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• 2020

  The gut microbiome distinguishes mortality in trauma patients upon admission to the emergency department

  Burmeister, D. M., Johnson, T. R., Lai, Z., Scroggins, S. R., Derosa, M., Jonas, R. B., Zhu, C., Scherer, E., Stewart, R. M., Schwacha, M. G., Jenkins, D. H., Eastridge, B. J. & Nicholson, S. E., May 1 2020, In: Journal of Trauma and Acute Care Surgery. 88, 5, p. 579-587 9 p.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Patient Admission
  • Gastrointestinal Microbiome
  • Hospital Emergency Service
  • Mortality
  • Wounds and Injuries
  2 Scopus citations
• 2019

  A prospective study in severely injured patients reveals an altered gut microbiome is associated with transfusion volume

  Nicholson, S. E., Burmeister, D. M., Johnson, T. R., Zou, Y., Lai, Z., Scroggins, S., Derosa, M., Jonas, R. B., Merrill, D. R., Zhu, C., Newton, L. M., Stewart, R. M., Schwacha, M. G., Jenkins, D. H. & Eastridge, B. J., Apr 1 2019, In: Journal of Trauma and Acute Care Surgery. 86, 4, p. 573-581 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gastrointestinal Microbiome
  • Prospective Studies
  • Wounds and Injuries
  • Healthy Volunteers
  • Proteobacteria
  5 Scopus citations

• Burn injury is associated with an infiltration of the wound site with myeloid-derived suppressor cells

  Schwacha, M. G., Scroggins, S. R., Montgomery, R. K., Nicholson, S. E. & Cap, A. P., Apr 2019, In: Cellular Immunology. 338, p. 21-26 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Myeloid-Derived Suppressor Cells
  • Wounds and Injuries
  • Skin
  3 Scopus citations

• Moderate Traumatic Brain Injury Alters the Gastrointestinal Microbiome in a Time-Dependent Manner

  Nicholson, S. E., Watts, L. T., Burmeister, D. M., Merrill, D., Scroggins, S., Zou, Y., Lai, Z., Grandhi, R., Lewis, A. M., Newton, L. M., Eastridge, B. J. & Schwacha, M. G., Aug 1 2019, In: Shock. 52, 2, p. 240-248 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Gastrointestinal Microbiome
  • Traumatic Brain Injury
  • Microbiota
  • Craniotomy
  • Bacteriophages
  24 Scopus citations
• 2018

  Compensatory reserve index: Performance of a novel monitoring technology to identify the bleeding trauma patient

  Johnson, M. C., Alarhayem, A., Convertino, V., Carter, R., Chung, K., Stewart, R., Myers, J., Dent, D., Liao, L., Cestero, R., Nicholson, S., Muir, M., Schwacha, M., Wampler, D., DeRosa, M. & Eastridge, B. J., Mar 1 2018, In: Shock. 49, 3, p. 295-300 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Technology
  • Hemorrhage
  • Blood Pressure
  • Wounds and Injuries
  • Trauma Centers
  12 Scopus citations

• Immunopathological response to severe injury: Platelet activation and the Th-17 immune response

  Morris, R. S., Schaffer, B. S., Lundy, J. B., Pidcoke, H. F., Chung, K. K., Darlington, D. N., Cap, A. P. & Schwacha, M. G., Jan 1 2018, In: Blood Coagulation and Fibrinolysis. 29, 1, p. 48-54 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Platelet Activation
  • Wounds and Injuries
  • fibrin fragment D
  • Blood Platelets
  • Healthy Volunteers
  5 Scopus citations

• Polytrauma independent of therapeutic intervention alters the gastrointestinal microbiome

  Nicholson, S. E., Merrill, D., Zhu, C., Burmeister, D. M., Zou, Y., Lai, Z., Darlington, D. N., Lewis, A. M., Newton, L., Scroggins, S., Eastridge, B. J. & Schwacha, M. G., Oct 1 2018, In: American Journal of Surgery. 216, 4, p. 699-705 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Multiple Trauma
  • Gastrointestinal Microbiome
  • Wounds and Injuries
  • Bacteroidaceae
  • Crush Injuries
  5 Scopus citations
• 2017

  Damage-associated molecular patterns (DAMPs) released after burn are associated with inflammation and monocyte activation

  Rani, M., Nicholson, S. E., Zhang, Q. & Schwacha, M. G., Mar 1 2017, In: Burns. 43, 2, p. 297-303 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Toll-Like Receptors
  • HMGB1 Protein
  • Monocytes
  • Cytochromes
  • Hyaluronic Acid
  32 Scopus citations

• The composition of T-cell subsets are altered in the burn wound early after injury

  Rani, M. & Schwacha, M. G., Jun 2017, In: PloS one. 12, 6, e0179015.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • T-Lymphocyte Subsets
  • T-lymphocytes
  • Chemical analysis
  • T-Lymphocytes
  7 Scopus citations

• Traumatic Hemothorax Blood Contains Elevated Levels of Microparticles that are Prothrombotic but Inhibit Platelet Aggregation

  Mitchell, T. A., Herzig, M. C., Fedyk, C. G., Salhanick, M. A., Henderson, A. T., Parida, B. K., Prat, N. J., Dent, D. L., Schwacha, M. G. & Cap, A. P., Jun 1 2017, In: Shock. 47, 6, p. 680-687 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Hemothorax
  • Platelet Aggregation
  • Thromboplastin
  • von Willebrand Factor
  • Blood Platelets
  7 Scopus citations
• 2016

  Dermal γδ T-cells can be activated by mitochondrial damage-associated molecular patterns

  Schwacha, M. G., Rani, M., Nicholson, S. E., Lewis, A. M., Holloway, T. L., Sordo, S. & Cap, A. P., Jul 2016, In: PloS one. 11, 7, e0158993.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • T-lymphocytes
  • T-Lymphocytes
  • Skin
  • Intraepithelial Lymphocytes
  9 Scopus citations

• Shed pleural blood from traumatic hemothorax contains elevated levels of pro-inflammatory cytokines

  Salhanick, M. A., Sams, V. G., Pidcoke, H. F., Fedyk, C. G., Scherer, M. R., Dubick, M. A., Dent, D. L., Cap, A. P. & Schwacha, M. G., Aug 1 2016, In: Shock. 46, 2, p. 144-148 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Hemothorax
  • Cytokines
  • Autologous Blood Transfusions
  • Wounds and Injuries
  • Healthy Volunteers
  7 Scopus citations

• Toll-like receptor responses are suppressed in trauma ICU patients

  Holloway, T. L., Nicholson, S. E., Rani, M., Cap, A. P. & Schwacha, M. G., Nov 1 2016, In: Journal of Surgical Research. 206, 1, p. 139-145 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Toll-Like Receptors
  • Intensive Care Units
  • Healthy Volunteers
  • Wounds and Injuries
  • Zymosan
  2 Scopus citations

• Tranexamic Acid Attenuates the Loss of Lung Barrier Function in a Rat Model of Polytrauma and Hemorrhage with Resuscitation

  Wu, X., Dubick, M. A., Schwacha, M. G., Cap, A. P. & Darlington, D. N., Sep 19 2016, (Accepted/In press) In: Shock.

  Research output: Contribution to journal › Article › peer-review

  • Tranexamic Acid
  • Multiple Trauma
  • Resuscitation
  • Hemorrhage
  • Lung
  15 Scopus citations

• Trauma-Related Acute Lung Injury Develops Rapidly Irrespective of Resuscitation Strategy in the Rat

  Wu, X., Schwacha, M. G., Dubick, M. A., Cap, A. P. & Darlington, D. N., May 11 2016, (Accepted/In press) In: Shock.

  Research output: Contribution to journal › Article › peer-review

  • Acute Lung Injury
  • Resuscitation
  • Ringer's Lactate
  • Multiple Trauma
  • Wounds and Injuries
  8 Scopus citations
• 2015

  Activated skin γδ T-cells regulate T-cell infiltration of the wound site after burn

  Rani, M., Zhang, Q., Scherer, M. R., Cap, A. P. & Schwacha, M. G., Feb 8 2015, In: Innate Immunity. 21, 2, p. 140-150 11 p.

  Research output: Contribution to journal › Article › peer-review

  • T-Lymphocytes
  • Skin
  • Wounds and Injuries
  • T-Cell Antigen Receptor
  • Population
  14 Scopus citations

• A rat model of concurrent combined injuries (polytrauma)

  Akscyn, R. M., Franklin, J. L., Gavrikova, T. A., Schwacha, M. G. & Messina, J. L., Nov 30 2015, In: International Journal of Clinical and Experimental Medicine. 8, 11, p. 20097-20110 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Rats
  • Multiple Trauma
  • Wounds and Injuries
  • Military operations
  • Needles
  3 Scopus citations

• Gamma Delta T Cells Regulate Inflammatory Cell Infiltration of the Lung after Trauma-Hemorrhage

  Rani, M., Zhang, Q., Oppeltz, R. F. & Schwacha, M. G., Jun 4 2015, In: Shock. 43, 6, p. 589-597 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Intraepithelial Lymphocytes
  • Hemorrhage
  • T-Lymphocytes
  • Lung
  • Wounds and Injuries
  9 Scopus citations

• The association between the Th-17 immune response and pulmonary complications in a trauma ICU population

  Holloway, T. L., Rani, M., Cap, A. P., Stewart, R. M. & Schwacha, M. G., Dec 1 2015, In: Cytokine. 76, 2, p. 328-333 6 p.

  Research output: Contribution to journal › Article › peer-review

  • Intensive care units
  • Th17 Cells
  • Intensive Care Units
  • Blood
  • Fluids
  7 Scopus citations

• Trauma-induced coagulopathy is associated with a complex inflammatory response in the rat

  Darlington, D. N., Gonzales, M. D., Craig, T., Dubick, M. A., Cap, A. P. & Schwacha, M. G., Aug 1 2015, In: Shock. 44, p. 129-137 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Multiple Trauma
  • Cytokines
  • Interleukin-1
  • Wounds and Injuries
  • Partial Thromboplastin Time
  11 Scopus citations
• 2014

  An experimental model of hemothorax autotransfusion: Impact on coagulation

  Harrison, H. B., Smith, W. Z., Salhanick, M. A., Higgins, R. A., Ortiz, A., Olson, J. D., Schwacha, M. G., Harrison, C. R., Aydelotte, J. D., Stewart, R. M. & Dent, D. L., Dec 1 2014, In: American journal of surgery. 208, 6, p. 1078-1082 5 p.

  Research output: Contribution to journal › Article › peer-review

  • Autologous Blood Transfusions
  • Hemothorax
  • Theoretical Models
  • Partial Thromboplastin Time
  • Wounds and Injuries
  5 Scopus citations

• Burn wound γδ T-cells support a Th2 and Th17 immune response

  Rani, M., Zhang, Q. & Schwacha, M. G., 2014, In: Journal of Burn Care and Research. 35, 1, p. 46-53 8 p.

  Research output: Contribution to journal › Article › peer-review

  • T-Lymphocytes
  • Interferons
  • Interleukin-17
  • Cytokines
  • Wounds and Injuries
  16 Scopus citations

• Gamma delta t cells regulate wound myeloid CELL activity after burn

  Rani, M., Zhang, Q. & Schwacha, M. G., Aug 2014, In: Shock. 42, 2, p. 133-141 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Somatostatin-Secreting Cells
  • Myeloid Cells
  • Macrophage Inflammatory Proteins
  • Wounds and Injuries
  • Skin
  15 Scopus citations

• Mitochondrial damage-associated molecular patterns activate γδ T-cells

  Schwacha, M. G., Rani, M., Zhang, Q., Nunez-Cantu, O. & Cap, A. P., Apr 2014, In: Innate Immunity. 20, 3, p. 261-268 8 p.

  Research output: Contribution to journal › Article › peer-review

  • T-Lymphocytes
  • Intraepithelial Lymphocytes
  • Mitochondria
  • Wounds and Injuries
  • Sonication
  19 Scopus citations
• 2013

  Acute coagulopathy of trauma in the rat

  Darlington, D. N., Craig, T., Gonzales, M. D., Schwacha, M. G., Cap, A. P. & Dubick, M. A., May 1 2013, In: Shock. 39, 5, p. 440-446 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Platelet Count
  • Partial Thromboplastin Time
  • Prothrombin Time
  • Multiple Trauma
  • Wounds and Injuries
  40 Scopus citations

• A small amount can make a difference: A prospective human study of the paradoxical coagulation characteristics of hemothorax

  Smith, W. Z., Harrison, H. B., Salhanick, M. A., Higgins, R. A., Ortiz, A., Olson, J. D., Schwacha, M. G., Harrison, C. R., Aydelotte, J. D., Stewart, R. M. & Dent, D. L., Dec 1 2013, In: American Journal of Surgery. 206, 6, p. 904-910 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Hemothorax
  • Prospective Studies
  • Thoracostomy
  • Autologous Blood Transfusions
  • Thoracic Injuries
  7 Scopus citations
• 2012

  Aging and the pathogenic response to burn

  Rani, M. & Schwacha, M. G., 2012, In: Aging and Disease. 3, 2, p. 171-180 10 p.

  Research output: Contribution to journal › Review article › peer-review

  • Elderly
  • Immunosenescence
  • Burns
  • Population
  • Morbidity
  29 Scopus citations

• Burn enhances toll-like receptor induced responses by circulating leukocytes

  Schwacha, M. G., Zhang, Q., Rani, M., Craig, T. & Oppeltz, R. F., Apr 26 2012, In: International Journal of Clinical and Experimental Medicine. 5, 2, p. 136-144 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Toll-Like Receptors
  • Chemical activation
  • Leukocytes
  • Blood
  • Interleukin-10
  13 Scopus citations

• Differential expression of the immunoinflammatory response in trauma patients: Burn vs. non-burn

  Mace, J. E., Park, M. S., Mora, A. G., Chung, K. K., Martini, W., White, C. E., Holcomb, J. B., Merrill, G. A., Dubick, M. A., Wolf, S. E., Wade, C. E. & Schwacha, M. G., Jun 1 2012, In: Burns. 38, 4, p. 599-606 8 p.

  Research output: Contribution to journal › Article › peer-review

  • Multiple Organ Failure
  • Wounds and Injuries
  • Interleukin-8
  • Interleukin-6
  • Cytokines
  27 Scopus citations

• Gamma delta (γδ) T-cells are critical in the up-regulation of inducible nitric oxide synthase at the burn wound site

  Oppeltz, R. F., Rani, M., Zhang, Q. & Schwacha, M. G., Nov 2012, In: Cytokine. 60, 2, p. 528-534 7 p.

  Research output: Contribution to journal › Article › peer-review

  • T-cells
  • Intraepithelial Lymphocytes
  • Nitric Oxide Synthase Type II
  • Up-Regulation
  • Wounds and Injuries
  13 Scopus citations