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  • Thomas F Patterson
2015

Identification of a new class of antifungals targeting the synthesis of fungal sphingolipids

Mor, V., Rella, A., Farnou, A. M., Singh, A., Munshi, M., Bryan, A., Naseem, S., Konopka, J. B., Ojima, I., Bullesbach, E., Ashbaugh, A., Linke, M. J., Cushion, M., Collins, M., Ananthula, H. K., Sallans, L., Desai, P. B., Wiederhold, N. P., Fothergill, A. W., Kirkpatrick, W. R. & 15 others, Patterson, T., Wong, L. H., Sinha, S., Giaever, G., Nislow, C., Flaherty, P., Pan, X., Cesar, G. V., Tavares, P. D. M., Frases, S., Miranda, K., Rodrigues, M. L., Luberto, C., Nimrichter, L. & Poeta, M. D., Jun 23 2015, In : mBio. 6, 3, e00647-15.

Research output: Contribution to journalArticle

51 Scopus citations

Phaeohyphomycosis in transplant recipients: Results from the Transplant Associated Infection Surveillance Network (TRANSNET)

McCarty, T. P., Baddley, J. W., Walsh, T. J., Alexander, B. D., Kontoyiannis, D. P., Perl, T. M., Walker, R., Patterson, T. F., Schuster, M. G., Lyon, G. M., Wingard, J. R., Andes, D. R., Park, B. J., Brandt, M. E. & Pappas, P. G., 2015, In : Medical mycology. 53, 5, p. 440-446 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

The investigational agent E1210 is effective in treatment of experimental invasive candidiasis caused by resistant candida albicans

Wiederhold, N. P., Najvar, L. K., Fothergill, A. W., McCarthy, D. I., Bocanegra, R., Olivo, M., Kirkpatrick, W. R., Everson, M. P., Duncanson, F. P. & Pattersona, T. F., Jan 1 2015, In : Antimicrobial agents and chemotherapy. 59, 1, p. 690-692 3 p.

Research output: Contribution to journalArticle

32 Scopus citations

The novel arylamidine T-2307 maintains in vitro and in vivo activity against echinocandin-resistant Candida albicans

Wiederhold, N. P., Najvar, L. K., Fothergill, A. W., Bocanegra, R., Olivo, M., McCarthy, D. I., Kirkpatrick, W. R., Fukuda, Y., Mitsuyama, J. & Pattersona, T. F., Feb 1 2015, In : Antimicrobial agents and chemotherapy. 59, 2, p. 1341-1343 3 p.

Research output: Contribution to journalArticle

17 Scopus citations

VT-1161 protects immunosuppressed mice from Rhizopus arrhizus var. arrhizus infection

Gebremariam, T., Wiederhold, N. P., Fothergill, A. W., Garvey, E. P., Hoekstra, W. J., Schotzinger, R. J., Patterson, T. F., Filler, S. G. & Ibrahim, A. S., Dec 1 2015, In : Antimicrobial agents and chemotherapy. 59, 12, p. 7815-7817 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

What's new in antifungals: An update on the in-vitro activity and in-vivo efficacy of new and investigational antifungal agents

Wiederhold, N. P. & Patterso, T. F., Nov 3 2015, In : Current Opinion in Infectious Diseases. 28, 6, p. 539-546 8 p.

Research output: Contribution to journalReview article

14 Scopus citations
2014

Antifungal drugs: Mechanisms of action, drug resistance, susceptibility testing, and assays of activity in biologic fluids

Thompson, G. R. & Patterson, T. F., Aug 8 2014, Antibiotics in Laboratory Medicine. Wolters Kluwer Health Adis (ESP)

Research output: Chapter in Book/Report/Conference proceedingChapter

A reference laboratory experience of clinically achievable voriconazole, posaconazole, and itraconazole concentrations withinthe bloodstream and cerebral spinal fluid

Wiederhold, N. P., Pennick, G. J., Dorsey, S. A., Furmaga, W., Lewis, J. S., Patterson, T. F., Sutton, D. A. & Fothergill, A. W., Jan 2014, In : Antimicrobial agents and chemotherapy. 58, 1, p. 424-431 8 p.

Research output: Contribution to journalArticle

39 Scopus citations

Aspergillus Species

Patterson, T. F., Aug 28 2014, Mandell, Douglas, and Bennett's Principles and Practice of Infectious Diseases. Elsevier Inc., Vol. 2. p. 2895-2908 14 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

6 Scopus citations
9 Scopus citations

Endemic fungal infections in solid organ and hematopoietic cell transplant recipients enrolled in the Transplant-Associated Infection Surveillance Network (TRANSNET)

Kauffman, C. A., Freifeld, A. G., Andes, D. R., Baddley, J. W., Herwaldt, L., Walker, R. C., Alexander, B. D., Anaissie, E. J., Benedict, K., Ito, J. I., Knapp, K. M., Lyon, G. M., Marr, K. A., Morrison, V. A., Park, B. J., Patterson, T. F., Schuster, M. G., Chiller, T. M. & Pappas, P. G., Apr 2014, In : Transplant Infectious Disease. 16, 2, p. 213-224 12 p.

Research output: Contribution to journalArticle

68 Scopus citations

Evaluation of an early step-down strategy from intravenous anidulafungin to oral azole therapy for the treatment of candidemia and other forms of invasive candidiasis: Results from an open-label trial

Vazquez, J., Reboli, A. C., Pappas, P. G., Patterson, T. F., Reinhardt, J., Chin-Hong, P., Tobin, E., Kett, D. H., Biswas, P. & Swanson, R., Feb 21 2014, In : BMC Infectious Diseases. 14, 1, 97.

Research output: Contribution to journalArticle

57 Scopus citations

Our 2014 approach to breakthrough invasive fungal infections

Maschmeyer, G. & Patterson, T. F., Nov 1 2014, In : Mycoses. 57, 11, p. 645-651 7 p.

Research output: Contribution to journalArticle

16 Scopus citations
2013

Animal models in mycology: What have we learned over the past 30 years

Kirkpatrick, W. R., Wiederhold, N. P., Najvar, L. K. & Patterson, T. F., Jan 1 2013, In : Current Fungal Infection Reports. 7, 1, p. 68-78 11 p.

Research output: Contribution to journalArticle

6 Scopus citations

Antifungal therapy and length of hospitalization in transplant patients with invasive aspergillosis

Baddley, J. W., Andes, D. R., Marr, K. A., Kauffman, C. A., Kontoyiannis, D. P., Ito, J. I., Schuster, M. G., Brizendine, K. D., Patterson, T. F., Lyon, G. M., Boeckh, M., Oster, R. A., Chiller, T. & Pappas, P. G., Feb 2013, In : Medical mycology. 51, 2, p. 128-135 8 p.

Research output: Contribution to journalArticle

20 Scopus citations

Daptomycin-induced acute eosinophilic pneumonia: Analysis of the current data and illustrative case reports

Phillips, J., Cardile, A. P., Patterson, T. F. & Lewis, J. S., Oct 1 2013, In : Scandinavian Journal of Infectious Diseases. 45, 10, p. 804-808 5 p.

Research output: Contribution to journalArticle

18 Scopus citations

Development and evaluation of a calibrator material for nucleic acid-based assays for diagnosing Aspergillosis

Lyon, G. M., Abdul-Ali, D., Loeffler, J., White, P. L., Wickes, B., Herrera, M. L., Alexander, B. D., Baden, L. R., Clancy, C., Denning, D., Nguyen, M. H., Sugrue, M., Wheat, L. J., Wingard, J. R., Donnelly, J. P., Barnes, R., Patterson, T. F. & Caliendo, A. M., Jul 2013, In : Journal of clinical microbiology. 51, 7, p. 2403-2405 3 p.

Research output: Contribution to journalArticle

19 Scopus citations

Efficacy of liposomal amphotericin B and posaconazole in intratracheal models of murine mucormycosis

Luo, G., Gebremariam, T., Lee, H., French, S. W., Wiederhold, N. P., Patterson, T. F., Filler, S. G. & Ibrahim, A. S., Jul 2013, In : Antimicrobial agents and chemotherapy. 57, 7, p. 3340-3347 8 p.

Research output: Contribution to journalArticle

33 Scopus citations

Fungal infections associated with contaminated methylprednisolone injections

Kauffman, C. A., Pappas, P. G. & Patterson, T. F., Jan 1 2013, In : New England Journal of Medicine. 368, 26, p. 2495-2500 6 p.

Research output: Contribution to journalReview article

69 Scopus citations

Fungal outbreak update from IDWeek

Slama, T., Kauffman, C. A., Patterson, T. F. & Neill, M. A., Feb 18 2013, In : Clinical Infectious Diseases. 56, 5, p. 621-624 4 p.

Research output: Contribution to journalArticle

2 Scopus citations

Interlaboratory and interstudy reproducibility of a novel lateral- Flow device and influence of antifungal therapy on detection of invasive pulmonary aspergillosis

Wiederhold, N. P., Najvar, L. K., Bocanegra, R., Kirkpatrick, W. R., Patterson, T. F. & Thornton, C. R., Feb 1 2013, In : Journal of clinical microbiology. 51, 2, p. 459-465 7 p.

Research output: Contribution to journalArticle

42 Scopus citations

Limited activity of miltefosine in murine models of cryptococcal meningoencephalitis and disseminated cryptococcosis

Wiederhold, N. P., Najvar, L. K., Bocanegra, R., Kirkpatrick, W. R., Sorrell, T. C. & Pattersona, T. F., Feb 1 2013, In : Antimicrobial agents and chemotherapy. 57, 2, p. 745-750 6 p.

Research output: Contribution to journalArticle

22 Scopus citations

Microbiology and epidemiology of oral yeast colonization in hemopoietic progenitor cell transplant recipients

Westbrook, S. D., Kirkpatrick, W. R., Wiederhold, N. P., Freytes, C. O., Toro, J. J., Patterson, T. F. & Redding, S. W., Mar 2013, In : Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology. 115, 3, p. 354-358 5 p.

Research output: Contribution to journalArticle

11 Scopus citations

Prolyl endopeptidase activity in bronchoalveolar lavage fluid: A novel diagnostic biomarker in a guinea pig model of invasive pulmonary aspergillosis

Jambunathan, K., Watson, D. S., Najvar, L. K., Wiederhold, N. P., Kirkpatrick, W. R., Patterson, T. F., Askew, D. S., Kodukula, K. & Galande, A. K., Aug 2013, In : Medical mycology. 51, 6, p. 592-602 11 p.

Research output: Contribution to journalArticle

4 Scopus citations

Rapid emergence of echinocandin resistance in Candida glabrata resulting in clinical and microbiologic failure

Lewis, J. S., Wiederhold, N. P., Wickes, B. L., Patterson, T. F. & Jorgensen, J. H., Sep 2013, In : Antimicrobial agents and chemotherapy. 57, 9, p. 4559-4561 3 p.

Research output: Contribution to journalArticle

60 Scopus citations

Real-world experience in the midst of an Exserohilum meningitis outbreak

Thompson, G. R., Kontoyiannis, D. P. & Patterson, T. F., Jun 24 2013, In : JAMA - Journal of the American Medical Association. 309, 23, p. 2493-2495 3 p.

Research output: Contribution to journalEditorial

2 Scopus citations
2012

Agents of Hyalohyphomycosis and Phaeohyphomycosis

Patterson, T. F. & Sutton, D. A., Aug 30 2012, Principles and Practice of Pediatric Infectious Diseases: Fourth Edition. Elsevier Inc., p. 1209-1212.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

2 Scopus citations

Agents of Mucormycosis (Zygomycosis)

Patterson, T. F. & Sutton, D. A., Aug 30 2012, Principles and Practice of Pediatric Infectious Diseases: Fourth Edition. Elsevier Inc., p. 1212-1215.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

A murine model of Cryptococcus gattii meningoencephalitis

Thompson, G. R., Wiederhold, N. P., Najvar, L. K., Bocanegra, R., Kirkpatrick, W. R., Graybill, J. R. & Patterson, T. F., Jun 2012, In : Journal of Antimicrobial Chemotherapy. 67, 6, p. 1432-1438 7 p., dks060.

Research output: Contribution to journalArticle

20 Scopus citations

Antifungal treatment affects the laboratory diagnosis of invasive aspergillosis

McCulloch, E., Ramage, G., Rajendran, R., Lappin, D. F., Jones, B., Warn, P., Shrief, R., Kirkpatrick, W. R., Patterson, T. F. & Williams, C., Jan 2012, In : Journal of Clinical Pathology. 65, 1, p. 83-86 4 p.

Research output: Contribution to journalArticle

36 Scopus citations

Assessment of aspergillus fumigatus in guinea pig bronchoalveolar lavages and pulmonary tissue by culture and realtime polymerase chain reaction studies

Hooper, D. G., Bolton, V. E., Sutton, J. S., Guilford, F. T., Straus, D. C., Najvar, L. K., Wiederhold, N. P., Kirkpatrick, W. R. & Patterson, T. F., Jan 2012, In : International journal of molecular sciences. 13, 1, p. 726-736 11 p.

Research output: Contribution to journalArticle

1 Scopus citations

Comparison of anidulafungin's and fluconazole's in vivo activity in neutropenic and non-neutropenic models of invasive candidiasis

Wiederhold, N. P., Najvar, L. K., Bocanegra, R., Kirkpatrick, W. R. & Patterson, T. F., Feb 2012, In : Clinical Microbiology and Infection. 18, 2, p. E20-E23

Research output: Contribution to journalArticle

12 Scopus citations

Cryptococcus Species

Thompson, G. R. & Patterson, T. F., Aug 30 2012, Principles and Practice of Pediatric Infectious Diseases: Fourth Edition. Elsevier Inc., p. 1220-1223.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Detection and measurement of fungal burden in a guinea pig model of invasive pulmonary aspergillosis by novel quantitative nested real-time PCR compared with galactomannan and (1,3)-β-D-glucan detection

Lengerova, M., Kocmanova, I., Racil, Z., Hrncirova, K., Pospisilova, S., Mayer, J., Najvar, L. K., Wiederhold, N. P., Kirkpatrick, W. R. & Patterson, T. F., Mar 1 2012, In : Journal of clinical microbiology. 50, 3, p. 602-608 7 p.

Research output: Contribution to journalArticle

25 Scopus citations

Detection of urinary excreted fungal galactomannan-like antigens for diagnosis of invasive aspergillosis

Dufresne, S. F., Datta, K., Li, X., Dadachova, E., Staab, J. F., Patterson, T. F., Feldmesser, M. & Marr, K. A., Aug 10 2012, In : PloS one. 7, 8, e42736.

Research output: Contribution to journalArticle

30 Scopus citations

Fungal disease of the nose and paranasal sinuses

Thompson, G. R. & Patterson, T. F., Feb 2012, In : Journal of Allergy and Clinical Immunology. 129, 2, p. 321-326 6 p.

Research output: Contribution to journalArticle

63 Scopus citations

Malassezia Species

Sutton, D. A. & Patterson, T. F., Aug 30 2012, Principles and Practice of Pediatric Infectious Diseases: Fourth Edition. Elsevier Inc., p. 1215-1218.e2

Research output: Chapter in Book/Report/Conference proceedingChapter

Prophylactic efficacy of single dose pulmonary administration of amphotericin B inhalation powder in a guinea pig model of invasive pulmonary aspergillosis

Kirkpatrick, W. R., Najvar, L. K., Vallor, A. C., Wiederhold, N. P., Bocanegra, R., Pfeiffer, J., Perkins, K., Kugler, A. R., Sweeney, T. D. & Patterson, T. F., Apr 1 2012, In : Journal of Antimicrobial Chemotherapy. 67, 4, p. 970-976 7 p., dkr567.

Research output: Contribution to journalArticle

14 Scopus citations

Sporothrix schenckii (Sporotrichosis)

Patterson, T. F. & Sutton, D. A., Aug 30 2012, Principles and Practice of Pediatric Infectious Diseases: Fourth Edition. Elsevier Inc., p. 1218-1220.e1

Research output: Chapter in Book/Report/Conference proceedingChapter

The changing epidemiology of oropharyngeal candidiasis in patients with HIV/AIDS in the era of antiretroviral therapy

Patel, P. K., Erlandsen, J. E., Kirkpatrick, W. R., Berg, D. K., Westbrook, S. D., Louden, C., Cornell, J. E., Thompson, G. R., Vallor, A. C., Wickes, B. L., Wiederhold, N. P., Redding, S. W. & Patterson, T. F., 2012, In : AIDS Research and Treatment. 2012, 262471.

Research output: Contribution to journalArticle

41 Scopus citations
2011

Aspergillosis

Patterson, T. F., Jan 1 2011, Essentials of Clinical Mycology: Second Edition. Springer New York, p. 243-263 21 p.

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Caspofungin dose escalation for invasive candidiasis due to resistant Candida albicans

Wiederhold, N. P., Najvar, L. K., Bocanegra, R. A., Kirkpatrick, W. R. & Patterson, T. F., Jul 2011, In : Antimicrobial agents and chemotherapy. 55, 7, p. 3254-3260 7 p.

Research output: Contribution to journalArticle

42 Scopus citations
10 Scopus citations

Early treatment of candidemia in adults: A review

Ostrosky-Zeichner, L., Kullberg, B. J., Bow, E. J., Hadley, S., Len, C., Nucci, M., Patterson, T. F. & Perfect, J. R., Feb 1 2011, In : Medical mycology. 49, 2, p. 113-120 8 p.

Research output: Contribution to journalReview article

51 Scopus citations

Human p38 mitogen-activated protein kinase inhibitor drugs inhibit Plasmodium falciparum replication

Brumlik, M. J., Nkhoma, S., Kious, M. J., Thompson, G. R., Patterson, T. F., Siekierka, J. J., Anderson, T. J. C. & Curiel, T. J., Jun 2011, In : Experimental Parasitology. 128, 2, p. 170-175 6 p.

Research output: Contribution to journalArticle

19 Scopus citations

Invasive non-Aspergillus mold infections in transplant recipients, United States, 2001-2006

Park, B. J., Pappas, P. G., Wannemuehler, K. A., Alexander, B. D., Anaissie, E. J., Andes, D. R., Baddley, J. W., Brown, J. M., Brumble, L. M., Freifeld, A. G., Hadley, S., Herwaldt, L., Ito, J. I., Kauffman, C. A., Lyon, G. M., Marr, K. A., Morrison, V. A., Papanicolaou, G., Patterson, T. F., Perl, T. M. & 5 others, Schuster, M. G., Walker, R., Wingard, J. R., Walsh, T. J. & Kontoyiannis, D. P., Oct 2011, In : Emerging Infectious Diseases. 17, 10, p. 1855-1864 10 p.

Research output: Contribution to journalArticle

156 Scopus citations

Pulmonary aspergillosis: Recent advances

Thompson, G. R. & Patterson, T. F., Dec 21 2011, In : Seminars in Respiratory and Critical Care Medicine. 32, 6, p. 673-681 9 p.

Research output: Contribution to journalArticle

25 Scopus citations

Reply to Dr Yong

Thompson, G. R. & Patterson, T. F., Apr 1 2011, In : Medical mycology. 49, 3, 1 p.

Research output: Contribution to journalLetter