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• Activation of Sterol Regulatory Element Binding Protein and NLRP3 Inflammasome in Atherosclerotic Lesion Development in Diabetic Pigs

  Li, Y., Xu, S., Jiang, B., Cohen, R. A. & Zang, M., Jun 25 2013, In: PloS one. 8, 6, e67532.

  Research output: Contribution to journal › Article › peer-review

  • inflammasomes
  • Sterol Regulatory Element Binding Proteins
  • Sterol Regulatory Element Binding Protein 1
  • Inflammasomes
  • sterols
  48 Scopus citations

• Adipose group 1 innate lymphoid cells promote adipose tissue fibrosis and diabetes in obesity

  Wang, H., Shen, L., Sun, X., Liu, F., Feng, W., Jiang, C., Chu, X., Ye, X., Jiang, C., Wang, Y., Zhang, P., Zang, M., Zhu, D. & Bi, Y., Dec 1 2019, In: Nature communications. 10, 1, 3254.

  Research output: Contribution to journal › Article › peer-review

  Open Access

  • obesity
  • fibrosis
  • adipose tissues
  • Medical problems
  • Tissue
  14 Scopus citations

• Aging aggravates alcoholic liver injury and fibrosis in mice by downregulating sirtuin 1 expression

  Ramirez, T., Li, Y. M., Yin, S., Xu, M. J., Feng, D., Zhou, Z., Zang, M., Mukhopadhyay, P., Varga, Z. V., Pacher, P., Gao, B. & Wang, H., Mar 1 2017, In: Journal of Hepatology. 66, 3, p. 601-609 9 p.

  Research output: Contribution to journal › Article › peer-review

  • Sirtuin 1
  • Liver Cirrhosis
  • Down-Regulation
  • Hepatic Stellate Cells
  • Wounds and Injuries
  40 Scopus citations

• AMPK activation by metformin suppresses abnormal extracellular matrix remodeling in adipose tissue and ameliorates insulin resistance in obesity

  Luo, T., Nocon, A., Fry, J., Sherban, A., Rui, X., Jiang, B., Xu, X. J., Han, J., Yan, Y., Yang, Q., Li, Q. & Zang, M., Aug 1 2016, In: Diabetes. 65, 8, p. 2295-2310 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Metformin
  • Transforming Growth Factors
  • Extracellular Matrix
  • Adipose Tissue
  • Insulin Resistance
  62 Scopus citations

• AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice

  Li, Y., Xu, S., Mihaylova, M. M., Zheng, B., Hou, X., Jiang, B., Park, O., Luo, Z., Lefai, E., Shyy, J. Y. J., Gao, B., Wierzbicki, M., Verbeuren, T. J., Shaw, R. J., Cohen, R. A. & Zang, M., Apr 6 2011, In: Cell Metabolism. 13, 4, p. 376-388 13 p.

  Research output: Contribution to journal › Article › peer-review

  • Sterol Regulatory Element Binding Protein 1
  • Atherosclerosis
  • Diet
  • Insulin
  • Liver
  852 Scopus citations

• Fibroblast growth factor 21 improves hepatic insulin sensitivity by inhibiting mammalian target of rapamycin complex 1 in mice

  Gong, Q., Hu, Z., Zhang, F., Cui, A., Chen, X., Jiang, H., Gao, J., Chen, X., Han, Y., Liang, Q., Ye, D., Shi, L., Chin, Y. E., Wang, Y., Xiao, H., Guo, F., Liu, Y., Zang, M., Xu, A. & Li, Y., Aug 1 2016, In: Hepatology. 64, 2, p. 425-438 14 p.

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor 21
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Insulin Resistance
  • Liver
  53 Scopus citations

• Hepatic overexpression of SIRT1 in mice attenuates endoplasmic reticulum stress and insulin resistance in the liver

  Li, Y., Xu, S., Giles, A., Nakamura, K., Lee, J. W., Hou, X., Donmez, G., Li, J., Luo, Z., Walsh, K., Guarente, L. & Zang, M., May 2011, In: FASEB Journal. 25, 5, p. 1664-1679 16 p.

  Research output: Contribution to journal › Article › peer-review

  • Liver
  • Endoplasmic Reticulum Stress
  • Mechanistic Target of Rapamycin Complex 1
  • TOR Serine-Threonine Kinases
  • Insulin Resistance
  200 Scopus citations

• Hepatic posttranscriptional network comprised of CCR4–NOT deadenylase and FGF21 maintains systemic metabolic homeostasis

  Morita, M., Siddiqui, N., Katsumura, S., Rouya, C., Larsson, O., Nagashima, T., Hekmatnejad, B., Takahashi, A., Kiyonari, H., Zang, M., St-Arnaud, R., Oike, Y., Giguère, V., Topisirovic, I., Okada-Hatakeyama, M., Yamamoto, T. & Sonenberg, N., Apr 16 2019, In: Proceedings of the National Academy of Sciences of the United States of America. 116, 16, p. 7973-7981 9 p.

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor 21
  • Homeostasis
  • Tristetraprolin
  • Liver
  • Metabolic Syndrome
  8 Scopus citations

• Hepatic SIRT1 attenuates hepatic steatosis and controls energy balance in mice by inducing fibroblast growth factor 21

  Li, Y., Wong, K., Giles, A., Jiang, J., Lee, J. W., Adams, A. C., Kharitonenkov, A., Yang, Q., Gao, B., Guarente, L. & Zang, M., Feb 2014, In: Gastroenterology. 146, 2, p. 539-549.e7

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor 21
  • Liver
  • SRT1720
  • Energy Metabolism
  • Fasting
  157 Scopus citations

• High-fat diet increases and the polyphenol, s17834, decreases acetylation of the sirtuin-1-dependent lysine-382 on p53 and apoptotic signaling in atherosclerotic lesion-prone aortic endothelium of normal mice

  Xu, S., Jiang, B., Hou, X., Shi, C., Bachschmid, M. M., Zang, M., Verbeuren, T. J. & Cohen, R. A., Sep 2011, In: Journal of Cardiovascular Pharmacology. 58, 3, p. 263-271 9 p.

  Research output: Contribution to journal › Article › peer-review

  • 6,8-diallyl 5,7-dihydroxy 2-(2-allyl 3-hydroxy 4-methoxyphenyl)1-H benzo(b)pyran-4-one
  • Sirtuin 1
  • Polyphenols
  • Acetylation
  • High Fat Diet
  21 Scopus citations

• New insight into metformin action: Regulation of chREBP and FOXO1 activities in endothelial cells

  Li, X., Kover, K. L., Heruth, D. P., Watkins, D. J., Moore, W. V., Jackson, K., Zang, M., Clements, M. A. & Yan, Y., Jul 31 2015, In: Molecular Endocrinology. 29, 8, p. 1184-1194 11 p.

  Research output: Contribution to journal › Article › peer-review

  • Metformin
  • Thioredoxins
  • Endothelial Cells
  • Glucose
  • Proteins
  19 Scopus citations

• Organ-specific alterations in circadian genes by vertical sleeve gastrectomy in an obese diabetic mouse model

  Shen, Q., Yang, Y., Liu, W., Wang, M., Shao, Y., Xu, B., Zhao, X., Zhu, J., Hua, R., Jin, W., Hu, Z., Kim, J. B., Wang, Q., Li, Y., Zang, M., Yao, Q. & Zhang, Z., 2017, In: Science Bulletin. 62, 7, p. 467-469 3 p.

  Research output: Contribution to journal › Article › peer-review
  2 Scopus citations

• Retinoic acid receptor β stimulates hepatic induction of fibroblast growth factor 21 to promote fatty acid oxidation and control whole-body energy homeostasis in mice

  Li, Y., Wong, K., Walsh, K., Gao, B. & Zang, M., Apr 12 2013, In: Journal of Biological Chemistry. 288, 15, p. 10490-10504 15 p.

  Research output: Contribution to journal › Article › peer-review

  • fibroblast growth factor 21
  • Retinoic Acid Receptors
  • Oxidation
  • Fatty Acids
  • Homeostasis
  59 Scopus citations

• The molecular basis of hepatic de novo lipogenesis in insulin resistance

  Zang, M., Jan 1 2015, Hepatic De Novo Lipogenesis and Regulation of Metabolism. Springer International Publishing, p. 33-58 26 p.

  Research output: Chapter in Book/Report/Conference proceeding › Chapter

  • Lipogenesis
  • Protein Kinases
  • Insulin Resistance
  • Insulin
  • Sterol Regulatory Element Binding Proteins
  2 Scopus citations

• The redox mechanism for vascular barrier dysfunction associated with metabolic disorders: Glutathionylation of Rac1 in endothelial cells

  Han, J., Weisbrod, R. M., Shao, D., Watanabe, Y., Yin, X., Bachschmid, M. M., Seta, F., Janssen-Heininger, Y. M. W., Matsui, R., Zang, M., Hamburg, N. M. & Cohen, R. A., Oct 1 2016, In: Redox Biology. 9, p. 306-319 14 p.

  Research output: Contribution to journal › Article › peer-review

  • Endothelial cells
  • Oxidation-Reduction
  • Protein S
  • Physiological Stress
  • Endothelial Cells
  25 Scopus citations

• Thioredoxin-interacting protein promotes high-glucose-induced macrovascular endothelial dysfunction

  Li, X., Kover, K. L., Heruth, D. P., Watkins, D. J., Guo, Y., Moore, W. V., He, L. G., Zang, M., Clements, M. A. & Yan, Y., Nov 4 2017, In: Biochemical and Biophysical Research Communications. 493, 1, p. 291-297 7 p.

  Research output: Contribution to journal › Article › peer-review

  • Thioredoxins
  • Glucose
  • Medical problems
  • Proteins
  • Type 1 Diabetes Mellitus
  9 Scopus citations