacology. Academic Press Inc., p. 167-197 31 p. (Advances in Pharmacology; vol. 68).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Systems Analysis
  • Brain Diseases
  • Catecholamines
  • Serotonin
  • Dopaminergic Neurons
  49 Scopus citations

• Decynium-22 enhances SSRI-induced antidepressant-like effects in mice: Uncovering novel targets to treat depression

  Horton, R. E., Apple, D. M., Owens, W. A., Baganz, N. L., Cano, S., Mitchell, N. C., Vitela, M., Gould, G. G., Koek, W. & Daws, L. C., 2013, In: Journal of Neuroscience. 33, 25, p. 10534-10543 10 p.

  Research output: Contribution to journal › Article › peer-review

  • pseudoisocyanine
  • Antidepressive Agents
  • Serotonin
  • Depression
  • Cations
  44 Scopus citations

• Discriminative stimulus effects of the GABA_B receptor-positive modulator rac-BHFF: Comparison with GABA_B receptor agonists and drugs of abuse

  Koek, W., Cheng, K. & Rice, K. C., Mar 2013, In: Journal of Pharmacology and Experimental Therapeutics. 344, 3, p. 553-560 8 p.

  Research output: Contribution to journal › Article › peer-review

  • (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one
  • Street Drugs
  • Hydroxybutyrates
  • 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol
  • Baclofen
  16 Scopus citations

• Effects of 1-(2,5-dimethoxy-4-methylphenyl)-2-aminopropane (DOM) and quipazine on heroin self-administration in rhesus monkeys

  Maguire, D. R., Li, J. X., Koek, W. & France, C. P., Jan 2013, In: Psychopharmacology. 225, 1, p. 173-185 13 p.

  Research output: Contribution to journal › Article › peer-review

  • 2,5-Dimethoxy-4-Methylamphetamine
  • Quipazine
  • Self Administration
  • Heroin
  • Macaca mulatta
  5 Scopus citations

• Revisiting serotonin reuptake inhibitors and the therapeutic potential of "uptake-2" in psychiatric disorders

  Daws, L. C., Koek, W. & Mitchell, N. C., Jan 16 2013, In: ACS Chemical Neuroscience. 4, 1, p. 16-21 6 p.

  Research output: Contribution to journal › Review article › peer-review

  • Psychiatry
  • Serotonin Uptake Inhibitors
  • Serotonin
  • Serotonin Plasma Membrane Transport Proteins
  • Antidepressive Agents
  27 Scopus citations

• Unfaithful Neurotransmitter Transporters: Focus on Biogenic Amine Reuptake and Implications for Antidepressant Efficacy

  Daws, L. C. & Koek, W., Dec 1 2013, Catecholamine Research in the 21st Century: Abstracts and Graphical Abstracts, 10th International Catecholamine Symposium, 2012. Elsevier Inc., 1 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter
• 2012

  Eating high fat chow enhances the locomotor-stimulating effects of cocaine in adolescent and adult female rats

  Baladi, M. G., Koek, W., Aumann, M., Velasco, F. & France, C. P., Aug 2012, In: Psychopharmacology. 222, 3, p. 447-457 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Cocaine
  • Eating
  • Fats
  • Dopamine
  • Cocaine-Related Disorders
  26 Scopus citations

• Effects of the GABA _B receptor-positive modulators CGP7930 and rac-BHFF in baclofen- and γ-hydroxybutyrate-discriminating pigeons

  Koek, W., France, C. P., Cheng, K. & Rice, K. C., May 1 2012, In: Journal of Pharmacology and Experimental Therapeutics. 341, 2, p. 369-376 8 p.

  Research output: Contribution to journal › Article › peer-review

  • (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one
  • 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol
  • Hydroxybutyrates
  • GABA-B Receptors
  • Baclofen
  15 Scopus citations

• GABA _B receptor-positive modulators: Brain region-dependent effects

  Hensler, J. G., Advani, T., Burke, T. F., Cheng, K., Rice, K. C. & Koek, W., Jan 2012, In: Journal of Pharmacology and Experimental Therapeutics. 340, 1, p. 19-26 8 p.

  Research output: Contribution to journal › Article › peer-review

  • (R,S)-5,7-di-tert-butyl-3-hydroxy-3-trifluoromethyl-3H-benzofuran-2-one
  • GABA-B Receptors
  • Prefrontal Cortex
  • Baclofen
  • 2,6-di-tert-butyl-4-(3-hydroxy-2,2-dimethylpropyl)phenol
  22 Scopus citations

• Interactions between Δ9-tetrahydrocannabinol and heroin: Self-administration in rhesus monkeys

  Li, J. X., Koek, W. & France, C. P., Dec 2012, In: Behavioural pharmacology. 23, 8, p. 754-761 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Dronabinol
  • Self Administration
  • Heroin
  • Macaca mulatta
  • Cannabinoid Receptor Agonists
  28 Scopus citations

• Morphine-induced motor stimulation, motor incoordination, and hypothermia in adolescent and adult mice

  Koek, W., France, C. P. & Javors, M. A., Feb 2012, In: Psychopharmacology. 219, 4, p. 1027-1037 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Ataxia
  • Hypothermia
  • Morphine
  • Locomotion
  • Age Groups
  28 Scopus citations