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  • Thomas F Patterson
2020

Fosmanogepix (APX001) is effective in the treatment of pulmonary murine mucormycosis due to rhizopus arrhizus

Gebremariam, T., Alkhazraji, S., Alqarihi, A., Wiederhold, N. P., Shaw, K. J., Patterson, T. F., Filler, S. G. & Ibrahim, A. S., Jun 2020, In : Antimicrobial agents and chemotherapy. 64, 6, e00178-20.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Fungal Infections Potentiated by Biologics

Davis, M. R., Thompson, G. R. & Patterson, T. F., Jun 2020, In : Infectious disease clinics of North America. 34, 2, p. 389-411 23 p.

Research output: Contribution to journalReview article

Open Access

The novel arylamidine T-2307 demonstrates in vitro and in vivo Activity against Candida auris

Wiederhold, N. P., Najvar, L. K., Jaramillo, R., Olivo, M., Patterson, H., Connell, A., Fukuda, Y., Mitsuyama, J., Catano, G. & Patterson, T. F., Jan 1 2020, In : Antimicrobial agents and chemotherapy. 64, 3, e02198.

Research output: Contribution to journalArticle

2019

Blastomyces helicus, a New Dimorphic Fungus Causing Fatal Pulmonary and Systemic Disease in Humans and Animals in Western Canada and the United States

Schwartz, I. S., Wiederhold, N. P., Hanson, K. E., Patterson, T. F. & Sigler, L., Jan 7 2019, In : Clinical Infectious Diseases. 68, 2, p. 188-196 9 p.

Research output: Contribution to journalArticle

15 Scopus citations

Current Concepts and Future Directions in the Pharmacology and Treatment of Coccidioidomycosis

Thompson, G. R., Lewis, J. S., Nix, D. E. & Patterson, T. F., Feb 1 2019, In : Medical Mycology. 57, 1, p. S76-S84

Research output: Contribution to journalArticle

8 Scopus citations

Efficacy of delayed therapy with fosmanogepix (APX001) in a murine model of candida auris invasive candidiasis

Wiederhold, N. P., Najvar, L. K., Shaw, K. J., Jaramillo, R., Patterson, H., Olivo, M., Catano, G. & Patterson, T. F., 2019, In : Antimicrobial agents and chemotherapy. 63, 11, e01120-19.

Research output: Contribution to journalArticle

6 Scopus citations

Extended-Interval Dosing of Rezafungin against Azole-Resistant Aspergillus fumigatus

Wiederhold, N. P., Najvar, L. K., Jaramillo, R., Olivo, M., Wickes, B. L., Catano, G. & Patterson, T. F., 2019, In : Antimicrobial agents and chemotherapy. 63, 10, e01165-19.

Research output: Contribution to journalArticle

Open Access
4 Scopus citations

New concepts in diagnostics for invasive mycoses: Non-culture-based methodologies

Patterson, T. F. & Donnelly, J. P., Mar 2019, In : Journal of Fungi. 5, 1, 9.

Research output: Contribution to journalReview article

Open Access
14 Scopus citations

The Fungal Cyp51-Specific Inhibitor VT-1598 Demonstrates In Vitro and In Vivo Activity against Candida auris

Wiederhold, N. P., Lockhart, S. R., Najvar, L. K., Berkow, E. L., Jaramillo, R., Olivo, M., Garvey, E. P., Yates, C. M., Schotzinger, R. J., Catano, G. & Patterson, T. F., Mar 2019, In : Antimicrobial agents and chemotherapy. 63, 3, e02233-18.

Research output: Contribution to journalArticle

12 Scopus citations

Utility of CT assessment in hematology patients with invasive aspergillosis: A post-hoc analysis of phase 3 data

Jin, J., Wu, D., Liu, Y., Pan, S., Yan, J. L., Aram, J. A., Lou, Y. J., Meng, H., Chen, X., Zhang, XA., Schwartz, I. S. & Patterson, T. F., May 28 2019, In : BMC Infectious Diseases. 19, 1, 471.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations
2018

Agents of Hyalohyphomycosis and Phaeohyphomycosis

Patterson, T. F. & Sutton, D. A., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1244-1247.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

Agents of Mucormycosis

Patterson, T. F. & Sutton, D. A., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1247-1250.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

Classification of Fungi

Patterson, T. F. & Sutton, D. A., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1229-1231.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

Cryptococcus Species

Thompson, G. R. & Patterson, T. F., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1255-1259.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

Emergomyces canadensis, a dimorphic fungus causing fatal systemic human disease in North America

Schwartz, I. S., Sanche, S., Wiederhold, N. P., Patterson, T. F. & Sigler, L., Apr 2018, In : Emerging Infectious Diseases. 24, 4, p. 758-761 4 p.

Research output: Contribution to journalArticle

13 Scopus citations

Erratum for Mor et al., "Identification of a New Class of Antifungals Targeting the Synthesis of Fungal Sphingolipids"

Mor, V., Rella, A., Farnoud, A. M., Singh, A., Munshi, M., Bryan, A., Naseem, S., Konopka, J. B., Ojima, I., Bullesbach, E., Ashbaugh, A., Linke, M. J., Cushion, M., Collins, M., Ananthula, H. K., Sallans, L., Desai, P. B., Wiederhold, N. P., Fothergill, A. W., Kirkpatrick, W. R. & 15 others, Patterson, T., Wong, L. H., Sinha, S., Giaever, G., Nislow, C., Flaherty, P., Pan, X., Cesar, G. V., de Melo Tavares, P., Frases, S., Miranda, K., Rodrigues, M. L., Luberto, C., Nimrichter, L. & Del Poeta, M., Mar 13 2018, In : mBio. 9, 2, e00188-18.

Research output: Contribution to journalComment/debate

3 Scopus citations

Impact of unresolved neutropenia in patients with neutropenia and invasive aspergillosis: A post hoc analysis of the SECURE trial

Kontoyiannis, D. P., Selleslag, D., Mullane, K., Cornely, O. A., Hope, W., Lortholary, O., Croos-Dabrera, R., Lademacher, C., Engelhardt, M. & Patterson, T. F., Mar 1 2018, In : Journal of Antimicrobial Chemotherapy. 73, 3, p. 757-763 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

In vivo efficacy of VT-1129 against experimental cryptococcal meningitis with the use of a loading dose-maintenance dose administration strategy

Wiederhold, N. P., Xu, X., Wang, A., Najvar, L. K., Garvey, E. P., Ottinger, E. A., Alimardanov, A., Cradock, J., Behnke, M., Hoekstra, W. J., Brand, S. R., Schotzinger, R. J., Jaramillo, R., Olivo, M., Kirkpatrick, W. R. & Pattersona, T. F., Nov 2018, In : Antimicrobial agents and chemotherapy. 62, 11, e01315-18.

Research output: Contribution to journalArticle

6 Scopus citations

Malassezia Species

Sutton, D. A. & Patterson, T. F., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1250-1253.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

Novel approaches to antifungal therapy

Thompson, G. R. & Patterson, T. F., Feb 1 2018, In : American Journal of Transplantation. 18, 2, p. 287-288 2 p.

Research output: Contribution to journalEditorial

1 Scopus citations

Oral glucan synthase inhibitor SCY-078 is effective in an experimental murine model of invasive candidiasis caused by WT and echinocandin-resistant Candida glabrata

Wiederhold, N., Najvar, L. K., Jaramillo, R., Olivo, M., Pizzini, J., Catano, G. & Patterson, T. F., Feb 1 2018, In : The Journal of antimicrobial chemotherapy. 73, 2, p. 448-451 4 p.

Research output: Contribution to journalArticle

12 Scopus citations

Screening a repurposing library for inhibitors of multidrug-resistant candida auris identifies ebselen as a repositionable candidate for antifungal drug development

Wall, G., Chaturvedi, A. K., Wormley, F. L., Wiederhold, N. P., Patterson, H. P., Patterson, T. F. & Lopez-Ribot, J. L., Oct 2018, In : Antimicrobial agents and chemotherapy. 62, 10, e01084.

Research output: Contribution to journalArticle

14 Scopus citations

Sporothrix schenckii Complex (Sporotrichosis)

Patterson, T. F. & Sutton, D. A., Jan 1 2018, Principles and Practice of Pediatric Infectious Diseases. Elsevier Inc., p. 1253-1255.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

The Emerging Threat of Antifungal Resistance in Transplant Infectious Diseases

Schwartz, I. S. & Patterson, T. F., Mar 1 2018, In : Current Infectious Disease Reports. 20, 3, 2.

Research output: Contribution to journalReview article

18 Scopus citations

The fungal cyp51 inhibitor vt-1129 is efficacious in an experimental model of cryptococcal meningitis

Wiederhold, N. P., Najvar, L. K., Garvey, E. P., Brand, S. R., Xu, X., Ottinger, E. A., Alimardanov, A., Cradock, J., Behnke, M., Hoekstra, W. J., Schotzinger, R. J., Jaramillo, R., Olivo, M., Kirkpatrick, W. R. & Patterson, T. F., Sep 2018, In : Antimicrobial agents and chemotherapy. 62, 9, e01071-18.

Research output: Contribution to journalArticle

7 Scopus citations

The novel fungal Cyp51 inhibitor VT-1598 is efficacious in experimental models of central nervous system coccidioidomycosis caused by Coccidioides posadasii and Coccidioides immitis

Wiederhold, N. P., Shubitz, L. F., Najvar, L. K., Jaramillo, R., Olivo, M., Catano, G., Trinh, H. T., Yates, C. M., Schotzinger, R. J., Garvey, E. P. & Patterson, T. F., Apr 2018, In : Antimicrobial agents and chemotherapy. 62, 4, e02258-17.

Research output: Contribution to journalArticle

16 Scopus citations

The orotomide olorofim is efficacious in an experimental model of central nervous system coccidioidomycosis

Wiederhold, N. P., Najvar, L. K., Jaramillo, R., Olivo, M., Birch, M., Law, D., Rex, J. H., Catano, G. & Patterson, T. F., Sep 2018, In : Antimicrobial agents and chemotherapy. 62, 9, e00999-18.

Research output: Contribution to journalArticle

8 Scopus citations
2017

Multidrug-Resistant Candida: Epidemiology, Molecular Mechanisms, and Treatment

Arendrup, M. C. & Patterson, T. F., Aug 15 2017, In : The Journal of infectious diseases. 216, 3, p. S445-S451

Research output: Contribution to journalReview article

116 Scopus citations

Prophylactic treatment with VT-1161 protects immunosuppressed mice from rhizopus arrhizus var. Arrhizus infection

Gebremariam, T., Alkhazraji, S., Lin, L., Wiederhold, N. P., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Patterson, T. F., Filler, S. G. & Ibrahim, A. S., Sep 2017, In : Antimicrobial agents and chemotherapy. 61, 9, e00390-17.

Research output: Contribution to journalArticle

10 Scopus citations

The carbohydrate lectin receptor dectin-1 mediates the immune response to Exserohilum rostratum

Reedy, J. L., Negoro, P. E., Feliu, M., Lord, A. K., Khan, N. S., Lukason, D. P., Wiederholdc, N. P., Tam, J. M., Mansour, M. K., Patterson, T. F. & Vyas, J. M., 2017, In : Infection and immunity. 85, 3, e00903.

Research output: Contribution to journalArticle

6 Scopus citations
2016

Effect of antifungal treatment in a diet-based murine model of disseminated candidiasis acquired via the gastrointestinal tract

Kadosh, D., Najvar, L. K., Bocanegra, R., Olivo, M., Kirkpatrick, W. R., Wiederhold, N. & Patterson, T. F., Nov 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 11, p. 6703-6708 6 p.

Research output: Contribution to journalArticle

6 Scopus citations

Executive summary: Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the infectious diseases society of America

Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., Segal, B. H., Steinbach, W. J., Stevens, D. A., Walsh, T. J., Wingard, J. R., Young, J. A. H. & Bennett, J. E., Aug 15 2016, In : Clinical Infectious Diseases. 63, 4, p. 433-442 10 p.

Research output: Contribution to journalReview article

175 Scopus citations
36 Scopus citations

Isavuconazole is effective for the treatment of experimental cryptococcal meningitis

Wiederhold, N., Kovanda, L., Najvar, L. K., Bocanegra, R., Olivo, M., Kirkpatrick, W. R. & Patterson, T. F., Sep 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 9, p. 5600-5603 4 p.

Research output: Contribution to journalArticle

24 Scopus citations

Isavuconazole versus voriconazole for primary treatment of invasive mould disease caused by Aspergillus and other filamentous fungi (SECURE): A phase 3, randomised-controlled, non-inferiority trial

Maertens, J. A., Raad, I. I., Marr, K. A., Patterson, T. F., Kontoyiannis, D. P., Cornely, O. A., Bow, E. J., Rahav, G., Neofytos, D., Aoun, M., Baddley, J. W., Giladi, M., Heinz, W. J., Herbrecht, R., Hope, W., Karthaus, M., Lee, D. G., Lortholary, O., Morrison, V. A., Oren, I. & 8 others, Selleslag, D., Shoham, S., Thompson, G. R., Lee, M., Maher, R. M., Schmitt-Hoffmann, A. H., Zeiher, B. & Ullmann, A. J., Feb 20 2016, In : The Lancet. 387, 10020, p. 760-769 10 p.

Research output: Contribution to journalArticle

340 Scopus citations

Modified release itraconazole amorphous solid dispersion to treat Aspergillus fumigatus: importance of the animal model selection

Maincent, J. P., Najvar, L. K., Kirkpatrick, W. R., Huang, S., Patterson, T. F., Wiederhold, N., Peters, J. I. & Williams, R. O., Oct 5 2016, (Accepted/In press) In : Drug Development and Industrial Pharmacy. p. 1-11 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

Practice guidelines for the diagnosis and management of aspergillosis: 2016 update by the infectious diseases society of America

Patterson, T. F., Thompson, G. R., Denning, D. W., Fishman, J. A., Hadley, S., Herbrecht, R., Kontoyiannis, D. P., Marr, K. A., Morrison, V. A., Nguyen, M. H., Segal, B. H., Steinbach, W. J., Stevens, D. A., Walsh, T. J., Wingard, J. R., Young, J. A. H. & Bennett, J. E., Aug 15 2016, In : Clinical Infectious Diseases. 63, 4, p. e1-e60

Research output: Contribution to journalReview article

714 Scopus citations

Repurposing auranofin as an antifungal: In vitro activity against a variety of medically important fungi

Wiederhold, N., Patterson, T. F., Srinivasan, A., Chaturvedi, A. K., Fothergill, A. W., Wormley, F. L., Ramasubramanian, A. K. & Lopez-Ribot, J. L., Jun 24 2016, (Accepted/In press) In : Virulence. p. 1-5 5 p.

Research output: Contribution to journalArticle

23 Scopus citations

The celecoxib derivative AR-12 has broad-spectrum antifungal activity in vitro and improves the activity of fluconazole in a murine model of cryptococcosis

Koselny, K., Green, J., DiDone, L., Halterman, J. P., Fothergill, A. W., Wiederhold, N., Patterson, T. F., Cushion, M. T., Rappelye, C., Wellington, M. & Krysan, D. J., Dec 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 12, p. 7115-7127 13 p.

Research output: Contribution to journalArticle

32 Scopus citations
59 Scopus citations

The investigational fungal Cyp51 inhibitor VT-1129 demonstrates potent in vitro activity against cryptococcus neoformans and cryptococcus gattii

Lockhart, S. R., Fothergill, A. W., Iqbal, N., Bolden, C. B., Grossman, N. T., Garvey, E. P., Brand, S. R., Hoekstra, W. J., Schotzinger, R. J., Ottinger, E., Patterson, T. F. & Wiederhold, N., Apr 1 2016, In : Antimicrobial Agents and Chemotherapy. 60, 4, p. 2528-2531 4 p.

Research output: Contribution to journalArticle

36 Scopus citations

The novel arylamidine T-2307 demonstrates in vitro and in vivo activity against echinocandin-resistant Candida glabrata

Wiederhold, N. P., Najvar, L. K., Fothergill, A. W., Bocanegra, R., Olivo, M., McCarthy, D. I., Fukuda, Y., Mitsuyama, J. & Patterson, T. F., Mar 1 2016, In : Journal of Antimicrobial Chemotherapy. 71, 3, p. 692-695 4 p.

Research output: Contribution to journalArticle

11 Scopus citations
2015

Antifungal agents

Thompson, G. R. & Patterson, T. F., Jan 1 2015, Infections in Hematology. Springer Berlin Heidelberg, p. 259-272 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Antifungal therapy

Wiederhold, N. & Patterson, T. F., Jan 1 2015, Clinical Infectious Disease, Second Edition. Cambridge University Press, p. 1344-1352 9 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

52 Scopus citations

Aspergillosis

Boucher, H. W. & Patterson, T. F., Jan 1 2015, Diagnosis and Treatment of Fungal Infections. Springer International Publishing, p. 129-140 12 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

Aspergillus Polymerase Chain Reaction: Systematic Review of Evidence for Clinical Use in Comparison with Antigen Testing

White, P. L., Wingard, J. R., Bretagne, S., Löffler, J., Patterson, T. F., Slavin, M. A., Barnes, R. A., Pappas, P. G. & Donnelly, J. P., Oct 15 2015, In : Clinical Infectious Diseases. 61, 8, p. 1293-1303 11 p.

Research output: Contribution to journalArticle

96 Scopus citations

Efficacy of the investigational echinocandin ASP9726 in a guinea pig model of invasive pulmonary aspergillosis

Wiederhold, N., Najvar, L. K., Matsumoto, S., Bocanegra, R. A., Herrera, M. L., Wickes, B. L., Kirkpatrick, W. R. & Patterson, T. F., May 1 2015, In : Antimicrobial Agents and Chemotherapy. 59, 5, p. 2875-2881 7 p.

Research output: Contribution to journalArticle

11 Scopus citations

Emergence of Azole Resistance in Aspergillus

Wiederhold, N. & Patterson, T. F., Oct 25 2015, In : Seminars in Respiratory and Critical Care Medicine. 36, 5, p. 673-680 8 p.

Research output: Contribution to journalArticle

28 Scopus citations