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  • Robin J Leach
2020

A copy number gain on 18q present in primary prostate tumors is associated with metastatic outcome

Ashcraft, K. A., Johnson-pais, T. L., Troyer, D. A., Hernandez, J. & Leach, R. J., 2020, (Accepted/In press) In : Urologic Oncology: Seminars and Original Investigations.

Research output: Contribution to journalArticle

A genome-wide association study of prostate cancer in Latinos

Du, Z., Hopp, H., Ingles, S. A., Huff, C., Sheng, X., Weaver, B., Stern, M., Hoffmann, T. J., John, E. M., Van Den Eeden, S. K., Strom, S., Leach, R. J., Thompson, I. M., Witte, J. S., Conti, D. V. & Haiman, C. A., Apr 1 2020, In : International Journal of Cancer. 146, 7, p. 1819-1826 8 p.

Research output: Contribution to journalArticle

A Germline Variant at 8q24 Contributes to Familial Clustering of Prostate Cancer in Men of African Ancestry

Darst, B. F., Wan, P., Sheng, X., Bensen, J. T., Ingles, S. A., Rybicki, B. A., Nemesure, B., John, E. M., Fowke, J. H., Stevens, V. L., Berndt, S. I., Huff, C. D., Strom, S. S., Park, J. Y., Zheng, W., Ostrander, E. A., Walsh, P. C., Srivastava, S., Carpten, J., Sellers, T. A. & 52 others, Yamoah, K., Murphy, A. B., Sanderson, M., Crawford, D. C., Gapstur, S. M., Bush, W. S., Aldrich, M. C., Cussenot, O., Yeager, M., Petrovics, G., Cullen, J., Neslund-Dudas, C., Kittles, R. A., Xu, J., Stern, M. C., Kote-Jarai, Z., Govindasami, K., Chokkalingam, A. P., Multigner, L., Parent, M. E., Menegaux, F., Cancel-Tassin, G., Kibel, A. S., Klein, E. A., Goodman, P. J., Drake, B. F., Hu, J. J., Clark, P. E., Blanchet, P., Casey, G., Hennis, A. J. M., Lubwama, A., Thompson, I. M., Leach, R., Gundell, S. M., Pooler, L., Xia, L., Mohler, J. L., Fontham, E. T. H., Smith, G. J., Taylor, J. A., Eeles, R. A., Brureau, L., Chanock, S. J., Watya, S., Stanford, J. L., Mandal, D., Isaacs, W. B., Cooney, K., Blot, W. J., Conti, D. V. & Haiman, C. A., 2020, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Targeted Mass Spectrometry of a Clinically Relevant PSA Variant from Post-DRE Urines for Quantitation and Genotype Determination

Otto, J. J., Correll, V. L., Engstroem, H. A., Hitefield, N. L., Main, B. P., Albracht, B., Johnson-pais, T. L., Yang, L. F., Liss, M. A., Boutros, P. C., Kislinger, T., Leach, R. J., Semmes, O. J. & Nyalwidhe, J. O., 2020, (Accepted/In press) In : Proteomics - Clinical Applications.

Research output: Contribution to journalArticle

Open Access
2019

Higher baseline dietary fat and fatty acid intake is associated with increased risk of incident prostate cancer in the SABOR study

Liss, M. A., Al-Bayati, O., Gelfond, J., Goros, M., Ullevig, S., DiGiovanni, J., Hamilton-Reeves, J., O’Keefe, D., Bacich, D., Weaver, B., Leach, R. & Thompson, I. M., May 1 2019, In : Prostate Cancer and Prostatic Diseases. 22, 2, p. 244-251 8 p.

Research output: Contribution to journalArticle

5 Scopus citations

Incorporation of Urinary Prostate Cancer Antigen 3 and TMPRSS2:ERG into Prostate Cancer Prevention Trial Risk Calculator

Ankerst, D. P., Goros, M., Tomlins, S. A., Patil, D., Feng, Z., Wei, J. T., Sanda, M. G., Gelfond, J., Thompson, I. M., Leach, R. J. & Liss, M. A., Jan 2019, In : European Urology Focus. 5, 1, p. 54-61 8 p.

Research output: Contribution to journalArticle

4 Scopus citations

Microbiome diversity in carriers of fluoroquinolone resistant escherichia coli

Liss, M. A., Leach, R. J., Rourke, E., Sherrill, A., Johnson-Pais, T., Lai, Z., Basler, J. & White, J. R., Mar 2019, In : Investigative and Clinical Urology. 60, 2, p. 75-83 9 p.

Research output: Contribution to journalArticle

Open Access
1 Scopus citations

Multi-cohort modeling strategies for scalable globally accessible prostate cancer risk tools

Tolksdorf, J., Kattan, M. W., Boorjian, S. A., Freedland, S. J., Saba, K., Poyet, C., Guerrios, L., De Hoedt, A., Liss, M. A., Leach, R. J., Hernandez, J., Vertosick, E., Vickers, A. J. & Ankerst, D. P., Jan 1 2019, In : BMC Medical Research Methodology. 19, 1, 191.

Research output: Contribution to journalArticle

Open Access

Vortioxetine reverses medial prefrontal cortex-mediated cognitive deficits in male rats induced by castration as a model of androgen deprivation therapy for prostate cancer

Sharp, A. M., Lertphinyowong, S., Yee, S. S., Paredes, D., Gelfond, J., Johnson-Pais, T. L., Leach, R. J., Liss, M., Risinger, A. L., Sullivan, A. C., Thompson, I. M. & Morilak, D. A., Nov 1 2019, In : Psychopharmacology. 236, 11, p. 3183-3195 13 p.

Research output: Contribution to journalArticle

1 Scopus citations
2018

A Contemporary Prostate Biopsy Risk Calculator Based on Multiple Heterogeneous Cohorts

Ankerst, D. P., Straubinger, J., Selig, K., Guerrios, L., De Hoedt, A., Hernandez, J., Liss, M. A., Leach, R. J., Freedland, S. J., Kattan, M. W., Nam, R., Haese, A., Montorsi, F., Boorjian, S. A., Cooperberg, M. R., Poyet, C., Vertosick, E. & Vickers, A. J., Aug 2018, In : European Urology. 74, 2, p. 197-203 7 p.

Research output: Contribution to journalArticle

16 Scopus citations

Adipose Tissue-Secreted Factors Alter Bladder Cancer Cell Migration

Hariharan, N., Ashcraft, K. A., Svatek, R. S., Livi, C. B., Wilson, D., Kaushik, D., Leach, R. J. & Johnson-Pais, T. L., 2018, In : Journal of Obesity. 2018, 9247864.

Research output: Contribution to journalArticle

4 Scopus citations

Boolean analysis identifies CD38 as a biomarker of aggressive localized prostate cancer

Sahoo, D., Wei, W., Auman, H., Hurtado-Coll, A., Carroll, P. R., Fazli, L., Gleave, M. E., Lin, D. W., Nelson, P. S., Simko, J., Thompson, I. M., Leach, R. J., Troyer, D. A., True, L. D., McKenney, J. K., Feng, Z. & Brooks, J. D., 2018, In : Oncotarget. 9, 5, p. 6550-6561 12 p.

Research output: Contribution to journalArticle

4 Scopus citations

Circadian genes and risk of prostate cancer in the prostate cancer prevention trial

Chu, L. W., Till, C., Yang, B., Tangen, C. M., Goodman, P. J., Yu, K., Zhu, Y., Han, S., Hoque, A. M., Ambrosone, C., Thompson, I., Leach, R. & Hsing, A. W., Mar 2018, In : Molecular Carcinogenesis. 57, 3, p. 462-466 5 p.

Research output: Contribution to journalArticle

2 Scopus citations

Metabolic Biosynthesis Pathways Identified from Fecal Microbiome Associated with Prostate Cancer

Liss, M. A., White, J. R., Goros, M., Gelfond, J., Leach, R., Johnson-Pais, T., Zhao, L., Rourke, E., Basler, J., Ankerst, D. P. & Shah, D. P., Jan 1 2018, (Accepted/In press) In : European Urology.

Research output: Contribution to journalArticle

21 Scopus citations

The effect of 3-month finasteride challenge on biomarkers for predicting cancer outcome on biopsy: Results of a randomized trial

Hernandez, J., Gelfond, J., Goros, M., Liss, M. A., Liang, Y., Ankerst, D. P., Thompson, I. M. & Leach, R. J., Oct 1 2018, In : PLoS One. 13, 10, e0204823.

Research output: Contribution to journalArticle

2017

Association between variants in genes involved in the immune response and prostate cancer risk in men randomized to the finasteride arm in the Prostate Cancer Prevention Trial

Winchester, D. A., Till, C., Goodman, P. J., Tangen, C. M., Santella, R. M., Johnson-Pais, T. L., Leach, R. J., Xu, J., Zheng, S. L., Thompson, I. M., Lucia, M. S., Lippman, S. M., Parnes, H. L., Isaacs, W. B., De Marzo, A. M., Drake, C. G. & Platz, E. A., Jun 1 2017, In : Prostate. 77, 8, p. 908-919 12 p.

Research output: Contribution to journalArticle

11 Scopus citations

Helicobacter Pylori Infection in Texas Hispanic and Non-Hispanic White Men: Implications for Gastric Cancer Risk Disparities

Long Parma, D., Muñoz, E., Ogden, S. M., Westin, G. F., Leach, R. J., Thompson, I. M. & Ramirez, A. G., Jul 1 2017, In : American Journal of Men's Health. 11, 4, p. 1039-1045 7 p.

Research output: Contribution to journalArticle

3 Scopus citations

Multiplexed targeted mass spectrometry assays for prostate cancer-associated urinary proteins

Shi, T., Quek, S. I., Gao, Y., Nicora, C. D., Nie, S., Fillmore, T. L., Liu, T., Rodland, K. D., Smith, R. D., Leach, R. J., Thompson, I. M., Vitello, E. A., Ellis, W. J., Liu, A. Y. & Qian, W. J., Jan 1 2017, In : Oncotarget. 8, 60, p. 101887-101898 12 p.

Research output: Contribution to journalArticle

3 Scopus citations
2016

Adding genetic risk score to family history identifies twice as many high-risk men for prostate cancer: Results from the prostate cancer prevention trial

Chen, H., Liu, X., Brendler, C. B., Ankerst, D. P., Leach, R. J., Goodman, P. J., Lucia, M. S., Tangen, C. M., Wang, L., Hsu, F. C., Sun, J., Kader, A. K., Isaacs, W. B., Helfand, B. T., Zheng, S. L., Thompson, I. M., Platz, E. A. & Xu, J., Sep 1 2016, In : Prostate. 76, 12, p. 1120-1129 10 p.

Research output: Contribution to journalArticle

25 Scopus citations

Association of androgen metabolism gene polymorphisms with prostate cancer risk and androgen concentrations: Results from the prostate cancer prevention trial

Price, D. K., Chau, C. H., Till, C., Goodman, P. J., Leach, R. J., Johnson-Pais, T. L., Hsing, A. W., Hoque, A., Parnes, H. L., Schenk, J. M., Tangen, C. M., Thompson, I. M., Reichardt, J. K. V. & Figg, W. D., Aug 2016, In : Cancer. 122, 15, p. 2332-2340 9 p.

Research output: Contribution to journalArticle

10 Scopus citations

Key genes involved in the immune response are generally not associated with intraprostatic inflammation in men without a prostate cancer diagnosis: Results from the prostate cancer prevention trial

Winchester, D. A., Gurel, B., Till, C., Goodman, P. J., Tangen, C. M., Santella, R. M., Johnson-Pais, T. L., Leach, R. J., Thompson, I. M., Xu, J., Zheng, S. L., Lucia, M. S., Lippman, S. M., Parnes, H. L., Isaacs, W. B., Drake, C. G., De Marzo, A. M. & Platz, E. A., May 1 2016, In : Prostate. 76, 6, p. 565-574 10 p.

Research output: Contribution to journalArticle

5 Scopus citations

MBDDiff: An R package designed specifically for processing MBDcap-seq datasets

Liu, Y., Wilson, D., Leach, R. J. & Chen, Y., Aug 18 2016, In : BMC Genomics. 17, 432.

Research output: Contribution to journalArticle

2 Scopus citations

Roles of distal and genic methylation in the development of prostate tumorigenesis revealed by genome-wide DNA methylation analysis

Wang, Y., Jadhav, R. R., Liu, J., Wilson, D., Chen, Y., Thompson, I. M., Troyer, D. A., Hernandez, J., Shi, H., Leach, R. J., Huang, T. H. M. & Jin, V. X., Jan 1 2016, In : Scientific reports. 6, 22051.

Research output: Contribution to journalArticle

12 Scopus citations

Serial Percent Free Prostate Specific Antigen in Combination with Prostate Specific Antigen for Population Based Early Detection of Prostate Cancer

Ankerst, D. P., Gelfond, J. A., Goros, M., Herrera, J., Strobl, A., Thompson, I. M., Hernandez, J. & Leach, R. J., Aug 1 2016, In : Journal of Urology. 196, 2, p. 355-360 6 p.

Research output: Contribution to journalArticle

14 Scopus citations
2015

A case control study of sarcosine as an early prostate cancer detection biomarker Urological oncology

Ankerst, D. P., Liss, M. A., Zapata, D., Hoefler, J., Thompson, I. M. & Leach, R. J., Oct 1 2015, In : BMC Urology. 15, 1, 99.

Research output: Contribution to journalArticle

12 Scopus citations

Active surveillance is an appropriate management strategy for a proportion of men diagnosed with prostate cancer by prostate specific antigen testing

Thompson, I. M., Overholser, S., Nielsen, M., Torkko, K., Cwilka, D., Weaver, B., Shi, X., Leach, R. J., Hernandez, J., Huang, H. & Thompson, I. M., Sep 1 2015, In : Journal of Urology. 194, 3, p. 680-684 5 p.

Research output: Contribution to journalArticle

15 Scopus citations

A simple-to-use method incorporating genomic markers into prostate cancer risk prediction tools facilitated future validation

Grill, S., Fallah, M., Leach, R. J., Thompson, I. M., Hemminki, K. & Ankerst, D. P., May 1 2015, In : Journal of Clinical Epidemiology. 68, 5, p. 563-573 11 p.

Research output: Contribution to journalArticle

5 Scopus citations

DNA methylation screening of primary prostate tumors identifies SRD5A2 and CYP11A1 as candidate markers for assessing risk of biochemical recurrence

Horning, A. M., Awe, J. A., Wang, C. M., Liu, J., Lai, Z., Wang, V. Y., Jadhav, R. R., Louie, A. D., Lin, C. L., Kroczak, T., Chen, Y., Jin, V. X., Abboud-Werner, S. L., Leach, R. J., Hernandez, J., Thompson, I. M., Saranchuk, J., Drachenberg, D., Chen, C. L., Mai, S. & 1 others, Huang, T. H. M., 2015, (Accepted/In press) In : Prostate.

Research output: Contribution to journalArticle

11 Scopus citations

Enhancement of performance in porous bead-based microchip sensors: Effects of chip geometry on bio-agent capture

Kulla, E., Chou, J., Simmons, G. W., Wong, J., McRae, M. P., Patel, R., Floriano, P. N., Christodoulides, N., Leach, R. J., Thompson, I. M. & McDevitt, J. T., Jan 1 2015, In : RSC Advances. 5, 60, p. 48194-48206 13 p.

Research output: Contribution to journalArticle

1 Scopus citations

Finasteride concentrations and prostate cancer risk: Results from the prostate cancer prevention trial

Chau, C. H., Price, D. K., Till, C., Goodman, P. J., Chen, X., Leach, R. J., Johnson-Pais, T. L., Hsing, A. W., Hoque, A., Tangen, C. M., Chu, L., Parnes, H. L., Schenk, J. M., Reichardt, J. K. V., Thompson, I. M. & Figg, W. D., May 1 2015, In : PloS one. 10, 5, e0126672.

Research output: Contribution to journalArticle

19 Scopus citations

Identification of circadian gene variants in bipolar disorder in Latino populations

Gonzalez, R., Gonzalez, S., Villa, E., Ramirez, M., Zavala, J., Armas, R., Contreras, J., Dassori, A. M., Leach, R. J., Flores, D., Jerez, A., Raventós, H., Ontiveros, A., Nicolini, H. & Escamilla, M., Aug 17 2015, In : Journal of Affective Disorders. 186, p. 367-375 9 p.

Research output: Contribution to journalArticle

16 Scopus citations

Improving patient prostate cancer risk assessment: Moving from static, globally-applied to dynamic, practice-specific risk calculators

Strobl, A. N., Vickers, A. J., Van Calster, B., Steyerberg, E., Leach, R. J., Thompson, I. M. & Ankerst, D. P., Aug 1 2015, In : Journal of Biomedical Informatics. 56, p. 87-93 7 p.

Research output: Contribution to journalArticle

13 Scopus citations

Incorporation of detailed family history from the Swedish family cancer database into the PCPT risk calculator

Grill, S., Fallah, M., Leach, R. J., Thompson, I. M., Freedland, S., Hemminki, K. & Ankerst, D. P., Feb 1 2015, In : Journal of Urology. 193, 2, p. 460-465 6 p.

Research output: Contribution to journalArticle

13 Scopus citations

Intermediate-Term Risk of Prostate Cancer is Directly Related to Baseline Prostate Specific Antigen: Implications for Reducing the Burden of Prostate Specific Antigen Screening

Gelfond, J. A., Choate, K., Ankerst, D. P., Hernandez, J., Leach, R. J. & Thompson, I. M., 2015, (Accepted/In press) In : Journal of Urology.

Research output: Contribution to journalArticle

10 Scopus citations

Model-based and context-specific background correction and differential methylation testing for MBDCap-seq

Liu, Y., Wilson, D., Leach, R. J. & Chen, Y., Dec 16 2015, Proceedings - 2015 IEEE International Conference on Bioinformatics and Biomedicine, BIBM 2015. Institute of Electrical and Electronics Engineers Inc., p. 214-219 6 p. 7359683

Research output: Chapter in Book/Report/Conference proceedingConference contribution

Processing of voided urine for prostate cancer RNA biomarker analysis

Quek, S. I., Wong, O. M., Chen, A., Borges, G. T., Ellis, W. J., Salvanha, D. M., Vêncio, R. Z. N., Weaver, B., Ench, Y. M., Leach, R. J., Thompson, I. M. & Liu, A. Y., Dec 1 2015, In : Prostate. 75, 16, p. 1886-1895 10 p.

Research output: Contribution to journalArticle

7 Scopus citations

Variation in genes involved in the immune response and prostate cancer risk in the placebo arm of the Prostate Cancer Prevention Trial

Winchester, D. A., Till, C., Goodman, P. J., Tangen, C. M., Santella, R. M., Johnson-Pais, T. L., Leach, R. J., Xu, J., Zheng, S. L., Thompson, I. M., Lucia, M. S., Lippmann, S. M., Parnes, H. L., Dluzniewski, P. J., Isaacs, W. B., De Marzo, A. M., Drake, C. G. & Platz, E. A., Sep 1 2015, In : Prostate. 75, 13, p. 1403-1418 16 p.

Research output: Contribution to journalArticle

23 Scopus citations
2014

Androgen receptor CAG repeat length and TMPRSS2:ETS prostate cancer risk: Results from the prostate cancer prevention trial

Figg, W. D., Chau, C. H., Price, D. K., Till, C., Goodman, P. J., Cho, Y., Varella-Garcia, M., Reichardt, J. K. V., Tangen, C. M., Leach, R. J., Van Bokhoven, A., Thompson, I. M. & Lucia, M. S., Jan 1 2014, In : Urology. 84, 1, p. 127-131 5 p.

Research output: Contribution to journalArticle

6 Scopus citations

Focusing PSA testing on detection of high-risk prostate cancers by incorporating patient preferences into decision making

Thompson, I. M., Leach, R. J. & Ankerst, D. P., Sep 10 2014, In : JAMA - Journal of the American Medical Association. 312, 10, p. 995-996 2 p.

Research output: Contribution to journalShort survey

25 Scopus citations

Global signaling effects of a schizophrenia-associated missense mutation in neuregulin 1: An exploratory study using whole genome and novel kinome approaches

Marballi, K. K., McCullumsmith, R. E., Yates, S., Escamilla, M. A., Leach, R. J., Raventos, H. & Walss-Bass, C., May 2014, In : Journal of Neural Transmission. 121, 5, p. 479-490 12 p.

Research output: Contribution to journalArticle

2 Scopus citations

Prostate cancer prevention trial risk calculator 2.0 for the prediction of low- vs high-grade prostate cancer

Ankerst, D. P., Hoefler, J., Bock, S., Goodman, P. J., Vickers, A., Hernandez, J., Sokoll, L. J., Sanda, M. G., Wei, J. T., Leach, R. J. & Thompson, I. M., Jun 2014, In : Urology. 83, 6, p. 1362-1368 7 p.

Research output: Contribution to journalArticle

120 Scopus citations

The diagnostic value of adiponectin multimers in healthy men undergoing screening for prostate cancer

Medina, E. A., Shi, X., Grayson, M. H., Ankerst, D. P., Livi, C. B., Medina, M. V., Thompson, I. M. & Leach, R. J., Feb 2014, In : Cancer Epidemiology Biomarkers and Prevention. 23, 2, p. 309-315 7 p.

Research output: Contribution to journalArticle

9 Scopus citations

Validation of copy number variants associated with prostate cancer risk and prognosis

Blackburn, A., Wilson, D., Gelfond, J., Yao, L., Hernandez, J., Thompson, I. M., Leach, R. J. & Lehman, D. M., Jan 2014, In : Urologic Oncology: Seminars and Original Investigations. 32, 1, p. 44.e15-44.e20

Research output: Contribution to journalArticle

2013

Family-based association of an ANK3 haplotype with bipolar disorder in Latino populations

Gonzalez, S. D., Xu, C., Ramirez, M. E., Zavala, J. M., Armas, R., Contreras, S. A., Contreras, J., Dassori, A., Leach, R. J., Flores, D., Jerez, A., Raventós, H., Ontiveros, A., Nicolini, H. & Escamilla, M., Jun 11 2013, In : Translational psychiatry. 3, e265.

Research output: Contribution to journalLetter

4 Scopus citations

Prostate cancer and prostatic intraepithelial neoplasia: True, true, and unrelated?

Thompson, I. M. & Leach, R., Feb 10 2013, In : Journal of Clinical Oncology. 31, 5, p. 515-516 2 p.

Research output: Contribution to journalEditorial

3 Scopus citations
139 Scopus citations

Suggestive evidence for association between L-type voltage-gated calcium channel (CACNA1C) gene haplotypes and bipolar disorder in Latinos: A family-based association study

Gonzalez, S., Xu, C., Ramirez, M., Zavala, J., Armas, R., Contreras, S. A., Contreras, J., Dassori, A., Leach, R. J., Flores, D., Jerez, A., Raventós, H., Ontiveros, A., Nicolini, H. & Escamilla, M., Mar 1 2013, In : Bipolar disorders. 15, 2, p. 206-214 9 p.

Research output: Contribution to journalArticle

18 Scopus citations
2012

Analysis of serum total and free PSA using immunoaffinity depletion coupled to SRM: Correlation with clinical immunoassay tests

Liu, T., Hossain, M., Schepmoes, A. A., Fillmore, T. L., Sokoll, L. J., Kronewitter, S. R., Izmirlian, G., Shi, T., Qian, W. J., Leach, R. J., Thompson, I. M., Chan, D. W., Smith, R. D., Kagan, J., Srivastava, S., Rodland, K. D. & Camp, D. G., Aug 3 2012, In : Journal of Proteomics. 75, 15, p. 4747-4757 11 p.

Research output: Contribution to journalArticle

39 Scopus citations

Genomic characterization of testis cancer: Association of alterations with outcome of clinical stage 1 mixed germ cell nonseminomatous germ cell tumor of the testis

Mohamed, G. H., Gelfond, J. A. L., Nicolas, M. M., Brand, T. C., Sarvis, J. A., Leach, R. J. & Johnson-Pais, T. L., Aug 2012, In : Urology. 80, 2, p. 485.e1-485.e5

Research output: Contribution to journalArticle

6 Scopus citations

Temporal changes in the clinical approach to diagnosing prostate cancer

Hilton, W. M., Padalecki, S. S., Ankerst, D. P., Leach, R. J. & Thompson, I. M., Sep 2012, In : Journal of the National Cancer Institute - Monographs. 45, p. 162-168 7 p.

Research output: Contribution to journalArticle

2 Scopus citations