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• 2020

  B cell endosomal RAB7 promotes TRAF6 K63 polyubiquitination and NF-κB activation for antibody class-switching

  Yan, H., Fernandez, M., Wang, J., Wu, S., Wang, R., Lou, Z., Moroney, J. B., Rivera, C. E., Taylor, J. R., Gan, H., Zan, H., Kolvaskyy, D., Liu, D., Casali, P. & Xu, Z., Mar 1 2020, In: Journal of Immunology. 204, 5, p. 1146-1157 12 p.

  Research output: Contribution to journal › Article › peer-review

  • TNF Receptor-Associated Factor 6
  • Immunoglobulin Class Switching
  • Immunoglobulin Isotypes
  • B-Lymphocytes
  • AICDA (activation-induced cytidine deaminase)
  1 Scopus citations

• B cell-intrinsic epigenetic modulation of antibody responses by dietary fiber-derived short-chain fatty acids

  Sanchez, H. N., Moroney, J. B., Gan, H., Shen, T., Im, J. L., Li, T., Taylor, J. R., Zan, H. & Casali, P., Dec 1 2020, In: Nature communications. 11, 1, 60.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Dietary Fiber
  • fatty acids
  • Volatile Fatty Acids
  • antibodies
  • Cells
  24 Scopus citations

• B cell Sirt1 deacetylates histone and non-histone proteins for epigenetic modulation of AID expression and the antibody response

  Gan, H., Shen, T., Chupp, D. P., Taylor, J. R., Sanchez, H. N., Li, X., Xu, Z., Zan, H. & Casali, P., Apr 1 2020, In: Science Advances. 6, 14, eaay2793.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • AICDA (activation-induced cytidine deaminase)
  • Sirtuin 1
  • Histones
  • Antibody Formation
  • Epigenomics
  6 Scopus citations

• Epigenetics of the antibody and autoantibody response

  Moroney, J. B., Chupp, D. P., Xu, Z., Zan, H. & Casali, P., Dec 2020, In: Current Opinion in Immunology. 67, p. 75-86 12 p.

  Research output: Contribution to journal › Review article › peer-review

  Open Access

  • Plasma Cells
  • Autoantibodies
  • Antibody Formation
  • Epigenomics
  • Cell Differentiation

• Erratum: B cell endosomal Rab7 promotes TRAF6 K63 polyubiquitination and NF- B activation for antibody class-switching (Journal of Immunology (2020) 204 (1146-1157) DOI: 10.4049/jimmunol.1901170)

  Yan, H., Fernandez, M., Wang, J., Wu, S., Wang, R., Lou, Z., Moroney, J. B., Rivera, C. E., Taylor, J. R., Gan, H., Zan, H., Kovalskyy, D., Liu, D., Casali, P. & Xu, Z., Jun 1 2020, In: Journal of Immunology. 204, 11, p. 3058 1 p.

  Research output: Contribution to journal › Comment/debate › peer-review

  Open Access

  • TNF Receptor-Associated Factor 6
  • Immunoglobulin Class Switching
  • Immunoglobulin Isotypes
  • Allergy and Immunology
  • Names

• Estrogen Reverses HDAC Inhibitor-Mediated Repression of Aicda and Class-Switching in Antibody and Autoantibody Responses by Downregulation of miR-26a

  Casali, P., Shen, T., Xu, Y., Qiu, Z., Chupp, D. P., Im, J., Xu, Z. & Zan, H., Mar 24 2020, In: Frontiers in immunology. 11, 491.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • Immunoglobulin Class Switching
  • Histone Deacetylase Inhibitors
  • Autoantibodies
  • Antibody Formation
  • Genetic Recombination
  3 Scopus citations

• Integrative transcriptome and chromatin landscape analysis reveals distinct epigenetic regulations in human memory B cells

  Moroney, J. B., Vasudev, A., Pertsemlidis, A., Zan, H. & Casali, P., Dec 1 2020, In: Nature communications. 11, 1, 5435.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • chromatin
  • Formal Social Control
  • Cells
  • Transcriptome
  • Epigenomics
  1 Scopus citations
• 2017

  Genome-wide analysis of HDAC inhibitor-mediated modulation of microRNAs and mRNAs in b cells induced to undergo class-switch DNA recombination and plasma cell differentiation

  Sanchez, H. N., Shen, T., Garcia, D., Lai, Z., Casali, P. & Zan, H., Sep 20 2017, In: Journal of Visualized Experiments. 2017, 127, e55135.

  Research output: Contribution to journal › Article › peer-review

  • Histone Deacetylases
  • Messenger RNA
  • Histone Deacetylase Inhibitors
  • DNA
  • Plasma Cells
  1 Scopus citations

• Identification of IL-40, a novel B cell-associated cytokine

  Catalan-Dibene, J., Vazquez, M. I., Luu, V. P., Nuccio, S. P., Karimzadeh, A., Kastenschmidt, J. M., Villalta, S. A., Ushach, I., Pone, E. J., Casali, P., Raffatellu, M., Burkhardt, A. M., Hernandez-Ruiz, M., Heller, G., Hevezi, P. A. & Zlotnik, A., Nov 1 2017, In: Journal of Immunology. 199, 9, p. 3326-3335 10 p.

  Research output: Contribution to journal › Article › peer-review

  • B-Lymphocytes
  • Cytokines
  • Immunoglobulin A
  • Human Mammary Glands
  • Peyer's Patches
  7 Scopus citations

• Rad52 competes with Ku70/Ku86 for binding to S-region DSB ends to modulate antibody class-switch DNA recombination

  Zan, H., Tat, C., Qiu, Z., Taylor, J. R., Guerrero, J. A., Shen, T. & Casali, P., Feb 8 2017, In: Nature communications. 8, 14244.

  Research output: Contribution to journal › Article › peer-review

  • 1,2-di-(4-sulfamidophenyl)-4-butylpyrazolidine-3,5-dione
  • antibodies
  • Immunoglobulin Isotypes
  • Genetic Recombination
  • deoxyribonucleic acid
  14 Scopus citations
• 2016

  Editorial: Epigenetics of B cells and antibody responses

  Zan, H. & Casali, P., 2016, In: Frontiers in immunology. 6, JAN, 656.

  Research output: Contribution to journal › Editorial › peer-review

• Small molecule inhibition of Rab7 impairs B cell class switching and plasma cell survival to dampen the autoantibody response in murine lupus

  Lam, T., Kulp, D. V., Wang, R., Lou, Z., Taylor, J., Rivera, C. E., Yan, H., Zhang, Q., Wang, Z., Zan, H., Ivanov, D. N., Zhong, G., Casali, P. & Xu, Z., Nov 15 2016, In: Journal of Immunology. 197, 10, p. 3792-3805 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoglobulin Class Switching
  • Plasma Cells
  • Autoantibodies
  • B-Lymphocytes
  • Cell Survival
  8 Scopus citations
• 2015

  B cell Rab7 mediates induction of activation-induced cytidine deaminase expression and class-switching in T-dependent and T-independent antibody responses

  Pone, E. J., Lam, T., Lou, Z., Wang, R., Chen, Y., Liu, D., Edinger, A. L., Xu, Z. & Casali, P., Apr 1 2015, In: Journal of Immunology. 194, 7, p. 3065-3078 14 p.

  Research output: Contribution to journal › Article › peer-review

  • AICDA (activation-induced cytidine deaminase)
  • Immunoglobulin Class Switching
  • Genetic Recombination
  • Antibody Formation
  • B-Lymphocytes
  7 Scopus citations

• B cell TLR1/2, TLR4, TLR7 and TLR9 interact in induction of class switch DNA recombination: Modulation by BCR and CD40, and relevance to T-independent antibody responses

  Pone, E. J., Lou, Z., Lam, T., Greenberg, M. L., Wang, R., Xu, Z. & Casali, P., Feb 1 2015, In: Autoimmunity. 48, 1, p. 1-12 12 p.

  Research output: Contribution to journal › Article › peer-review

  • Genetic Recombination
  • Antibody Formation
  • B-Lymphocytes
  • DNA
  • Lipopolysaccharides
  26 Scopus citations

• Epigenetics of peripheral B-cell differentiation and the antibody response

  Zan, H. & Casali, P., 2015, In: Frontiers in immunology. 6, DEC, 631.

  Research output: Contribution to journal › Review article › peer-review

  • Antibody Formation
  • Epigenomics
  • Cell Differentiation
  • B-Lymphocytes
  • Genetic Recombination
  46 Scopus citations

• Genome-wide analysis reveals selective modulation of microRNAs and mRNAs by histone deacetylase inhibitor in B cells induced to undergo class-switch DNA recombination and plasma cell differentiation

  Shen, T., Sanchez, H. N., Zan, H. & Casali, P., 2015, In: Frontiers in immunology. 6, DEC, 627.

  Research output: Contribution to journal › Article › peer-review

  • Histone Deacetylase Inhibitors
  • Plasma Cells
  • Genetic Recombination
  • MicroRNAs
  • Cell Differentiation
  19 Scopus citations

• Regulation of B cell differentiation by intracellular membrane-associated proteins and microRNAs: Role in the antibody response

  Lou, Z., Casali, P. & Xu, Z., 2015, In: Frontiers in immunology. 6, OCT, 537.

  Research output: Contribution to journal › Review article › peer-review

  • Intracellular Membranes
  • Antibody Formation
  • MicroRNAs
  • Membrane Proteins
  • Cell Differentiation
  12 Scopus citations
• 2014

  Histone deacetylase inhibitors upregulate B cell microRNAs that silence AID and blimp-1 expression for epigenetic modulation of antibody and autoantibody responses

  White, C. A., Pone, E. J., Lam, T., Tat, C., Hayama, K. L., Li, G., Zan, H. & Casali, P., Dec 15 2014, In: Journal of Immunology. 193, 12, p. 5933-5950 18 p.

  Research output: Contribution to journal › Article › peer-review

  • Positive Regulatory Domain I-Binding Factor 1
  • AICDA (activation-induced cytidine deaminase)
  • Histone Deacetylase Inhibitors
  • Autoantibodies
  • Antibody Formation
  57 Scopus citations

• MicroRNAs in lupus

  Zan, H., Tat, C. & Casali, P., Jun 2014, In: Autoimmunity. 47, 4, p. 272-285 14 p.

  Research output: Contribution to journal › Review article › peer-review

  • MicroRNAs
  • Epigenomics
  • Histones
  • Antibody Formation
  • Autoimmune Diseases
  44 Scopus citations

• Type II Toxoplasma gondii induction of CD40 on infected macrophages enhances interleukin-12 responses

  Morgado, P., Sudarshana, D. M., Gov, L., Harker, K. S., Lam, T., Casali, P., Boyle, J. P. & Lodoen, M. B., 2014, In: Infection and immunity. 82, 10, p. 4047-4055 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Toxoplasma
  • Interleukin-12
  • Parasites
  • Macrophages
  • X-Linked Genes
  20 Scopus citations
• 2013

  APRIL stimulates NF-κB-mediated HoxC4 induction for AID expression in mouse B cells

  Park, S. R., Kim, P. H., Lee, K. S., Lee, S. H., Seo, G. Y., Yoo, Y. C., Lee, J. & Casali, P., Feb 2013, In: Cytokine. 61, 2, p. 608-613 6 p.

  Research output: Contribution to journal › Article › peer-review

  • AICDA (activation-induced cytidine deaminase)
  • Cells
  • B-Lymphocytes
  • Ligands
  • Transcription
  12 Scopus citations

• Combinatorial H3K9acS10ph histone modification in igh locus s regions targets 14-3-3 adaptors and aid to specify antibody class-switch DNA recombination

  Li, G., White, C. A., Lam, T., Pone, E. J., Tran, D. C., Hayama, K. L., Zan, H., Xu, Z. & Casali, P., 2013, In: Cell Reports. 5, 3, p. 702-714 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Immunoglobulin Isotypes
  • Histone Code
  • AICDA (activation-induced cytidine deaminase)
  • Genetic Recombination
  • Histones
  31 Scopus citations

• Epigenetics of the antibody response

  Li, G., Zan, H., Xu, Z. & Casali, P., Sep 2013, In: Trends in Immunology. 34, 9, p. 460-470 11 p.

  Research output: Contribution to journal › Review article › peer-review

  • Antibody Formation
  • Epigenomics
  • B-Lymphocytes
  • Plasma Cells
  • DNA Methylation
  57 Scopus citations

• Induction of activation-induced cytidine deaminase-targeting adaptor 14-3-3γ is mediated by NF-κB-dependent recruitment of CFP1 to the 5′-CpG-3′-rich 14-3-3γ promoter and is sustained by E2A

  Mai, T., Pone, E. J., Li, G., Lam, T. S., Moehlman, J., Xu, Z. & Casali, P., Aug 15 2013, In: Journal of Immunology. 191, 4, p. 1895-1906 12 p.

  Research output: Contribution to journal › Article › peer-review

  • AICDA (activation-induced cytidine deaminase)
  • Genetic Recombination
  • DNA
  • B-Lymphocytes
  • E-Box Elements
  10 Scopus citations

• Regulation of Aicda expression and AID activity

  Zan, H. & Casali, P., 2013, In: Autoimmunity. 46, 2, p. 83-101 19 p.

  Research output: Contribution to journal › Review article › peer-review

  • AICDA (activation-induced cytidine deaminase)
  • Genetic Recombination
  • DNA
  • B-Lymphocytes
  • Immunoglobulin Genes
  74 Scopus citations

• Scaffold functions of 14-3-3 adaptors in B cell immunoglobulin class switch DNA recombination

  Lam, T., Thomas, L. M., White, C. A., Li, G., Pone, E. J., Xu, Z. & Casali, P., Nov 25 2013, In: PloS one. 8, 11, e80414.

  Research output: Contribution to journal › Article › peer-review

  • cytidine deaminase
  • AICDA (activation-induced cytidine deaminase)
  • Scaffolds
  • Immunoglobulin Isotypes
  • B-lymphocytes
  20 Scopus citations

• TSPAN33 is a novel marker of activated and malignant B cells

  Luu, V. P., Hevezi, P., Vences-Catalan, F., Maravillas-Montero, J. L., White, C. A., Casali, P., Llorente, L., Jakez-Ocampo, J., Lima, G., Vilches-Cisneros, N., Flores-Gutiérrez, J. P., Santos-Argumedo, L. & Zlotnik, A., Dec 2013, In: Clinical Immunology. 149, 3 PB, p. 388-399 12 p.

  Research output: Contribution to journal › Article › peer-review

  • B-Lymphocytes
  • Systemic Lupus Erythematosus
  • Autoimmune Diseases
  • Inbred MRL lpr Mouse
  • Tetraspanins
  19 Scopus citations
• 2012

  BCR-signalling synergizes with TLR-signalling for induction of AID and immunoglobulin class-switching through the non-canonical NF-κB pathway

  Pone, E. J., Zhang, J., Mai, T., White, C. A., Li, G., Sakakura, J. K., Patel, P. J., Al-Qahtani, A., Zan, H., Xu, Z. & Casali, P., 2012, In: Nature communications. 3, 767.

  Research output: Contribution to journal › Article › peer-review

  • AICDA (activation-induced cytidine deaminase)
  • Immunoglobulin Class Switching
  • Immunoglobulin Isotypes
  • Toll-Like Receptors
  • Genetic Recombination
  133 Scopus citations

• Immunoglobulin class-switch DNA recombination: Induction, targeting and beyond

  Xu, Z., Zan, H., Pone, E. J., Mai, T. & Casali, P., Jul 2012, In: Nature Reviews Immunology. 12, 7, p. 517-531 15 p.

  Research output: Contribution to journal › Review article › peer-review

  • Immunoglobulin Isotypes
  • Genetic Recombination
  • DNA
  • Immunoglobulin Heavy Chains
  • Cytidine Deaminase
  219 Scopus citations

• Iron inhibits activation-induced cytidine deaminase enzymatic activity and modulates immunoglobulin class switch DNA recombination

  Li, G., Pone, E. J., Tran, D. C., Patel, P. J., Dao, L., Xu, Z. & Casali, P., Jun 15 2012, In: Journal of Biological Chemistry. 287, 25, p. 21520-21529 10 p.

  Research output: Contribution to journal › Article › peer-review

  • AICDA (activation-induced cytidine deaminase)
  • Immunoglobulin Isotypes
  • Genetic Recombination
  • Iron
  • Switches
  9 Scopus citations

• Rev1 Recruits Ung to Switch Regions and Enhances dU Glycosylation for Immunoglobulin Class Switch DNA Recombination

  Zan, H., White, C. A., Thomas, L. M., Mai, T., Li, G., Xu, Z., Zhang, J. & Casali, P., Nov 29 2012, In: Cell Reports. 2, 5, p. 1220-1232 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Glycosylation
  • Uracil-DNA Glycosidase
  • Deoxyuridine
  • Immunoglobulin Isotypes
  • Genetic Recombination
  27 Scopus citations