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• 2011

  AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

  Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J. Y. J., Gao, B., Wierzbicki, M., Verbeuren, T. J., Shaw, R. J., Cohen, R. A. & Zang, M., Apr 6 2011, In: Cell Metabolism. 13, 4, p. 376-388 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Sterol Regulatory Element Binding Protein 1
  • Atherosclerosis
  • Diet
  • Insulin
  • Liver
  852 Scopus citations

• Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

  Li, Y., Xu, S., Giles, A., Nakamura, K., Lee, J. W., Hou, X., Donmez, G., Li, J., Luo, Z., Walsh, K., Guarente, L. & Zang, M., May 2011, In: FASEB Journal. 25, 5, p. 1664-1679 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Liver
  • Endoplasmic Reticulum Stress
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Insulin Resistance
  204 Scopus citations

• High-fat diet increases and the polyphenol, s17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice

  Xu, S., Jiang, B., Hou, X., Shi, C., Bachschmid, M. M., Zang, M., Verbeuren, T. J. & Cohen, R. A., Sep 2011, In: Journal of Cardiovascular Pharmacology. 58, 3, p. 263-271 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one
  • Sirtuin 1
  • Polyphenols
  • Acetylation
  • High Fat Diet
  21 Scopus citations
• 2014

  Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21

  Li, Y., Wong, K., Giles, A., Jiang, J., Lee, J. W., Adams, A. C., Kharitonenkov, A., Yang, Q., Gao, B., Guarente, L. & Zang, M., Feb 2014, In: Gastroenterology. 146, 2, p. 539-549.e7

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor 21
  • Liver
  • SRT1720
  • Energy Metabolism
  • Fasting
  161 Scopus citations
• 2015

  New insight into metformin action: Regulation of chREBP and FOXO1 activities in endothelial cells

  Li, X., Kover, K. L., Heruth, D. P., Watkins, D. J., Moore, W. V., Jackson, K., Zang, M., Clements, M. A. & Yan, Y., Jul 31 2015, In: Molecular Endocrinology. 29, 8, p. 1184-1194 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Metformin
  • Thioredoxins
  • Endothelial Cells
  • Glucose
  • Proteins
  20 Scopus citations

• The molecular basis of hepatic de novo lipogenesis in insulin resistance

  Zang, M., Jan 1 2015, Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer International Publishing, p. 33-58 26 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Lipogenesis
  • Protein Kinases
  • Insulin Resistance
  • Insulin
  • Sterol Regulatory Element Binding Proteins
  2 Scopus citations
• 2016

  AMPK activation by metformin suppresses abnormal extracellular matrix remodeling in adipose tissue and ameliorates insulin resistance in obesity

  Luo, T., Nocon, A., Fry, J., Sherban, A., Rui, X., Jiang, B., Xu, X. J., Han, J., Yan, Y., Yang, Q., Li, Q. & Zang, M., Aug 1 2016, In: Diabetes. 65, 8, p. 2295-2310 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Metformin
  • Transforming Growth Factors
  • Extracellular Matrix
  • Adipose Tissue
  • Insulin Resistance
  63 Scopus citations

• Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

  Gong, Q., Hu, Z., Zhang, F., Cui, A., Chen, X., Jiang, H., Gao, J., Chen, X., Han, Y., Liang, Q., Ye, D., Shi, L., Chin, Y. E., Wang, Y., Xiao, H., Guo, F., Liu, Y., Zang, M., Xu, A. & Li, Y., Aug 1 2016, In: Hepatology. 64, 2, p. 425-438 14 p.

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor 21
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Insulin Resistance
  • Liver
  58 Scopus citations

• The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells

  Han, J., Weisbrod, R. M., Shao, D., Watanabe, Y., Yin, X., Bachschmid, M. M., Seta, F., Janssen-Heininger, Y. M. W., Matsui, R., Zang, M., Hamburg, N. M. & Cohen, R. A., Oct 1 2016, In: Redox Biology. 9, p. 306-319 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Oxidation-Reduction
  • Protein S
  • Physiological Stress
  • Endothelial Cells
  25 Scopus citations
• 2017

  Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

  Ramirez, T., Li, Y. M., Yin, S., Xu, M. J., Feng, D., Zhou, Z., Zang, M., Mukhopadhyay, P., Varga, Z. V., Pacher, P., Gao, B. & Wang, H., Mar 1 2017, In: Journal of Hepatology. 66, 3, p. 601-609 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sirtuin 1
  • Liver Cirrhosis
  • Down-Regulation
  • Hepatic Stellate Cells
  • Wounds and Injuries
  42 Scopus citations

• Organ-specific alterations in circadian genes by vertical sleeve gastrectomy in an obese diabetic mouse model

  Shen, Q., Yang, Y., Liu, W., Wang, M., Shao, Y., Xu, B., Zhao, X., Zhu, J., Hua, R., Jin, W., Hu, Z., Kim, J. B., Wang, Q., Li, Y., Zang, M., Yao, Q. & Zhang, Z., 2017, In: Science Bulletin. 62, 7, p. 467-469 3 p.

  Research output: Contribution to journal › Article › peer-review
  2 Scopus citations

• Thioredoxin-interacting protein promotes high-glucose-induced macrovascular endothelial dysfunction

  Li, X., Kover, K. L., Heruth, D. P., Watkins, D. J., Guo, Y., Moore, W. V., He, L. G., Zang, M., Clements, M. A. & Yan, Y., Nov 4 2017, In: Biochemical and Biophysical Research Communications. 493, 1, p. 291-297 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Thioredoxins
  • Glucose
  • Medical problems
  • Proteins
  • Type 1 Diabetes Mellitus
  10 Scopus citations
• 2018

  DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

  Chen, H., Shen, F., Sherban, A., Nocon, A., Li, Y., Wang, H., Xu, M. J., Rui, X., Han, J., Jiang, B., Lee, D., Li, N., Keyhani-Nejad, F., Fan, J. G., Liu, F., Kamat, A., Musi, N., Guarente, L., Pacher, P., Gao, B. & 1 others, Zang, M., Aug 2018, In: Hepatology. 68, 2, p. 496-514 19 p.

  Research output: Contribution to journal › Article › peer-review

  • 1-(2-(dodecyloxy)ethyl)pyrrolidine hydrochloride
  • Alcoholic Liver Diseases
  • Lipogenesis
  • Mechanistic Target of Rapamycin Complex 1
  • Liver
  17 Scopus citations