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  • Mengwei Zang

Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity

Wang, H., Shen, L., Sun, X., Liu, F., Feng, W., Jiang, C., Chu, X., Ye, X., Jiang, C., Wang, Y., Zhang, P., Zang, M., Zhu, D. & Bi, Y., Dec 1 2019, In : Nature communications. 10, 1, 3254.

Research output: Contribution to journalArticle

Open Access
10 Scopus citations

Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis

Morita, M., Siddiqui, N., Katsumura, S., Rouya, C., Larsson, O., Nagashima, T., Hekmatnejad, B., Takahashi, A., Kiyonari, H., Zang, M., St-Arnaud, R., Oike, Y., Giguère, V., Topisirovic, I., Okada-Hatakeyama, M., Yamamoto, T. & Sonenberg, N., Apr 16 2019, In : Proceedings of the National Academy of Sciences of the United States of America. 116, 16, p. 7973-7981 9 p.

Research output: Contribution to journalArticle

5 Scopus citations

DEP domain–containing mTOR–interacting protein suppresses lipogenesis and ameliorates hepatic steatosis and acute-on-chronic liver injury in alcoholic liver disease

Chen, H., Shen, F., Sherban, A., Nocon, A., Li, Y., Wang, H., Xu, M. J., Rui, X., Han, J., Jiang, B., Lee, D., Li, N., Keyhani-Nejad, F., Fan, J. G., Liu, F., Kamat, A., Musi, N., Guarente, L., Pacher, P., Gao, B. & 1 others, Zang, M., Aug 2018, In : Hepatology. 68, 2, p. 496-514 19 p.

Research output: Contribution to journalArticle

13 Scopus citations

AMPK activation by metformin suppresses abnormal extracellular matrix remodeling in adipose tissue and ameliorates insulin resistance in obesity

Luo, T., Nocon, A., Fry, J., Sherban, A., Rui, X., Jiang, B., Xu, X. J., Han, J., Yan, Y., Yang, Q., Li, Q. & Zang, M., Aug 1 2016, In : Diabetes. 65, 8, p. 2295-2310 16 p.

Research output: Contribution to journalArticle

57 Scopus citations

Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

Gong, Q., Hu, Z., Zhang, F., Cui, A., Chen, X., Jiang, H., Gao, J., Chen, X., Han, Y., Liang, Q., Ye, D., Shi, L., Chin, Y. E., Wang, Y., Xiao, H., Guo, F., Liu, Y., Zang, M., Xu, A. & Li, Y., Aug 1 2016, In : Hepatology. 64, 2, p. 425-438 14 p.

Research output: Contribution to journalArticle

53 Scopus citations

The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells

Han, J., Weisbrod, R. M., Shao, D., Watanabe, Y., Yin, X., Bachschmid, M. M., Seta, F., Janssen-Heininger, Y. M. W., Matsui, R., Zang, M., Hamburg, N. M. & Cohen, R. A., Oct 1 2016, In : Redox Biology. 9, p. 306-319 14 p.

Research output: Contribution to journalArticle

25 Scopus citations

New insight into metformin action: Regulation of chREBP and FOXO1 activities in endothelial cells

Li, X., Kover, K. L., Heruth, D. P., Watkins, D. J., Moore, W. V., Jackson, K., Zang, M., Clements, M. A. & Yan, Y., Jul 31 2015, In : Molecular Endocrinology. 29, 8, p. 1184-1194 11 p.

Research output: Contribution to journalArticle

18 Scopus citations

The molecular basis of hepatic de novo lipogenesis in insulin resistance

Zang, M., Jan 1 2015, Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer International Publishing, p. 33-58 26 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21

Li, Y., Wong, K., Giles, A., Jiang, J., Lee, J. W., Adams, A. C., Kharitonenkov, A., Yang, Q., Gao, B., Guarente, L. & Zang, M., Feb 2014, In : Gastroenterology. 146, 2, p. 539-549.e7

Research output: Contribution to journalArticle

150 Scopus citations

Activation of Sterol Regulatory Element Binding Protein and NLRP3 Inflammasome in Atherosclerotic Lesion Development in Diabetic Pigs

Li, Y., Xu, S., Jiang, B., Cohen, R. A. & Zang, M., Jun 25 2013, In : PloS one. 8, 6, e67532.

Research output: Contribution to journalArticle

46 Scopus citations

Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice

Li, Y., Wong, K., Walsh, K., Gao, B. & Zang, M., Apr 12 2013, In : Journal of Biological Chemistry. 288, 15, p. 10490-10504 15 p.

Research output: Contribution to journalArticle

59 Scopus citations

AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J. Y. J., Gao, B., Wierzbicki, M., Verbeuren, T. J., Shaw, R. J., Cohen, R. A. & Zang, M., Apr 6 2011, In : Cell Metabolism. 13, 4, p. 376-388 13 p.

Research output: Contribution to journalArticle

818 Scopus citations

Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

Li, Y., Xu, S., Giles, A., Nakamura, K., Lee, J. W., Hou, X., Donmez, G., Li, J., Luo, Z., Walsh, K., Guarente, L. & Zang, M., May 2011, In : FASEB Journal. 25, 5, p. 1664-1679 16 p.

Research output: Contribution to journalArticle

194 Scopus citations

High-fat diet increases and the polyphenol, s17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice

Xu, S., Jiang, B., Hou, X., Shi, C., Bachschmid, M. M., Zang, M., Verbeuren, T. J. & Cohen, R. A., Sep 2011, In : Journal of Cardiovascular Pharmacology. 58, 3, p. 263-271 9 p.

Research output: Contribution to journalArticle

21 Scopus citations