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• 2021

  Assessment of fatigue in hemodialysis patients: Performance of the Brief Fatigue Inventory

  Debnath, S., Rueda, R., Bansal, S., Sharma, K. & Lorenzo, C., Jan 1 2021, In: General Hospital Psychiatry. 68, p. 115-117 3 p.

  Research output: Contribution to journal › Letter › peer-review
• 2020

  A role for tubular Na⁺/H⁺ exchanger NHE3 in the natriuretic effect of the SGLT2 inhibitor empagliflozin

  Onishi, A., Fu, Y., Patel, R., Darshi, M., Crespo-Masip, M., Huang, W., Song, P., Freeman, B., Kim, Y. C., Soleimani, M., Sharma, K., Thomson, S. C. & Vallon, V., Oct 2020, In: American Journal of Physiology - Renal Physiology. 319, 4, p. F712-F728

  Research output: Contribution to journal › Article › peer-review

  • Sodium-Hydrogen Exchanger 3
  • empagliflozin
  • Sodium-Glucose Transporter 2 Inhibitors
  • Natriuretic Agents
  • Sodium-Hydrogen Exchangers
  1 Scopus citations

• A Targeted Multiomics Approach to Identify Biomarkers Associated with Rapid eGFR Decline in Type 1 Diabetes

  Limonte, C. P., Valo, E., Montemayor, D., Afshinnia, F., Ahluwalia, T. S., Costacou, T., Darshi, M., Forsblom, C., Hoofnagle, A. N., Groop, P. H., Miller, R. G., Orchard, T. J., Pennathur, S., Rossing, P., Sandholm, N., Snell-Bergeon, J. K., Ye, H., Zhang, J., Natarajan, L., De Boer, I. H. & 1 others, Sharma, K., Oct 1 2020, In: American journal of nephrology. 51, 10, p. 839-848 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Glomerular Filtration Rate
  • Type 1 Diabetes Mellitus
  • Biomarkers
  • Area Under Curve
  • Arterial Pressure

• Branched-Chain Amino Acids Depletion during Hemodialysis Is Associated with Fatigue

  Debnath, S., Lorenzo, C., Bansal, S., Morales, J., Rueda, R. O., Kasinath, B. S., Sharma, K. & O'Connor, J. C., Jul 1 2020, In: American journal of nephrology. 51, 7, p. 565-571 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Branched Chain Amino Acids
  • Renal Dialysis
  • Fatigue
  • Dialysis
  • Essential Amino Acids
  1 Scopus citations

• DESI-MSI and METASPACE indicates lipid abnormalities and altered mitochondrial membrane components in diabetic renal proximal tubules

  Zhang, G., Zhang, J., DeHoog, R. J., Pennathur, S., Anderton, C. R., Venkatachalam, M. A., Alexandrov, T., Eberlin, L. S. & Sharma, K., Jan 1 2020, In: Metabolomics. 16, 1, 11.

  Research output: Contribution to journal › Article › peer-review

  • Electrospray ionization
  • Electrospray Ionization Mass Spectrometry
  • Mass spectrometry
  • Proximal Kidney Tubule
  • Desorption
  4 Scopus citations

• Elevated lipoxygenase and cytochrome P450 products predict progression of chronic kidney disease

  Afshinnia, F., Zeng, L., Byun, J., Wernisch, S., Deo, R., Chen, J., Hamm, L., Miller, E. R., Rhee, E. P., Fischer, M. J., Sharma, K., Feldman, H. I., Michailidis, G. & Pennathur, S., Feb 1 2020, In: Nephrology Dialysis Transplantation. 35, 2, p. 303-312 10 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipoxygenase
  • Cytochrome P-450 Enzyme System
  • Chronic Renal Insufficiency
  • Disease Progression
  • Arachidonic Acid
  4 Scopus citations

• Gut microbial changes in diabetic db/db mice and recovery of microbial diversity upon pirfenidone treatment

  Singh, H., Miyamoto, S., Darshi, M., Torralba, M. G., Kwon, K., Sharma, K. & Pieper, R., Sep 2020, In: Microorganisms. 8, 9, p. 1-17 17 p., 1347.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • pirfenidone
  • Gastrointestinal Microbiome
  • acetoacetic acid
  • Firmicutes
  • 3-Hydroxybutyric Acid
  2 Scopus citations

• Identification of pathognomonic purine synthesis biomarkers by metabolomic profiling of adolescents with obesity and type 2 diabetes

  Concepcion, J., Concepcion, J., Chen, K., Saito, R., Gangoiti, J., Mendez, E., Nikita, M. E., Barshop, B. A., Barshop, B. A., Natarajan, L., Sharma, K., Kim, J. J. & Kim, J. J., Jun 2020, In: PloS one. 15, 6 June, e0234970.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Metabolomics
  • noninsulin-dependent diabetes mellitus
  • Biomarkers
  • purine
  • Medical problems

• Metabolomic Markers of Kidney Function Decline in Patients With Diabetes: Evidence From the Chronic Renal Insufficiency Cohort (CRIC) Study

  CRIC Study Investigators , Oct 2020, In: American Journal of Kidney Diseases. 76, 4, p. 511-520 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Metabolomics
  • Glomerular Filtration Rate
  • Chronic Renal Insufficiency
  • Aconitic Acid
  • Cohort Studies
  2 Scopus citations

• mGWAS: next generation genetic prediction in kidney disease

  Montemayor, D. & Sharma, K., May 1 2020, In: Nature Reviews Nephrology. 16, 5, p. 255-256 2 p.

  Research output: Contribution to journal › Article › peer-review

• Microbubble-assisted preconcentration and ultrasensitive detection of biomolecules using plasmonic chiral metamaterials

  Liu, Y., Wu, Z., Montellano, R., Sharma, K. & Zheng, Y., 2020, CLEO: Applications and Technology, CLEO_AT 2020. OSA - The Optical Society, ATh4K.5. (Optics InfoBase Conference Papers; vol. Part F181-CLEO-AT 2020).

  Research output: Chapter in Book/Report/Conference proceeding › Conference contribution

  • Plasmonic metamaterials
  • Biomolecules
  • Glucose

• Mitochondrial pyruvate and fatty acid flux modulate MICU1-dependent control of MCU activity

  Nemani, N., Dong, Z., Daw, C. C., Madaris, T. R., Ramachandran, K., Enslow, B. T., Rubannelsonkumar, C. S., Shanmughapriya, S., Mallireddigari, V., Maity, S., SinghMalla, P., Natarajanseenivasan, K., Hooper, R., Shannon, C. E., Tourtellotte, W. G., Singh, B. B., Reeves, W. B., Sharma, K., Norton, L., Srikantan, S. & 2 others, Soboloff, J. & Madesh, M., Apr 21 2020, In: Science signaling. 13, 628, eaaz6206.

  Research output: Contribution to journal › Article › peer-review

  • Citric Acid Cycle
  • Pyruvic Acid
  • Fatty Acids
  • Glycolysis
  • Fluxes
  12 Scopus citations

• Nephrology Training: Time to Revisit Integrative Physiology

  Bansal, S., Kanakia, R., Sharma, K., Tsai, S. & Prasad, A., Mar 1 2020, In: American journal of nephrology. 51, 3, p. 244-248 5 p.

  Research output: Contribution to journal › Editorial › peer-review

• Predictive Biomarkers in Nephrology Around the Corner

  Perco, P. & Sharma, K., Jan 2020, In: Kidney International Reports. 5, 1, p. 1-3 3 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Response Surface Methodology As a New Approach for Finding Optimal MALDI Matrix Spraying Parameters for Mass Spectrometry Imaging

  KPMP Consortium, Mar 4 2020, In: Journal of the American Society for Mass Spectrometry. 31, 3, p. 508-516 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Mass spectrometry
  • Matrix-Assisted Laser Desorption-Ionization Mass Spectrometry
  • Spraying
  • Mass Spectrometry
  • Imaging techniques
  3 Scopus citations

• Restoring mitochondrial superoxide levels with elamipretide (MTP-131) protects db/db mice against progression of diabetic kidney disease

  Miyamoto, S., Zhang, G., Hall, D., Oates, P. J., Maity, S., Madesh, M., Han, X. & Sharma, K., May 22 2020, In: Journal of Biological Chemistry. 295, 21, p. 7249-7260 12 p.

  Research output: Contribution to journal › Article › peer-review

  • arginyl-2,'6'-dimethyltyrosyl-lysyl-phenylalaninamide
  • Diabetic Nephropathies
  • Superoxides
  • Kidney
  • Medical problems
  1 Scopus citations

• Storage Conditions of Human Kidney Tissue Sections Affect Spatial Lipidomics Analysis Reproducibility

  Lukowski, J. K., Pamreddy, A., Velickovic, D., Zhang, G., Pasa-Tolic, L., Alexandrov, T., Sharma, K. & Anderton, C. R., Dec 2 2020, In: Journal of the American Society for Mass Spectrometry. 31, 12, p. 2538-2546 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Spatial Analysis
  • Tissue
  • Kidney
  • Temperature
  • Degradation
  1 Scopus citations
• 2019

  AMP-activated protein kinase activation ameliorates eicosanoid dysregulation in high-fat-induced kidney disease in mice

  Declèves, A. E., Mathew, A. V., Armando, A. M., Han, X., Dennis, E. A., Quehenberger, O. & Sharma, K., 2019, In: Journal of lipid research. 60, 5, p. 937-952 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Nutrition
  • AMP-Activated Protein Kinases
  • Eicosanoids
  • Kidney Diseases
  • High Fat Diet
  3 Scopus citations

• Association of Urinary Oxalate Excretion with the Risk of Chronic Kidney Disease Progression

  for the Chronic Renal Insufficiency Cohort study investigators, Apr 2019, In: JAMA internal medicine. 179, 4, p. 542-551 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Oxalates
  • Chronic Renal Insufficiency
  • Disease Progression
  • Chronic Kidney Failure
  • Glomerular Filtration Rate
  20 Scopus citations

• Blockade of MCU-Mediated Ca ²⁺ Uptake Perturbs Lipid Metabolism via PP4-Dependent AMPK Dephosphorylation

  Tomar, D., Jaña, F., Dong, Z., Quinn, W. J., Jadiya, P., Breves, S. L., Daw, C. C., Srikantan, S., Shanmughapriya, S., Nemani, N., Carvalho, E., Tripathi, A., Worth, A. M., Zhang, X., Razmpour, R., Seelam, A., Rhode, S., Mehta, A. V., Murray, M., Slade, D. & 12 others, Ramirez, S. H., Mishra, P., Gerhard, G. S., Caplan, J., Norton, L., Sharma, K., Rajan, S., Balciunas, D., Wijesinghe, D. S., Ahima, R. S., Baur, J. A. & Madesh, M., Mar 26 2019, In: Cell Reports. 26, 13, p. 3709-3725.e7

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipid Metabolism
  • protein phosphatase 4
  • Lipids
  • Oxidative Phosphorylation
  • Liver
  11 Scopus citations

• Differential network enrichment analysis reveals novel lipid pathways in chronic kidney disease

  Ma, J., Karnovsky, A., Afshinnia, F., Wigginton, J., Rader, D. J., Natarajan, L., Sharma, K., Porter, A. C., Rahman, M., He, J., Hamm, L., Shafi, T., Gipson, D., Gadegbeku, C., Feldman, H., Michailidis, G. & Pennathur, S., Sep 15 2019, In: Bioinformatics. 35, 18, p. 3441-3452 12 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipids
  • Kidney
  • Pathway
  • Triglycerides
  • Chronic Renal Insufficiency
  11 Scopus citations

• Effect of renal tubule-specific knockdown of the Na⁺/h⁺ exchanger NHE3 in akita diabetic mice

  Onishi, A., Fu, Y., Darshi, M., Crespo-Masip, M., Huang, W., Song, P., Patel, R., Kim, Y. C., Nespoux, J., Freeman, B., Soleimani, M., Thomson, S., Sharma, K. & Vallon, V., Aug 2019, In: American Journal of Physiology - Renal Physiology. 317, 2, p. F419-F434

  Research output: Contribution to journal › Article › peer-review

  • Sodium-Hydrogen Exchanger 3
  • Protein Isoforms
  • Kidney
  • Knockout Mice
  • ammonium bicarbonate
  16 Scopus citations

• Effects of dapagliflozin on urinary metabolites in people with type 2 diabetes

  Mulder, S., Heerspink, H. J. L., Darshi, M., Kim, J. J., Laverman, G. D., Sharma, K. & Pena, M. J., Nov 1 2019, In: Diabetes, Obesity and Metabolism. 21, 11, p. 2422-2428 7 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • 2-(3-(4-ethoxybenzyl)-4-chlorophenyl)-6-hydroxymethyltetrahydro-2H-pyran-3,4,5-triol
  • Type 2 Diabetes Mellitus
  • Sodium-Glucose Transporter 2 Inhibitors
  • Symporters
  • Placebos
  8 Scopus citations

• Gene Expression Studies and Targeted Metabolomics Reveal Disturbed Serine, Methionine, and Tyrosine Metabolism in Early Hypertensive Nephrosclerosis

  Øvrehus, M. A., Bruheim, P., Ju, W., Zelnick, L. R., Langlo, K. A., Sharma, K., de Boer, I. H. & Hallan, S. I., Feb 2019, In: Kidney International Reports. 4, 2, p. 321-333 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Nephrosclerosis
  • Metabolomics
  • Methionine
  • Serine
  • Tyrosine
  6 Scopus citations

• Global Health Training Opportunities in North American Nephrology Fellowships

  International Society of Nephrology North American and Caribbean Regional Board, Jul 2019, In: Kidney International Reports. 4, 7, p. 904-907 4 p.

  Research output: Contribution to journal › Editorial › peer-review

  Open Access

• Increased lipogenesis and impaired B-oxidation predict type 2 diabetic kidney disease progression in American Indians

  Afshinnia, F., Nair, V., Lin, J., Rajendiran, T. M., Soni, T., Byun, J., Sharma, K., Fort, P. E., Gardner, T. W., Looker, H. C., Nelson, R. G., Brosius, F. C., Feldman, E. L., Michailidis, G., Kretzler, M. & Pennathur, S., Nov 1 2019, In: JCI Insight. 4, 21, e130317.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Lipogenesis
  • North American Indians
  • Diabetic Nephropathies
  • Disease Progression
  • Glomerular Filtration Rate
  6 Scopus citations

• Management of calciphylaxis in a burn center: A case series and review of the literature

  Dado, D. N., Huang, B., Foster, D. V., Nielsen, J. S., Gurney, J. M., Morrow, B. D., Sharma, K., Chung, K. K. & Ainsworth, C. R., Feb 2019, In: Burns. 45, 1, p. 241-246 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Calciphylaxis
  • Burn Units
  • Critical Care
  • Wounds and Injuries
  • Skin
  2 Scopus citations

• Molecular imaging of the glomerulus via mesangial cell uptake of radiolabeled tilmanocept

  Qin, Z., Hoh, C. K., Olson, E. S., Jahromi, A. H., Hall, D. J., Barback, C. V., You, Y. H., Yanagita, M., Sharma, K. & Vera, D. R., 2019, In: Journal of Nuclear Medicine. 60, 9, p. 1325-1332 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Mesangial Cells
  • Molecular Imaging
  • IRDye800
  • Kidney
  • technetium-diethylenetriaminepentaacetic acid-mannosyl-dextran
  4 Scopus citations

• Myofibroblasts acquire retinoic acid–producing ability during fibroblast-to-myofibroblast transition following kidney injury

  Nakamura, J., Sato, Y., Kitai, Y., Wajima, S., Yamamoto, S., Oguchi, A., Yamada, R., Kaneko, K., Kondo, M., Uchino, E., Tsuchida, J., Hirano, K., Sharma, K., Kohno, K. & Yanagita, M., Mar 2019, In: Kidney international. 95, 3, p. 526-539 14 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Myofibroblasts
  • Fibroblasts
  • Retinaldehyde
  • Kidney
  • Wounds and Injuries
  12 Scopus citations

• Role of mitochondria in the regulation of kidney function and metabolism in type 2 diabetes

  Han, X., Shi, Y., Diamond-Stanic, M. & Sharma, K., Jan 1 2019, Mitochondria in Obesity and Type 2 Diabetes: Comprehensive Review on Mitochondrial Functioning and Involvement in Metabolic Diseases. Elsevier, p. 287-300 14 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Mitochondria
  • noninsulin-dependent diabetes mellitus
  • Metabolism
  • renal function
  • Medical problems

• Sex-related disparities in CKD progression

  CRIC Investigators, Jan 2019, In: Journal of the American Society of Nephrology. 30, 1, p. 137-146 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Chronic Kidney Failure
  • Sex Characteristics
  • Biological Factors
  • Hispanic Americans
  • Social Adjustment
  32 Scopus citations

• The NASA twins study: A multidimensional analysis of a year-long human spaceflight

  Garrett-Bakelman, F. E., Darshi, M., Green, S. J., Gur, R. C., Lin, L., Macias, B. R., McKenna, M. J., Meydan, C., Mishra, T., Nasrini, J., Piening, B. D., Rizzardi, L. F., Sharma, K., Siamwala, J. H., Taylor, L., Vitaterna, M. H., Afkarian, M., Afshinnekoo, E., Ahadi, S., Ambati, A. & 62 others, Arya, M., Bezdan, D., Callahan, C. M., Chen, S., Choi, A. M. K., Chlipala, G. E., Contrepois, K., Covington, M., Crucian, B. E., De Vivo, I., Dinges, D. F., Ebert, D. J., Feinberg, J. I., Gandara, J. A., George, K. A., Goutsias, J., Grills, G. S., Hargens, A. R., Heer, M., Hillary, R. P., Hoofnagle, A. N., Hook, V. Y. H., Jenkinson, G., Jiang, P., Keshavarzian, A., Laurie, S. S., Lee-McMullen, B., Lumpkins, S. B., MacKay, M., Maienschein-Cline, M. G., Melnick, A. M., Moore, T. M., Nakahira, K., Patel, H. H., Pietrzyk, R., Rao, V., Saito, R., Salins, D. N., Schilling, J. M., Sears, D. D., Sheridan, C. K., Stenger, M. B., Tryggvadottir, R., Urban, A. E., Vaisar, T., Van Espen, B., Zhang, J., Ziegler, M. G., Zwart, S. R., Charles, J. B., Kundrot, C. E., Scott, G. B. I., Bailey, S. M., Basner, M., Feinberg, A. P., Lee, S. M. C., Mason, C. E., Mignot, E., Rana, B. K., Smith, S. M., Snyder, M. P. & Turek, F. W., 2019, In: Science. 364, 6436, eaau8650.

  Research output: Contribution to journal › Article › peer-review

  • United States National Aeronautics and Space Administration
  • Space Flight
  • Twin Studies
  • Telomere
  • Astronauts
  156 Scopus citations
• 2018

  A new drug combination significantly reduces kidney tumor progression in kidney mouse model

  Liang, S., Cuellar, T., Nowacki, M., Nayak, B. K., Dong, L., Li, B., Sharma, K. & Habib, S. L., Aug 31 2018, In: Oncotarget. 9, 68, p. 32900-32916 17 p.

  Research output: Contribution to journal › Article › peer-review

  • Drug Combinations
  • Angiomyolipoma
  • Tuberous Sclerosis
  • Kidney
  • acadesine

• Efficacy of a novel inhibitor of vascular adhesion protein-1 in reducing albuminuria in patients with diabetic kidney disease (ALBUM): a randomised, placebo-controlled, phase 2 trial

  de Zeeuw, D., Renfurm, R. W., Bakris, G., Rossing, P., Perkovic, V., Hou, F. F., Nangaku, M., Sharma, K., Heerspink, H. J. L., Garcia-Hernandez, A. & Larsson, T. E., Dec 2018, In: The Lancet Diabetes and Endocrinology. 6, 12, p. 925-933 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Albuminuria
  • Diabetic Nephropathies
  • Placebos
  • Blood Vessels
  • Albumins
  12 Scopus citations

• Introduction: Systems Biology of Kidney Disease

  Sharma, K., Susztak, K. & Pennathur, S., Mar 2018, In: Seminars in nephrology. 38, 2, p. 99-100 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Scopus citations

• The Warburg Effect in Diabetic Kidney Disease

  Zhang, G., Darshi, M. & Sharma, K., Mar 2018, In: Seminars in nephrology. 38, 2, p. 111-120 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Diabetic Nephropathies
  • thyroid hormone-binding proteins
  • Fumarates
  • Sphingomyelins
  • Systems Biology
  27 Scopus citations

• Toward individual glomerular phenotyping: advent of precision medicine in kidney biopsies

  Sharma, K. & Paša-Tolić, L., Jun 2018, In: Kidney international. 93, 6, p. 1265-1267 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • lysosomal proteins
  • Nephrology
  • Precision Medicine
  • Proteome
  • Biopsy

• Urine metabolites are associated with glomerular lesions in type 2 diabetes

  Saulnier, P. J., Darshi, M., Wheelock, K. M., Looker, H. C., Fufaa, G. D., Knowler, W. C., Weil, E. J., Tanamas, S. K., Lemley, K. V., Saito, R., Natarajan, L., Nelson, R. G. & Sharma, K., Jun 1 2018, In: Metabolomics. 14, 6, 84.

  Research output: Contribution to journal › Article › peer-review

  • Metabolites
  • Medical problems
  • Biopsy
  • Type 2 Diabetes Mellitus
  • Urine
  6 Scopus citations

• Uromodulin mRNA from Urinary Extracellular Vesicles Correlate to Kidney Function Decline in Type 2 Diabetes Mellitus

  Yamamoto, C. M., Murakami, T., Oakes, M. L., Mitsuhashi, M., Kelly, C., Henry, R. R. & Sharma, K., Jun 1 2018, In: American Journal of Nephrology. 47, 5, p. 283-291 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Uromodulin
  • Extracellular Vesicles
  • Diabetic Nephropathies
  • Type 2 Diabetes Mellitus
  • Messenger RNA
  12 Scopus citations
• 2017

  Acid Load and Phosphorus Homeostasis in CKD

  Chronic Renal Insufficiency Cohort (CRIC) Study Investigators & Chronic Renal Insufficiency Cohort (CRIC) Study Investigators, Oct 2017, In: American Journal of Kidney Diseases. 70, 4, p. 541-550 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Phosphorus Acids
  • Chronic Renal Insufficiency
  • Acids
  • Homeostasis
  • Phosphorus
  11 Scopus citations

• AICAR ameliorates high-fat diet-associated pathophysiology in mouse and ex vivo models, independent of adiponectin

  Börgeson, E., Wallenius, V., Syed, G. H., Darshi, M., Lantero Rodriguez, J., Biörserud, C., Ragnmark Ek, M., Björklund, P., Quiding-Järbrink, M., Fändriks, L., Godson, C. & Sharma, K., Apr 1 2017, In: Diabetologia. 60, 4, p. 729-739 11 p.

  Research output: Contribution to journal › Article › peer-review

  • AICA ribonucleotide
  • Adiponectin
  • High Fat Diet
  • Adipose Tissue
  • Fats
  11 Scopus citations

• A metabolite-GWAS (mGWAS) approach to unveil chronic kidney disease progression

  Zhang, G., Saito, R. & Sharma, K., Jun 2017, In: Kidney international. 91, 6, p. 1274-1276 3 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  • Genome-Wide Association Study
  • Chronic Renal Insufficiency
  • Disease Progression
  • omega-N-Methylarginine
  • Metabolomics
  3 Scopus citations

• Kidney disease and obesity: Epidemiology, mechanisms and treatment

  Câmara, N. O. S., Iseki, K., Kramer, H., Liu, Z. H. & Sharma, K., Mar 1 2017, In: Nature Reviews Nephrology. 13, 3, p. 181-190 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Kidney Diseases
  • Epidemiology
  • Obesity
  • Research Personnel
  • Nephrology
  44 Scopus citations

• Linagliptin and its effects on hyperglycaemia and albuminuria in patients with type 2 diabetes and renal dysfunction: the randomized MARLINA-T2D trial

  Groop, P. H., Cooper, M. E., Perkovic, V., Hocher, B., Kanasaki, K., Haneda, M., Schernthaner, G., Sharma, K., Stanton, R. C., Toto, R., Cescutti, J., Gordat, M., Meinicke, T., Koitka-Weber, A., Thiemann, S. & von Eynatten, M., Nov 2017, In: Diabetes, Obesity and Metabolism. 19, 11, p. 1610-1619 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Linagliptin
  • Albuminuria
  • Hyperglycemia
  • Type 2 Diabetes Mellitus
  • Placebos
  70 Scopus citations

• Metabolomics and Gene Expression Analysis Reveal Down-regulation of the Citric Acid (TCA) Cycle in Non-diabetic CKD Patients

  Hallan, S., Afkarian, M., Zelnick, L. R., Kestenbaum, B., Sharma, S., Saito, R., Darshi, M., Barding, G., Raftery, D., Ju, W., Kretzler, M., Sharma, K. & de Boer, I. H., Dec 2017, In: EBioMedicine. 26, p. 68-77 10 p.

  Research output: Contribution to journal › Article › peer-review

  • Citric Acid Cycle
  • Metabolomics
  • Metabolites
  • Gene expression
  • Chronic Renal Insufficiency
  41 Scopus citations

• Mitochondrial dysfunction in the diabetic kidney

  Sharma, K., May 1 2017, Advances in Experimental Medicine and Biology. Springer New York LLC, p. 553-562 10 p. (Advances in Experimental Medicine and Biology; vol. 982).

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Mitochondria
  • Diabetic Nephropathies
  • Diabetes Complications
  • Superoxides
  • Metabolomics
  15 Scopus citations

• Myeloperoxidase Activity and Oxidized Amino Acids as Biomarkers in Chronic Kidney Disease and Coronary Artery Disease

  Sharma, K., Jul 1 2017, In: American journal of nephrology. 46, 1, p. 71-72 2 p.

  Research output: Contribution to journal › Editorial › peer-review
  2 Scopus citations

• The effects of atrasentan on urinary metabolites in patients with type 2 diabetes and nephropathy

  Pena, M. J., de Zeeuw, D., Andress, D., Brennan, J. J., Correa-Rotter, R., Coll, B., Kohan, D. E., Makino, H., Perkovic, V., Remuzzi, G., Tobe, S. W., Toto, R., Parving, H. H., Sharma, S., Corringham, T., Sharma, K. & Heerspink, H. J. L., May 2017, In: Diabetes, Obesity and Metabolism. 19, 5, p. 749-753 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Atrasentan
  • Type 2 Diabetes Mellitus
  • Placebos
  • Gas Chromatography-Mass Spectrometry
  • Albuminuria
  10 Scopus citations
• 2016

  Aging increases the susceptibility of hepatic inflammation, liver fibrosis and aging in response to high-fat diet in mice

  Kim, I. H., Xu, J., Liu, X., Koyama, Y., Ma, H. Y., Diggle, K., You, Y. H., Schilling, J. M., Jeste, D., Sharma, K., Brenner, D. A. & Kisseleva, T., Aug 1 2016, In: AGE. 38, 4, p. 291-302 12 p.

  Research output: Contribution to journal › Article › peer-review

  • High Fat Diet
  • Liver Cirrhosis
  • Inflammation
  • Liver
  • Fibrosis
  30 Scopus citations

• Challenging the dogma of mitochondrial reactive oxygen species overproduction in diabetic kidney disease

  Coughlan, M. T. & Sharma, K., Aug 1 2016, In: Kidney international. 90, 2, p. 272-279 8 p.

  Research output: Contribution to journal › Review article › peer-review

  • Reactive Oxygen Species
  • Diabetic Nephropathies
  • Diabetes Complications
  • Mitochondria
  • Organelle Biogenesis
  41 Scopus citations